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Local Tolerability of AN2728 Topical Ointment, 2% in ... - Anacor

Local Tolerability of AN2728 Topical Ointment, 2% in ... - Anacor

Local Tolerability of AN2728 Topical Ointment, 2% in ... - Anacor

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Psoriasis: Plaque-type and Inverse Patterns<br />

Psoriasis vulgaris or plaque-type psoriasis, the most common form<br />

<strong>of</strong> psoriasis, is characterized by thick plaques primarily on the<br />

elbows, knees, umbilicus, genital area, lower back, and scalp<br />

A significant m<strong>in</strong>ority <strong>of</strong> psoriasis patients have an <strong>in</strong>verse pattern <strong>of</strong><br />

psoriasis, <strong>in</strong>volv<strong>in</strong>g the sk<strong>in</strong> folds, recesses, genitalia, and other<br />

th<strong>in</strong>-sk<strong>in</strong>ned areas generally considered to be more easily irritated<br />

The use <strong>of</strong> many exist<strong>in</strong>g topical psoriasis treatments are commonly<br />

avoided <strong>in</strong> sensitive or <strong>in</strong>tertrig<strong>in</strong>ous areas due to the <strong>in</strong>creased<br />

potential for both topical and systemic side effects<br />

This study was conducted to exam<strong>in</strong>e the local tolerability <strong>of</strong><br />

<strong>AN2728</strong> <strong>Topical</strong> <strong>O<strong>in</strong>tment</strong>, <strong>2%</strong> compared to vehicle <strong>in</strong> sensitive sk<strong>in</strong><br />

areas <strong>of</strong> healthy volunteers<br />

3

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