Local Tolerability of AN2728 Topical Ointment, 2% in ... - Anacor
Local Tolerability of AN2728 Topical Ointment, 2% in ... - Anacor
Local Tolerability of AN2728 Topical Ointment, 2% in ... - Anacor
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Grad<strong>in</strong>g <strong>of</strong> <strong>Local</strong> <strong>Tolerability</strong> Symptoms<br />
Grade Burn<strong>in</strong>g / St<strong>in</strong>g<strong>in</strong>g Pruritus Erythema<br />
0<br />
(None)<br />
1<br />
(Mild)<br />
2<br />
(Moderate)<br />
3<br />
(Severe)<br />
No st<strong>in</strong>g<strong>in</strong>g / burn<strong>in</strong>g<br />
Slight warm, t<strong>in</strong>gl<strong>in</strong>g<br />
sensation; not really<br />
bothersome<br />
Def<strong>in</strong>ite warm, t<strong>in</strong>gl<strong>in</strong>g<br />
sensation that is<br />
somewhat bothersome<br />
Hot, t<strong>in</strong>gl<strong>in</strong>g / st<strong>in</strong>g<strong>in</strong>g<br />
sensation that has caused<br />
def<strong>in</strong>ite discomfort<br />
No pruritus<br />
Occasional, slight itch<strong>in</strong>g /<br />
scratch<strong>in</strong>g<br />
Constant or <strong>in</strong>termittent<br />
itch<strong>in</strong>g / scratch<strong>in</strong>g which<br />
is not disturb<strong>in</strong>g sleep<br />
Bothersome itch<strong>in</strong>g /<br />
scratch<strong>in</strong>g which is<br />
disturb<strong>in</strong>g sleep<br />
No detectable<br />
erythema, sk<strong>in</strong> <strong>of</strong><br />
normal color<br />
Slight p<strong>in</strong>kness<br />
present<br />
Def<strong>in</strong>ite redness,<br />
easily recognized<br />
Intense redness<br />
Note: Grades <strong>of</strong> 0.5, 1.5, & 2.5 were allowed as midpo<strong>in</strong>ts between the def<strong>in</strong>ite grades <strong>of</strong><br />
0, 1, 2 & 3.<br />
5
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