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ORBIT/ PLASTIC SURGERY SESSION-II<br />

413<br />

ORBIT / PLASTIC SURGERY SESSION-II<br />

Chairman: Dr. Ashok Kumar Grover, Co-Chairman: Dr. S.C. Das<br />

Convenor: Dr. Usha Singh, Moderator: Dr. Swarup Pathak<br />

AUTHORS’S PROFILE:<br />

DR. DEBRAJ SHOME, M.B.B.S. (2000), Grant Medical College, Mumbai University; D.O.<br />

(2003), Sankara Nethralaya, Chennai; D.N.B. (2004); FRCS (2003) (Glasgow); M.R.C.S. (Part-I)<br />

(2003) (Edinburgh); ICO Basic Sciences Assessment (2002), Fellowship in Ophthalmic Plastic<br />

Surgery, Orbit and Ocular Oncology, L.V. Prasad Eye Institute, Hyderabad. Formerly,<br />

Consultant Ophthalmic Surgeon at Rotary Eye Hospital, Navasari, Gujrat. Recipient of Best FP<br />

Award in Orbit and Inflamation Session, AIOC-2006, Bhopal. Presently Consultant, Orbit and<br />

Ocular Oncology, Aditya Jyot Eye Hospital Pvt. Ltd., Wadala, Mumbai.<br />

Implant and Prosthetic Motility – Is There Really A Difference<br />

between Expensive Porous Polyethylene Implants and The Humble<br />

Inexpensive Silicone Implant — A Randomized Controlled Trial<br />

Dr. Debraj Shome, Dr. Kuldeep Raizada, Dr. Deepa Rani, Dr. Santosh G Honavar<br />

(Presenting Author: Dr. Debraj Shome)<br />

Enucleation of the eye is often considered a<br />

failure for an ophthalmologist and the end of<br />

a professional relationship. On the contrary, it is<br />

the beginning of a new relationship aimed at<br />

providing optimal cosmesis and maintaining a<br />

healthy socket. For a patient who has already lost<br />

vision in his eye, good cosmesis can often be<br />

equated with greater self-esteem.<br />

Motility of implants and subsequently movement<br />

of the overlying prosthesis is an important aspect<br />

of cosmesis. Implants used can be integrable or<br />

non-integrable with <strong>orbit</strong>al tissues.<br />

Non integrated implants are inexpensive,<br />

technically uncomplicated, well tolerated, and<br />

have very few complications. However, nonintegrated<br />

implants do not allow direct or<br />

indirect integration with the <strong>orbit</strong>al structures or<br />

with the prosthesis. Such implants have no direct<br />

attachment to the prosthesis. Although various<br />

materials have been used to make nonintegrated<br />

implants in the past, the current favourite is<br />

silicone. Silicone is less prone to migration<br />

because a layer of fibrous tissue sequestrates it.<br />

In contradistinction, integrable implant materials<br />

like porous polyethylene get bio-integrated to the<br />

<strong>orbit</strong>al soft tissues and are reported to provide<br />

better implant and prosthetic motility. The 400-<br />

micron large pore size of this material allows<br />

fibrovascular ingrowth and causes integration.<br />

However, these implants are very expensive and<br />

can get exposed because of the presence of an<br />

outer rough surface.<br />

Enucleation, at present, consists of three main<br />

techniques; all done with a view of improving<br />

implant motility and subsequent prosthetic<br />

motility.<br />

These are:<br />

1. Enucleation by the traditional ‘muscle to<br />

muscle imbrication’ technique<br />

2. Enucleation by the myoconjunctival<br />

technique<br />

3. Enucleation with the use of integrable porous<br />

polyethylene or hydroxyapatite implants.<br />

The present study attempts to compare the<br />

differences in implant and prosthetic motility<br />

amongst all these three techniques.<br />

To Evaluate implant and prosthesis motility via<br />

three techniques: Post silicone implant insertion<br />

with muscle imbrication (the traditional age-old<br />

technique of enucleation), post silicone implant<br />

insertion by myoconjunctival technique (MT)<br />

(the extra-ocular muscles are sutured to the<br />

fornices insted of to each other) & post porous<br />

polyethylene implantation via the scleral cap<br />

technique.<br />

Study Design<br />

Randomised Controlled Double-Blind,<br />

Prospective, Interventional Study.


414 AIOC 2009 PROCEEDINGS<br />

Materials and Methods<br />

75 patients per group were included in this multicentric<br />

trial. Patients were randomized using<br />

stratified randomisation. <strong>All</strong> patients were<br />

operated by two experienced surgeons.<br />

Implant and prosthesis motility were the primary<br />

outcome measures.<br />

Custom-made acrylic prostheses by a trained<br />

ocularist were fitted six weeks post <strong>surgery</strong> in all<br />

patients. A masked observer measured implant<br />

and prosthesis motility using a custom-made slitlamp<br />

device with real-time video and still<br />

photographic documentation. The measurement<br />

was repeated by a second masked observer on<br />

the computer using the photos of movements in<br />

all gazes captured and an average of the<br />

measurements of the first and the second<br />

observers were taken. If the difference in<br />

measurements between the two observers was<br />

greater than 2 Standard Deviations, the<br />

measurements were repeated.<br />

Surgical Technique<br />

Until the eyeball is enucleated, all the steps are<br />

similar in all three techniques.<br />

An <strong>orbit</strong>al implant is placed either posterior to<br />

the posterior Tenon’s (nonintegrated implants) or<br />

within the Tenon’s capsule (integrated implants).<br />

There are two options to deal with the<br />

extraocular muscles if a nonintegrated implant is<br />

placed – one is to imbricate the lateral rectus to<br />

the medial rectus and the superior rectus to the<br />

inferior rectus; over the posterior tenons.<br />

The other is the myoconjunctival technique<br />

where each of the recti is attached to the posterior<br />

aspect of conjunctiva-Tenons close to the<br />

respective fornix. The muscles are then passed<br />

thru the anterior Tenon’s and the conjunctival<br />

layer and then sutured to the respective fornices.<br />

This technique of muscle suturing is supposed to<br />

impart greater implant motility as well as deeper<br />

fornices, post <strong>surgery</strong>. Thus, myoconjunctival<br />

technique may provide better prosthesis mobility<br />

and reduce the risk of implant displacement (the<br />

“sling effect” of the imbricated recti is one of the<br />

causes of implant displacement).<br />

Porous polyethylene implants are implanted via<br />

the ‘scleral cap’ technique. A scleral disc is cut out<br />

from donor sclera and is sutured to the implant<br />

with 6-0 vicryl sutures. The implant is inserted<br />

via an inserter, which is included with the<br />

implant. This implant is placed anterior to the<br />

posterior tenon layer. The muscles are then<br />

sutured to the disc with the 6-0 vicryl sutures.<br />

The muscles can be attached to integrated<br />

implants either directly (porus polyethylene or<br />

coated hydroxyapatite implants) or to the<br />

wrapping material. Exaggerated anterior<br />

attachment of the muscles within 5 mm of the<br />

implant's central axis is currently advocated. This<br />

is believed to result in more posteriorly<br />

positioned implant, reducing the risk of<br />

exposure.<br />

The subsequent steps of closure and conformer<br />

insertion are similar in all three techniques.<br />

Measurement device and technique<br />

An independent observer measured motility<br />

using a custom-made slit-lamp device with realtime<br />

video documentation. The measurement<br />

device was indigenously made in-house at our<br />

institute.<br />

The device has two millimeter rulers, having the<br />

dimension of 15mm and 5mm respectively. The<br />

larger ruler represented the X axis while the<br />

smaller one represented the Y axis. The larger<br />

horizontal ruler was fixed from the Center while<br />

the vertical one was arranged such that it could<br />

be moved along the X axis. The complete<br />

measurement device was mounted on a rod of<br />

length 15 mm and with the overall diameter of<br />

6mm, which was then attached to the Slit lamp<br />

biomicroscope in the Hruby lens holder. This<br />

Hruby Lens holder can be moved in 5mm in each<br />

direction from its center, while the whole<br />

Instrument can be moved in Y axis as per the<br />

individual patient and can also be fixed for the<br />

particular individual.<br />

The implant motility, prosthesis measurement<br />

and prosthetic motility were checked after 6<br />

weeks post-<strong>surgery</strong> in all patients.<br />

Once it was established that the socket was<br />

healthy, then topical anaesthesia was instilled.<br />

Using a non-toxic colour marker (Sharpie ADA<br />

approved), the center of the palpebral fissure was<br />

marked. The patient was made to comfortably sit<br />

on the slit lamp biomicroscope. The external<br />

digital camera was aligned to face the patient.


ORBIT/ PLASTIC SURGERY SESSION-II<br />

415<br />

This camera was kept at a prior marked distance<br />

of 1.5 ft and the zoom was kept at 2.3 x in all<br />

patients for standardization.<br />

Using a wire speculum the visible mark was<br />

viewed and then ductions in all directions were<br />

photographed.<br />

Once the prosthesis was ready, it was placed in<br />

situ in the socket and the center of the pupil of<br />

the prosthesis was marked with an erasable<br />

white marker. The prosthetic movement was<br />

then measured in all directions with<br />

photographs.<br />

The photograph was downloaded onto the<br />

computer and then the measurement was carried<br />

out via Adobe Photoshop version 6.0. This was<br />

done to avoid parallax error which could have<br />

occurred if assessment was done directly with<br />

the patient on the slit lamp.<br />

Fornix depth and implant displacement were<br />

also noted.<br />

Result<br />

In the myoconjunctival group, the mean implant<br />

motility on adduction was 3.67mm,on abduction<br />

4 mm and the total motility was 7.66mm in the<br />

horizontal meridian; the upward motility was<br />

2.82mm, the downward motility was 3.18mm<br />

and the total motility was 6 mm in the vertical<br />

meridian. The prosthetic motility was 4.22mm for<br />

adduction, 3.78 mm for abduction and 8 mm total<br />

in the horizontal meridian and 3.22 mm for<br />

supra-duction, 3.56 mm for infra-duction and<br />

6.77 mm totally in the vertical meridian.<br />

In the traditional enucleation with silicone<br />

implant group, the mean implant motility on<br />

adduction was 3.82 mm, on abduction 1.32 mm<br />

and the total motility was 3.27 mm in the<br />

horizontal meridian and the upward motility<br />

was 1.36 mm, the downward motility was 1.32<br />

mm and the total motility was 3.68 mm in the<br />

vertical meridian. The prosthetic motility was<br />

1.82 mm for adduction, 2.30 mm for abduction<br />

and 3.90 mm total in the horizontal meridian and<br />

1.36 mm for supra-duction, 2 mm for infraduction<br />

and 3.36 mm totally in the vertical<br />

meridian.<br />

In the porous polyethylene group, the mean<br />

implant motility on adduction was 3.50 mm, on<br />

abduction 3.60 mm and the total motility was<br />

7.10 mm in the horizontal meridian and the<br />

upward motility was 2.75 mm, the downward<br />

motility was 2.95 mm and the total motility was<br />

5.80 mm in the vertical meridian. The prosthetic<br />

motility was 3.80 mm for adduction, 3.65 mm for<br />

abduction and 7.45 mm total in the horizontal<br />

meridian and 3 mm for supra-duction, 3.30 mm<br />

for infra-duction and 6.30 mm totally in the<br />

vertical meridian.<br />

Analysis was done by the Mann-Whitney U test.<br />

As the sample size was small, statistical level of<br />

significance was fixed at 10%.<br />

As three groups were present, P value of ≤0.03<br />

was considered significant.<br />

MT silicone implant motility was better than<br />

traditional silicone (P = 0.001) & similar to porous<br />

polyethylene. Even more surprisingly, prosthesis<br />

motility post MT insertion was better than post<br />

both traditional silicone (P = 0.001) & porous<br />

polyethylene (P = 0.002).<br />

Differences in implant motility were not<br />

significant in both meridia between the porex<br />

and the myoconjunctival group.<br />

Thus, Myoconjunctival silicone implant showed<br />

better motility and fornix depth than the<br />

traditional route and the porous polyethylene<br />

group. Only traditional silicone implants tended<br />

to displace.<br />

Discusion<br />

Silicone implant by myoconjunctival technique<br />

provides better implant and prosthesis motility<br />

and may be preferred over expensive porous<br />

polyethylene implant.<br />

To the best of our knowledge, this is the first<br />

study of its kind comparing implant and<br />

prosthesis motility in these groups of enucleation<br />

with implants.<br />

References<br />

1. Moshfeghi DM, Moshfeghi AA, Finger PT.<br />

Enucleation. Surv Ophthalmol 44;4:277-301.<br />

2. Yadava U, Sachdeva P, Arora A. Myoconjunctival<br />

Enucleation for Enhanced Implant Motility. Result<br />

of a Randomised Prospective Study. <strong>India</strong>n J<br />

Ophthalmol 2004;52:221-6.


416 AIOC 2009 PROCEEDINGS<br />

AUTHORS’S PROFILE:<br />

DR. ASHOK KUMAR GROVER: M.B.B.S.(’76), Maulana Azad Medical College, New Delhi;<br />

M.S. (’80), Dr. Rajendra Prasad Centre for Ophthalmic Science, AIIMS, New Delhi. He was on<br />

the faculty of Maulana Azad Medical College as chief of Oculo<strong>plastic</strong> service. Received the<br />

prestigious Col. Rangachari Award, AIOC. President Elect of Oculo<strong>plastic</strong> Association of <strong>India</strong>.<br />

Past president, Federation of Ophthalmic Research and Education Centers (<strong>India</strong>) and Delhi<br />

<strong>Ophthalmological</strong> <strong>Society</strong> (DOS). Presently, Chairman of the Dept. of Ophthalmology at Sir<br />

Ganga Ram Hospital, New Delhi.<br />

Surgical Techniques in The Management of Contracted<br />

Anophthalmic Socket — A Retrospective Study<br />

Dr. Ashok Kumar Grover, Dr. Pracheer R. Agarwal, Dr. Rituraj Baruah,<br />

Dr. Shaloo Bhageja<br />

(Presenting Author: Dr. Ashok Kumar Grover)<br />

Contracted socket at times becomes a major<br />

aesthetic concern for the patient as well as<br />

the treating surgeon leading to multiple<br />

surgeries. A number of proven surgical<br />

techniques are at the disposal of the surgeon but<br />

assessing the condition and the correct<br />

application of the technique to get the optimum<br />

acceptable result is the key to the success.<br />

Successful reconstruction of the contracted socket<br />

requires that a stable fornix with adequate depth<br />

be established by increasing the surface area with<br />

the use of grafts, and if necessary volume<br />

replacement with <strong>orbit</strong>al implants.<br />

Evaluation of different surgical techniques in the<br />

management of contraction of the anophthalmic<br />

socket.<br />

Materials and Methods<br />

This is a retrospective study of 39 patients who<br />

presented with contraction of anophthalmic<br />

socket between February 2003 and October 2007.<br />

Meticulous history was taken to find out the<br />

sequence of events. History or records of<br />

techniques and any other treatment modalities<br />

like radiotherapy etc used were elicited.<br />

The socket contraction was first categorised into<br />

mild (9), moderate (10) and severe (20).<br />

Associated abnormalities like granuloma<br />

formation, partial or complete extrusion of<br />

implant, laxity of lower eyelids, volume<br />

deficiency with sulcus deformity, band formation<br />

etc were looked for.<br />

After carefully assessing the cases, appropriate<br />

treatment modality was decided and executed<br />

accordingly.<br />

Techniques used were prosthesis modification (2<br />

cases), fornix forming suture (7 cases), mucous<br />

membrane graft (23 cases), dermis fat graft (5<br />

cases) and epidermal graft (2 cases). Granuloma<br />

excision was carried out in 3 cases.<br />

Post operatively, all patients were examined to<br />

record whether they were able to retain a<br />

cosmetically acceptable prosthesis and maintain<br />

good function of the <strong>orbit</strong> and eyelids. Patients<br />

were followed for a period varying from 6<br />

months to 4 years.<br />

Results<br />

Of the 39 cases of contracted socket 29 were male<br />

and 10 were female. Age varied from 5 years to<br />

54 years. Thirty of the patients had a satisfactory<br />

surgical outcome so that a well fitting prosthesis<br />

could be fitted. In nine cases either adequate<br />

space could not be created or a recurrence of<br />

contraction supervened. This tended to occur in<br />

the severe group, especially in patients with<br />

previous radiotherapy.<br />

Discussion<br />

As it is already established, mucus membrane<br />

lining the socket often tends to shrink with time.<br />

Bouts of low grade infection, failure to used a<br />

correctly fitted conformer, implant extrusion and<br />

migration, sharp edge of artificial eye , faulty<br />

techniques of enucleation with injudicious<br />

sacrifice of bulbar conjunctiva are the common<br />

causes of contracted socket.<br />

Reconstruction of mild to moderate contraction<br />

can be optimally tackled with mucus membrane<br />

graft. Dermis fat graft is of utmost importance<br />

when increase volume and surface area are


ORBIT/ PLASTIC SURGERY SESSION-II<br />

417<br />

Mild Moderate Severe<br />

Dermis fat graft in case of deep<br />

Shallow inferior<br />

fornix<br />

Cicatricial band<br />

Granulation<br />

tissue<br />

Shallow inferior socket with fornix forming suture<br />

MM Grafting<br />

desired. The dermis enhances the<br />

vascularization, decrease the incidence of fat<br />

atrophy and act as a barrier against fatty<br />

augmentation. Extensive socket contraction can<br />

be dealt with full or partial thickness oral<br />

mucosal graft. However, grafting the palpebral<br />

surface requires rigidity which is absent with<br />

these mucosal graft.<br />

Complete restoration of space for prosthetic eye<br />

can achieved in the milder group with fornix<br />

1. Sihota R, The fat pad in dermis fat grafts.<br />

Ophthalmology 1994;101:231-4.<br />

2. Puterman AM. A surgical technique for the<br />

successful and stable reconstruction of the totally<br />

contracted ocular socket. Ophthalmic surg.<br />

1988;19;193-201.<br />

The established treatment for ptosis with poor<br />

levator function is frontalis sling suspension<br />

<strong>surgery</strong>. The upper ptotic lid is attached to the<br />

frontalis muscle and the lid is elevated actively<br />

on elevating brow. Various different materials<br />

References<br />

Superior sulcus deformity with levator resection<br />

forming suture in 7 of our cases. Dermis fat graft<br />

gave excellent results. However, in the severe<br />

group, 4 cases where adequate space could not<br />

be maintained for a longer period had history of<br />

exposure to radiotherapy.<br />

Surgical techniques like mucous membrane<br />

grafting, epidermal and dermis fat grafting give<br />

satisfactory results in patients of socket<br />

contraction, when done in appropriate cases with<br />

meticulous surgical technique.<br />

3. SM Betheria, Surgical management of contracted<br />

socket. IJO 1988;36/2:79-81.<br />

4. Raizada K. Management of an irradiated<br />

anophthalmic socket following dermis fat graft<br />

rejection: a case report. IJO 2008;56:147-8.<br />

Evaluation of Frontalis Sling Surgery Using Silicone Rod for<br />

Correction of Blepharoptosis in <strong>India</strong>n Population in a Tertiary<br />

Eye Care Centre<br />

Dr. Usha R., Dr. Gagan Dudeja<br />

(Presenting Author: Dr. Gagan Dudeja)<br />

have been used for frontalis suspension such as<br />

non absorbable sutures, sclera, suture reinforced<br />

sclera, autogenous and preserved fascia lata,<br />

temporalis fascia, skin strips, GoreTex strips,<br />

silicone bands and rods.


418 AIOC 2009 PROCEEDINGS<br />

Tillet et al in 1966 first described frontalis<br />

suspension with No. 40 silicone strip used in<br />

retinal detachment <strong>surgery</strong>. Several other<br />

workers have reported use of silicone material in<br />

different physical configuration.<br />

We report our experience with silicone rod (BD -<br />

Visitec frontalis suspension set with silicone rod<br />

and malleable needle) for frontalis Sling<br />

suspension <strong>surgery</strong> for correction of ptosis.<br />

Materials and Methods<br />

65 lids of 56 consecutive patients meeting the<br />

inclusion criteria were enrolled for the study.<br />

The inclusion criteria were severe congenital<br />

ptosis with poor levator function i.e. upper lid<br />

margin and pupillary reflex distance (MRD 1) of<br />

0 to 1 mm and poor levator function < 4mm<br />

(Burke’s method), Third nerve palsy, Chronic<br />

progressive external ophthalmoplegia (CPEO),<br />

Myasthenia gravis (MG), Post traumatic Levator<br />

disinsertion, Myotonic dystrophy and Congenital<br />

ocular fibrosis syndrome.<br />

Exclusion criteria were acquired ptosis e.g.<br />

Horner’s syndrome, Blepharochalasis,<br />

Dermatochalasis, Mechanical ptosis, Mild or<br />

Moderate congenital ptosis (MRD 1 >1)<br />

The <strong>surgery</strong> was performed under local<br />

anaesthesia in adults and general anaesthesia in<br />

children. Frontalis Sling Suspension was<br />

performed using modified Fox pentagon<br />

technique using Visitec silicone rod frontalis<br />

suspension set. Five incision sites for Fox<br />

pentagon were marked. First two marks were<br />

made in upper lid lateral to temporal limbus and<br />

medial to medial limbus 2 mm above lash line.<br />

Next two marks were made just medial and<br />

lateral to lid incision above superior brow hairs.<br />

A forehead incision was then marked midway<br />

about 1 cm above brow. The five incisions were<br />

then made with Elllman RF cautery. A pocket<br />

was dissected beneath frontalis muscle<br />

superiorly for burying the sleeve . The needle of<br />

sling suspension set was then slightly bent and<br />

passed from central forehead incision to lid<br />

incision and back to forehead incision in<br />

clockwise manner to form a pentagon. Lid Guard<br />

was used to protect the cornea and support the<br />

lid. The two Needles were then passed through<br />

the sleeve and the sling was tightened to obtain<br />

required lid height and contour. The silicone rod<br />

was then cut and the sleeve was buried in pocket<br />

made between frontalis muscle. The forehead<br />

incision was then closed with 6’0 Vicryl Suture.<br />

Frost suture was then taken and left in place for<br />

one day. Post operatively lid height, contour,<br />

lagophthalmos and corneal exposure was<br />

assessed in all the patients.<br />

In case of a bilateral frontalis sling <strong>surgery</strong> ideal<br />

upper lid height post operatively is ½ mm below<br />

superior limbus. But in case of an unilateral<br />

<strong>surgery</strong> it needs to be matched with the lid height<br />

of the other eye. Under correction is desirable in<br />

cases having poor Bells phenomenon such as<br />

CPEO, MG and Third nerve palsy. The post<br />

operative correction was graded as good if the lid<br />

height was equal to or 1 mm lower than the<br />

desired correction, fair if it was 1 to 2mm lower<br />

than the desired level and poor if it was more<br />

than 2 mm lower than the desired level.<br />

Intraoperative and postoperative complications<br />

were recorded. The patients were followed up<br />

post operatively for a minimum period of six<br />

months.<br />

Results<br />

The age of patients ranged from 4 months to 55<br />

years. 36 patients were male and 20 patients were<br />

female. The pre operative diagnoses were Simple<br />

severe congenital Ptosis in 32 (57 %) cases,<br />

Blepharophimosis syndrome in 6 (11%) cases,<br />

Synkinetic Ptosis in 11 (20%) cases, third nerve<br />

palsy in 1 (1.8%) case, post traumatic LPS<br />

disinsertion 3 (5.4%) cases Myotonic Dystrophy<br />

in 1(1.8%) case, CPEO in 1 (1.8%) case and<br />

Congenital ocular fibrosis syndrome 1 (1.8%)<br />

case.<br />

Pre operatively 9 patients had poor Bells<br />

phenomenon. Surgical procedure performed was<br />

Frontalis Sling suspension in 38 patients, YV<br />

plasty and Frontalis Sling in 10 patients and<br />

Levator disinsertion and Frontalis Sling in 11<br />

patients.<br />

Postoperative 56 (86.15%) eyes had good<br />

correction. 8 (12.30%) patients had fair correction<br />

and 1 (1.50%) patient had poor correction.<br />

Lagophthalmos was grade 1 in 10 (15.40 %)eyes,<br />

grade 2 in 50 (77 %) eyes and grade 3 in 5 (7.70%)<br />

eyes.<br />

Complications encountered were corneal<br />

exposure in 4 patients 2 of them underwent<br />

loosening of sling and 2 were managed by use of<br />

topical lubricants and taping at night .1 patient


ORBIT/ PLASTIC SURGERY SESSION-II<br />

419<br />

developed pre septal cellulites and was managed<br />

on parenteral antibiotics and removal of sling. 1<br />

Patient had recurrence of Ptosis due to slippage<br />

of silicone rod over tarsus. 1 patient had<br />

granuloma formation, which was managed<br />

conservatively. 3 patients underwent sling<br />

readjustment.<br />

Discussion<br />

Ever since 1966 when Tillet et al reported use of<br />

Silicone band No. 40 for frontalis sling<br />

suspension <strong>surgery</strong> the material has been found<br />

to have excellent biocompatibility. Various<br />

different types of silicone rods and bands along<br />

with different surgical techniques have been used<br />

and reported but all of them in a small number<br />

of patients. There are no published reports for<br />

<strong>India</strong>n population. Our series presents the results<br />

of frontalis sling suspension using silicone rod<br />

material in <strong>India</strong>n population.<br />

1. Tillett CW, Tillett GM. Silicone sling in the<br />

correction of ptosis. Am J ophthalmol. 1966;62(3):521-<br />

3.<br />

2. Leone CR Jr, Rylander G. A modified silicone<br />

frontalis sling for the correction of blepharoptosis.<br />

Am J Ophthalmol 1978;85:802-5.<br />

3. Carter SR, Meecham WJ, Seiff SR. Silicone frontalis<br />

slings for the correction of blepharoptosis:<br />

indications and efficacy. Ophthalmology<br />

1996;103:623-30.<br />

4. Green JP, Wojno T.Removal of an infected silicone<br />

Orbital cellulitis can be classified as preseptal<br />

and post septal cellulitis based on the<br />

anatomic landmark, the <strong>orbit</strong>al septum. The<br />

septum forms a barrier separating the spread of<br />

superficial infection into the deeper <strong>orbit</strong>. Orbital<br />

infection limited anterior to the septum is called<br />

preseptal cellulitis and that posterior to septum<br />

is termed as post-septal cellulitis or <strong>orbit</strong>al<br />

cellulitis. Clinical distinction of the two is<br />

important as the ocular morbidity and prognosis<br />

differs.<br />

Preseptal cellulitis is characterized by lid edema,<br />

References<br />

Silicone Rod as a material has:<br />

1) Excellent Biocompatibility that is well tolerated<br />

by body tissues, 2) It has good elasticity, which<br />

provides for good lid closure. 3) It can be easily<br />

adjusted because of use of sleeve.<br />

Severe unilateral or bilateral congenital ptosis<br />

may result in abnormal head posture and<br />

amblyopia due to occlusion of visual axis.<br />

Therefore surgical intervention is indicated at an<br />

early age. Fascia lata cannot be harvested in<br />

children below three years of age, which<br />

mandates the use of non-autogenous material<br />

like Silicone Rod. The ptosis may be of variable<br />

progression in some conditions such as CPEO,<br />

MG and Myopathy and it may increase with<br />

worsening of myopathy or may improve as in<br />

cases of myasthenia gravis. <strong>All</strong> these conditions<br />

may need sling adjustment, which is easily done<br />

in case of a silicone sling <strong>surgery</strong>.<br />

rod frontalis sling without recurrence of ptosis.<br />

Ophthal Plast Reconstr Surg. 1997;13:285-6.<br />

5. Bernardini FP, de Concil<strong>ii</strong>s C, Devoto MH. Frontalis<br />

suspension sling using a silicone rod in patients<br />

affected by myogenic blepharoptosis. Orbit<br />

2002;21:195-8.<br />

6. Ben Simon GJ, Macedo AA, Schwarcz RM, Wang<br />

DY, McCann JD, Goldberg RA. Frontalis suspension<br />

for upper eyelid ptosis: evaluation of different<br />

surgical designs and suture material. Am J<br />

Ophthalmol. 2005;140:877-85.<br />

Nine Years Review on Preseptal and Orbital Cellulitis in A<br />

Tertiary Care Hospital in South <strong>India</strong><br />

Dr. Datta Gulnar Pandian, Dr. Ramesh Babu K, Dr. Chaitra S., Dr. Anjali A<br />

(Presenting Author: Dr. Datta Gulnar Pandian)<br />

warmth, erythema and tenderness. Distinctive<br />

features of <strong>orbit</strong>al cellulitis are proptosis and<br />

limitation of ocular movements. 1 Additional<br />

useful signs are chemosis of bulbar conjunctiva,<br />

reduced visual acuity, afferent pupillary defect<br />

and toxic systemic symptoms. Prompt diagnosis<br />

and treatment of <strong>orbit</strong>al cellulitis is vital as it is<br />

associated with serious complications like<br />

cavernous venous thrombosis, visual loss,<br />

meningitis and sepsis. 1,2<br />

In this study we reviewed the in-patient records<br />

of patients with pre- and post-septal cellulitis


420 AIOC 2009 PROCEEDINGS<br />

over nine years in a tertiary care hospital. The<br />

clinical findings, causative organism,<br />

management and complications of the two<br />

conditions are illustrated.<br />

Materials and Methods<br />

The in-patient records of patients with preseptal<br />

and <strong>orbit</strong>al cellulitis were reviewed from 1998 to<br />

2006. The clinical details of the patients were<br />

noted and analysed. Patients were classified as<br />

having preseptal or <strong>orbit</strong>al cellulitis.<br />

The factors reviewed in the study included ocular<br />

findings aiding in the distinction of the two<br />

clinical conditions, the duration of symptoms at<br />

the time of presentation, the duration of hospital<br />

stay, microbiological culture report of pus or<br />

wound swab, blood culture, drugs used for<br />

treatment, response to therapy and<br />

complications. Other parameters studied were<br />

general physical examination, systemic blood<br />

counts and temperature. Wound swab was taken<br />

either from the site of infection or ulceration or<br />

conjunctival sac. This was immediately sent for<br />

culture and sensitivity. Pus was examined by<br />

Gram's staining, KOH mount and cultured on<br />

blood agar, chocolate agar and Sabourauds<br />

dextrose agar. Radiological investigations like x-<br />

ray or CT <strong>orbit</strong> and paranasal sinuses were taken<br />

in all cases of or suspected <strong>orbit</strong>al cellulitis. Both<br />

clinical improvement and improvement in vision<br />

were considered in outcome measures.<br />

Results<br />

Hundred and ten cases of <strong>orbit</strong>al cellulitis were<br />

reviewed. Seventy seven patients had preseptal<br />

cellulitis and thirty three patients had post septal<br />

cellulitis. It was noted that all cases with<br />

suspected <strong>orbit</strong>al cellulitis and cases of preseptal<br />

cellulitis in the pediatric age group were<br />

admitted. Adult patients with preseptal cellulitis<br />

were admitted if there was tense swelling of the<br />

lids with inability to open the lids, lid abscess,<br />

systemic toxemia or poor response to therapy<br />

with oral antibiotics.<br />

Age and sex distribution<br />

Among patients with preseptal cellulitis, 78%<br />

(n=58) were children while adults accounted for<br />

25% (n=19) of cases. The mean age was 3.62 yrs<br />

and 34.2 yrs in the pediatric and adult group,<br />

respectively. Sex distribution was equal in adults<br />

with male preponderance in children. In patients<br />

with <strong>orbit</strong>al cellulitis, 58% (n=19) were adults<br />

while children accounted for 42% (n=14) of cases.<br />

The mean age was 4yrs and 45 yrs in the pediatric<br />

and adult group respectively. Sex distribution<br />

was equal in children with male preponderance<br />

in adults.<br />

Predisposing factors<br />

Important factor predisposing to both clinical<br />

entities was injury, 21% in preseptal cellulitis and<br />

24% in <strong>orbit</strong>al cellulitis. In children, additional<br />

predisposing factors noted were insect bite (10%),<br />

molluscum contagiosum of lid with secondary<br />

bacterial infection and stye. Among adults, since<br />

most of them were laborers injury with stick and<br />

thorn while at work was the presdisposing factor<br />

in 24% cases and sinusitis in 15% patients. One<br />

patient had fungal pansinusitis.<br />

Duration of symptoms and hospitalization<br />

The average duration of symptoms for patients<br />

with preseptal cellulitis was four days in the<br />

adult group and 5.6 days in the pediatric group.<br />

The average duration of hospital stay was five<br />

days. Majority of them, 89.6% (n=69) were<br />

treated in ten days or less while 10.4% (n=8) cases<br />

were hospitalized for a longer duration. Visual<br />

acuity at presentation was better than 20/60 in<br />

most of the patients in the adult age group.<br />

In those with postseptal cellulitis, the average<br />

duration of symptoms was nine days in the adult<br />

group and 11 days in the pediatric group.<br />

Patients who presented late and those with<br />

associated sinusitis had increased ocular<br />

morbidity. The average hospital stay was 13.69<br />

days. Larger proportion of patients, 61.6% (n=19),<br />

had a prolonged hospital stay of more than 10<br />

days. Visual acuity at presentation was less than<br />

20/60 in most of them except in two cases who<br />

had visual acuity of 20/20. Three patients<br />

couldn’t perceive light at presentation.<br />

Blood culture<br />

Blood was cultured only in patients with<br />

suspected septicemia; 17 patients with preseptal<br />

cellulitis and all cases with <strong>orbit</strong>al cellulitis. There<br />

was no growth in the former group, while<br />

organisms were isolated in two cases of <strong>orbit</strong>al<br />

cellulitis.<br />

Conjunctival/wound swab<br />

Among the culture positive patients,<br />

Staphylococcus aureus was the most common


ORBIT/ PLASTIC SURGERY SESSION-II<br />

421<br />

Organism isolated<br />

Table-1: Organisms isolated<br />

Preseptal cellulitis<br />

number percentage<br />

Staphylococcus aureus 25 52<br />

Streptococcus pyogenes 8 17<br />

Bacillus anthracis 7 15<br />

Enterobacter 4 8<br />

Acinetobacter 2 4<br />

Pseudomonas aeruginosa 2 4<br />

Methicillin resistant<br />

Orbital cellulitis<br />

number percentage<br />

staphylococcus aureus 10 39<br />

Coagulase negative staphylococcus 6 23<br />

Staphylococcus aureus 4 15<br />

Streptococcus pyogenes 4 15<br />

Aspergillus 1 4<br />

Klebsiella 1 4<br />

Drugs<br />

Table-2: Drugs used for treatment<br />

Preseptal Cellulitis<br />

Children<br />

Adult<br />

Crystalline Penicillin 46 12<br />

Gentamicin 50 13<br />

Cloxacillin 7 1<br />

Metronidazole 4 4<br />

Amoxicillin 4 0<br />

Ampicillin 3 2<br />

Cephalexin 2 0<br />

Ceftriaxone 1 4<br />

Ciprofloxacin 1 0<br />

Orbital Cellulitis<br />

Children<br />

Adult<br />

Crystalline Penicillin 9 14<br />

Gentamicin 12 16<br />

Cloxacillin 6 3<br />

Ampicillin 1 1<br />

Ceftazidime 1 1<br />

Cefotaxime 0 1<br />

Vancomycin 1 0<br />

Ciprofloxacin 0 1<br />

organism isolated in both groups. Wound swab<br />

culture was positive in 78.78% cases (n=26) of<br />

post septal cellulitis. MRSA was cultured from<br />

39% cases followed by coagulase negative<br />

staphylococcus (23%) and staphylococcus aureus<br />

(15%). The other organisms isolated were<br />

streptococcus pyogenes, klebsiella and<br />

aspergillus (Table 1). Conjunctival and wound<br />

swab cultures showed no growth in 52% of<br />

patients of preseptal cellulitis and 21.22% of<br />

<strong>orbit</strong>al celllulitis.<br />

Anthrax prevalence<br />

Five percent (n=3) of children and 21% (n=4) of<br />

adults presented with cutaneous anthrax<br />

contributing to the preseptal cellulitis. None of<br />

the patients with <strong>orbit</strong>al cellulitis had such<br />

lesions.<br />

Radiological investigations<br />

In patients with preseptal cellulitis radiological<br />

investigations were done only in whom there<br />

was a suspicion of spreading cellulitis, to rule out<br />

<strong>orbit</strong>al cellulitis and sinusitis. No abnormality<br />

was detected in patients in whom these<br />

investigations were performed.<br />

Evidence of haziness of one or more sinuses<br />

associated with <strong>orbit</strong>al cellulitis was present in<br />

plain PNS roentgenograms and CT scans of 15%<br />

patients. While sinusitis was the most common<br />

radiological finding in the adult group, lid<br />

abscess, intraconal abscess and panophthalmitis<br />

were the findings seen on radio-imaging in the<br />

pediatric group.<br />

Treatment<br />

<strong>All</strong> patients were treated with parenteral<br />

antibiotics. The following table display the<br />

antibiotics used. Crystalline Penicillin and<br />

Gentamicin were the most frequently used<br />

antibiotics in both groups of patients. Other<br />

antibiotics were substituted or added for some<br />

patients based on the culture sensitivity reports<br />

and in whom response was poor even after four<br />

days to one week of therapy (Table-2). Surgical<br />

treatment in the form of incision and drainage of<br />

abscess was done in patients with lid or <strong>orbit</strong>al<br />

abscess.<br />

Ocular complications<br />

In preseptal cellulitis patients, associated<br />

complications in the form of facial cellulitis and<br />

lid abscess were seen in 8 children and 2 adults.<br />

In children two cases each of acute dacryocystitis,<br />

lid abscess and facial cellulitis were noted.<br />

Complications were more frequent in the<br />

postseptal group, in adults in the form of<br />

retrobulbar abscess, lid and scleral abscess,<br />

choroiditis, panophthalmitis, papillitis and


422 AIOC 2009 PROCEEDINGS<br />

retinal detachment. Children with <strong>orbit</strong>al<br />

cellulitis had lid abscess, intraconal abscess and<br />

panophthalmitis as associated complications.<br />

Clinical outcome<br />

A majority of patients in the preseptal group<br />

showed clinical improvement with treatment. At<br />

initial presentation itself, visual acuity remained<br />

unaffected in most of these patients. In the<br />

postseptal group, improved outcome, either<br />

clinical or visual was seen in 60.60% (n=20) cases.<br />

Adults had slightly better outcome; 63%<br />

improved, while in children improvement was<br />

seen only in 57% cases.<br />

Discussion<br />

Amongst the cases of <strong>orbit</strong>al cellulitis, preseptal<br />

celullitis constituted 70% and postseptal cellulitis<br />

30%. Children constituted majority of cases with<br />

preseptal cellulitis while the more serious <strong>orbit</strong>al<br />

cellulitis was more frequently seen in the adult<br />

population. Staphylococci followed by<br />

streptococci were the leading causative<br />

organisms in our series which is similar to other<br />

previous reports. 1,3 Thirty nine percent cases with<br />

postseptal cellulitis were caused by methicillin<br />

resistant staphylococcus aureus (MRSA). But<br />

none of these patients had recent hospitalization<br />

implying that the infection was community<br />

acquired (CA-MRSA). Another study has shown<br />

that CA-MRSA is emerging as a common cause<br />

of preseptal cellulitis. 4<br />

Bacillus anthracis was isolated from seven cases<br />

(15%) with preseptal cellulitis. The significance is<br />

that anthrax of the eyelid can lead to cicatrisation<br />

and ectropion 5-7 In our series all patients<br />

responded well to intravenous penicillin and<br />

didn’t develop complications.<br />

In older series, Computerized tomography<br />

helped in diagnosis when clinical features were<br />

not yet marked, aided in localizing the pathology<br />

to the anatomical spaces in the <strong>orbit</strong> and ruling<br />

out any associated sinusitis. 2,8 In our series, CT<br />

scan aided to diagnose intraconal and extraconal<br />

<strong>orbit</strong>al abscess in two patients and to diagnose<br />

panophthalmitis in two cases with <strong>orbit</strong>al<br />

cellulitis. <strong>All</strong> cases were empirically treated with<br />

intravenous penicillin and gentamicin to cover<br />

both gram positive and negative organisms.<br />

Cephalosporins, vancomycin and other<br />

antibiotics were given based on the sensitivity<br />

pattern, and if there was no clinical improvement<br />

with empirical therapy. Case records of patients<br />

in the recent past indicate the need for switching<br />

on to higher generation antibiotics, forty-five<br />

percent cases in <strong>orbit</strong>al cellulitis and fifteen<br />

percent cases in pre-septal cellulitis group. This<br />

may be due to the change in the sensitivity<br />

pattern of the organisms.<strong>All</strong> patients with<br />

preseptal cellulitis resolved without any<br />

sequelae. Ocular complications occurred in the<br />

postseptal group. Six patients lost vision due to<br />

postseptal cellulitis.<br />

Based on this nine years review, it can be<br />

concluded that preseptal cellulitis remains the<br />

commonest among <strong>orbit</strong>al infections of which<br />

Staphylococci and Streptococci are the most<br />

common causative organisms. Communityacquired<br />

MRSA is often implicated in <strong>orbit</strong>al<br />

cellulitis which is associated with more ocular<br />

morbidity and prolonged hospital stay. This long<br />

term retrospective study has helped in<br />

identifying emerging organisms causing <strong>orbit</strong>al<br />

infections and their sensitivity patterns. It<br />

indicates the need for modifying our empirical<br />

antimicrobial therapy, especially in <strong>orbit</strong>al<br />

cellulitis.<br />

1. Liu IT, Kao SC, Wang AG, Tsai CC, Liang CK, Hsu<br />

WM. Preseptal and <strong>orbit</strong>al cellulitis: A 10-year<br />

review of hospitalised patients. J Chin Med Assoc.<br />

2006;69:415-22.<br />

2. Bergin DJ, Wright JE. Orbital cellulitis. Br J<br />

Ophthalmol. 1986;70:174-8.<br />

3. Hodges E, Tabbara KF. Orbital cellulitis: review of<br />

23 cases from Saudi.<br />

4. Arabia. Br J Ophthalmol. 1989;73:205-8.<br />

5. Blomquist PH. Methicillin-resistant Staphylococcus<br />

aureus infections of the eye and <strong>orbit</strong>. Trans Am<br />

References<br />

Ophthalmol Soc. 2006;104: 322-45.<br />

6. Thappa DM, Karthikeyan K, Rao VA. Cutaneous<br />

anthrax of the eyelid. <strong>India</strong>n J Dermatol Venereol<br />

Leprol. 2003;69:55.<br />

7. Soysal HG, Kirath H, Recep OF. Anthrax as the<br />

cause of preseptal cellulitis and cicatricial ectropion.<br />

Acta Ophthalmol Scand. 2001;79:208-9.<br />

8. Amraoui A, Tabbara KF, Zaghloul K. Anthrax of the<br />

eyelids. Br J Ophthalmol. 1992;76:753-4.<br />

9. Zimmerman RA, Bilaniuk LT. CT of Orbital<br />

Infection and Its Cerebral Complications. AJR. 1980;<br />

134:45-50.


ORBIT/ PLASTIC SURGERY SESSION-II<br />

423<br />

AUTHORS’S PROFILE:<br />

DR. ASHOK KUMAR GROVER: M.B.B.S.(’76), Maulana Azad Medical College, New Delhi;<br />

M.S. (’80), Dr. Rajendra Prasad Centre for Ophthalmic Science, AIIMS, New Delhi. He was on<br />

the faculty of Maulana Azad Medical College as chief of Oculo<strong>plastic</strong> service. Received the<br />

prestigious Col. Rangachari Award, AIOC. President Elect of Oculo<strong>plastic</strong> Association of <strong>India</strong>.<br />

Past president, Federation of Ophthalmic Research and Education Centers (<strong>India</strong>) and Delhi<br />

<strong>Ophthalmological</strong> <strong>Society</strong> (DOS). Presently, Chairman of the Dept. of Ophthalmology at Sir<br />

Ganga Ram Hospital, New Delhi.<br />

Surgical Techniques for Management of Symblepharon:<br />

A Retrospective Study<br />

Dr. Ashok Kr Grover, Dr. Pracheer R. Agarwal, Dr. Rituparna Baruah, Dr. Shaloo Bageja<br />

(Presenting Author: Dr. Pracheer R. Agarwal)<br />

Symblepharon is always associated with<br />

functional as well as cosmetic concern to the<br />

patient. Symblepharon occurs basically as a<br />

consequence of abnormal cicatricial processes or<br />

of erroneous placement of flaps in the<br />

conjunctival wound. Intervention is attempted<br />

once the inflammatory process is under complete<br />

control. In cases of abnormal position of lids due<br />

to symblepharon, correction of the conjunctival<br />

anomalies is to be dealt first followed by the<br />

correction of the palpebral part. The tension<br />

Chemical injury AM in situ Post op pic.<br />

caused by the subepithelial scar tissue and the<br />

Tenon’s capsule on the conjunctival surface is<br />

Pre and post operative pictures of limbal grafting<br />

released allowing it to return to its original place<br />

and the exposed defect is covered with a graft if<br />

required. Different treatment modalities have<br />

evolved for the same but applying the correct one<br />

at the correct time matters the most.<br />

To evaluate different surgical techniques for<br />

release of symblepharon.<br />

Symblepharon corrected with Mucus Membrane graft.<br />

Materials and Methods<br />

A retrospective analysis of the case records along<br />

with the photograph of patients of partial and<br />

complete symblepharon operated between<br />

February 2003 and October 2007 was done.<br />

31 patients operated during that period were<br />

included in the study. Case records were<br />

analysed to find the<br />

cause of the<br />

symblepharon, presenting<br />

state of the eye,<br />

stage of the disease<br />

process, associated<br />

relevant findings of the<br />

ocular surface,<br />

Partial symblepharon treatment received etc.<br />

Basic principle of surgically treating<br />

symblepharon though remains the same but<br />

operative extent and aggressive post surgical<br />

treatment varies with the cases.<br />

Simple release of symblepharon with<br />

approximation of conjunctival defect was used in<br />

4 cases. Z plasty or VY plasty was carried out in<br />

4 cases, mucous membrane grafting in 13,<br />

conjunctival grafting in 8 and amniotic<br />

membrane grafting in 2 cases.<br />

Results<br />

A total of 31 patients (20 males, 11 female) were<br />

operated on during that period. The average age<br />

at the time of <strong>surgery</strong> varied from 6 years to 74<br />

years.


424 AIOC 2009 PROCEEDINGS<br />

The underlying causes of symblepharon were<br />

chemical burns (14), thermal burns (3),<br />

mechanical trauma (8), congenital (2) and<br />

previous surgical procedure (4).<br />

Clinical success was assessed in the follow up<br />

period of 6 months to 5 years. The results were<br />

gratifying in all groups with successful release of<br />

symblepharon and reformation of fornix.<br />

One of the patients where Z plasty was done<br />

required a later mucous membrane graft.<br />

Recurrence occurred in 3 cases where chemical<br />

burn was the aetiological factor.<br />

1. Honavar SG. Amniotic membrane transplantation<br />

for ocular surface reconstruction. Ophthalmology.<br />

2000;107:975-9.<br />

2. Shi W. Management of severe ocular burns with<br />

symblepharon. Graefes Arch Clin Exp Ophthalmol.<br />

2008.<br />

Evisceration of the eyeball is a commonly<br />

performed technique, either for functional or<br />

for cosmetic reasons. Enucleation is mandatory<br />

in cases of intraocular tumors and may be<br />

preferred in situations wherein a risk of<br />

sympathetic ophthalmia exists, for example<br />

following trauma or multiple intraocular<br />

surgeries. In most other situations either<br />

enucleation or evisceration may be performed.<br />

Evisceration is preferred by many<br />

ophthalmologists since it is a quicker procedure<br />

and is believed to result in better cosmesis and<br />

implant motility. One of the problems with the<br />

traditional evisceration technique, however, is<br />

that it does not allow placement of a large-sized<br />

<strong>orbit</strong>al implant. Since volume replacement with<br />

an <strong>orbit</strong>al implant is one of the main<br />

determinants of a good cosmetic outcome,<br />

numerous modifications of the standard<br />

evisceration technique have been proposed to<br />

allow for larger <strong>orbit</strong>al implant placement. We<br />

describe our results with one such technique, the<br />

References<br />

Discussion<br />

Symblepharon release can be achieved by the<br />

different techniques described by the different<br />

authors. But the basic principle remains the same.<br />

Grafting can be done with mucus membrane like<br />

buccal mucosa or conjunctiva, amniotic<br />

membrane.<br />

We got gratifying results in most of our cases<br />

where grafting was done with any of these<br />

material, however, chemical burn was notorious<br />

as it had its toll in 3 of our cases.<br />

Symblepharon can be managed with extremely<br />

gratifying results by a judicious choice of surgical<br />

technique.<br />

3. Kheirkhan A. Surgical strategies for fornix<br />

recontruction based on symblepharon severity. Am<br />

J ophthalmol 2008; 146(2): 266-275.<br />

4. Azuara–Blanco A. Amniotic membrane<br />

transplantation for ocular surface reconstruction. Br<br />

J O. 1999;83:1410-1.<br />

Orbital Implant Placement with A Modified Split-Sclera<br />

Technique of Evisceration<br />

Dr. C. P. Venkatesh, Prof Dinesh Selva<br />

(Presenting Author: Dr. C. P. Venkatesh)<br />

modified split-sclera technique with optic nerve<br />

disinsertion, that allows placement of large sized<br />

<strong>orbit</strong>al implants.<br />

Materials and Methods<br />

This was a retrospective, interventional case<br />

series. Patients posted for evisceration or for<br />

secondary <strong>orbit</strong>al implant placement following<br />

previous evisceration <strong>surgery</strong> were included in<br />

the study. Following detailed informed consent,<br />

the modified split-sclera technique was<br />

performed. In the primary technique, following<br />

standard evisceration, 2 oblique cuts were made<br />

in the sclera starting anteriorly and extending to<br />

the equator at 5 and 11o’clock. A circumferential<br />

incision was then made around the optic nerve<br />

head, disinserting the optic nerve from the sclera.<br />

Two other incisions were made at 7 and 2 o’clock<br />

starting posteriorly and extending to the equator.<br />

The <strong>orbit</strong>al implant (PMMA acrylic implants in<br />

all cases) was placed behind the sclera into the<br />

<strong>orbit</strong>al fat. A 20 or 22mm implant were used in


ORBIT/ PLASTIC SURGERY SESSION-II<br />

425<br />

all cases. The sclera was closed in doublebreasted<br />

fashion in front of the implant and the<br />

Tenon’s capsule and conjunctiva were then<br />

closed in layers. A similar procedure was<br />

followed in the secondary cases. Post-operative<br />

care included a tight pad over the operated eye<br />

for 5 days to reduce post-operative edema. A 5-<br />

day course of oral prednisolone 25mg and oral<br />

antibiotics were also given. After removing the<br />

pad, antibiotic ointment was prescribed twice a<br />

day. A custom-made ocular prosthesis was<br />

placed 6 weeks following the implant placement.<br />

Both implant and prosthesis motility were<br />

recorded subjectively.<br />

Results<br />

Eight patients (5 male; 3 female, age range 23-75<br />

years) underwent <strong>orbit</strong>al implant placement<br />

following evisceration over an 18 month period:<br />

6 primary and 2 delayed. <strong>All</strong> surgeries were<br />

uncomplicated. Follow-up period ranged from 3<br />

to 18 months. No case of implant exposure or<br />

extrusion were noted. Reasonable movement of<br />

the prosthesis was seen in all cases and all<br />

patients were satisfied with the procedure.<br />

Discussion<br />

To our knowledge this is the first series to report<br />

cosmetic and functional outcomes with this<br />

particular technique of evisceration. While<br />

numerous modifications of the spilt-sclera<br />

technique have been reported, the chief element<br />

in our technique is the optic nerve disinsertion.<br />

While this has been alluded to in the literature,<br />

we are unaware of any study that reports<br />

outcomes with this technique.<br />

The split-sclera technique with disinsertion of the<br />

optic nerve allows placement of large-sized<br />

<strong>orbit</strong>al implants thereby providing optimum<br />

volume augmentation and cosmesis.<br />

AUTHORS’S PROFILE:<br />

DR. KULDEEP RAIZADA: Presently Consultant Ocularistry, HOD, Dept. of Ocularistry, L V<br />

Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad-34, AP; Visiting Consultant,<br />

Naryana Netralaya, Bangalore, MGM Eye Institute, Raipur, Aditya Jyot Eye Hospital, Mumbai.<br />

E-mail: kuldeep_ocularist@gmail.com; Contact: 9849193447<br />

Management of Sliding Socket Syndrome<br />

Dr. Kuldeep Raizada, Dr. Deepa Raizada, Dr. Ramesh Murthy, Dr. Santosh G Honavar<br />

(Presenting Author: Dr. Kuldeep Raizada)<br />

Loss of an eye can lead to socket deformity<br />

which can be corrected with a well fitted<br />

custom made ocular prosthesis. How ever in<br />

certain conditions, these socket develops Sliding<br />

socket syndrome which is identified by the<br />

features of tilting up of prosthesis, frequent<br />

popping out of prosthesis, ectropion of the lower<br />

lid, very wide palpebral fissure, socket tilt<br />

outwards at the lower lid, position of implant<br />

very low in the socket, shallow inferior <strong>orbit</strong>al fat<br />

and forward bulge without presence of the<br />

implant.<br />

To evaluate the outcome of management of<br />

sliding socket syndrome “SSS” and their possible<br />

management with ocular and facial prosthesis.<br />

Materials and Methods<br />

Retrospective review of patients with sliding<br />

socket syndrome fitted with a custom made<br />

ocular prosthesis over a period of 3 years.<br />

Results<br />

On review success in terms of cosmesis and<br />

subjective improvement was achieved in 90% of<br />

cases while 10% of cases use of socket expander<br />

in the form of pressure conformer and later on<br />

prosthesis was performed.<br />

The procedures employed in 57 patient where<br />

tilting of prosthesis was 16% , frequent popping<br />

out of prosthesis 9%, prosthesis appears to be<br />

falling out 7%, ectropion of the lower lid 12%,<br />

very wide palpebral fissure 10.52%, socket tilt<br />

outwards at the lower lid 1.72%, position of<br />

implant very low in the socket 14%, inferior<br />

<strong>orbit</strong>al fat may sit low 10.52% and bulge forward<br />

without presence of the implant 19.2%. <strong>All</strong> the


426 AIOC 2009 PROCEEDINGS<br />

patients were fitted with custom made ocular<br />

prosthesis, tilting of prosthesis up was corrected<br />

in 14.2%, frequent popping out of prosthesis<br />

7.9%, prosthesis appears to be falling out 6.3%,<br />

ectropion of the lower lid 11.05%, very wide<br />

palpebral fissure 9.47%, socket tilt outwards at<br />

the lower lid 1.57%, position of implant sit very<br />

low in the socket 12.63%, inferior <strong>orbit</strong>al fat may<br />

sit low 9.47% and bulge forward without<br />

presence of the implant 17.36%.<br />

Discussion<br />

Patient with sliding socket syndrome have<br />

vertically shallow fornix and need to be<br />

evaluated carefully with a custom made ocular<br />

prosthesis. Most cases need a combination of<br />

modifications of special prosthesis.<br />

AUTHORS’S PROFILE:<br />

DR. (PROF.) V. P. GUPTA: MD, AIIMS, DNB. Worked as Lecturer, Reader, University College<br />

of Medical Sciences, Delhi. Head, Dept of Ophthal. Currently Professor and Head, Dept of<br />

Ophthal, University College of Medical Sciences & G.T.B. Hospital, Delhi-110095.<br />

Address: 275, Vihar, Delhi–110051. Contact: 30902962, 9818164208,<br />

E-mail: vpge15gtbh@yahoo.co.in<br />

Prospective Randomized Controlled Study To Compare The<br />

Results of Transcutaneous Versus Transconjunctival Frontalis<br />

Suspension for Congenital Ptosis with Poor Levator Function<br />

Frontalis suspension remains the gold<br />

standard for treatment of severe congenital<br />

ptosis with poor levator function. In brow<br />

suspension (frontalis suspension) ptosis repair<br />

ptotic lid is attached to the frontalis muscle using<br />

strips of sling material so that overaction of<br />

frontalis muscle elevates the ptotic lid. Bilateral<br />

congenital cases are most suited for this <strong>surgery</strong>.<br />

A variety of sling materials are available in the<br />

literature including autogenous fascia lata and<br />

synthetic materials. Fresh autogenous fascia lata<br />

still remains the most effective and most<br />

commonly used sling material. Fox’s pentagon<br />

technique and Crawford’s double triangle<br />

technique are two commonly used techniques.<br />

Autogenous fascia lata insertion using Fox’s<br />

pentagon technique is author’s preferred<br />

technique. Transcutaneous frontalis suspension<br />

using fascia lata has been the gold standard.<br />

Transconjunctival frontalis suspension (TCJFS) to<br />

elevate ptotic lid for congenital ptosis with poor<br />

levator action has been described as a safe and<br />

effective method. 1-2 However, only two studies<br />

are available in the literature. There is no study<br />

available from <strong>India</strong>. Therefore, TCJFS needs to<br />

be evaluated. This study was undertaken to<br />

Dr. V. P. Gupta<br />

(Presenting Author: Dr. V. P. Gupta)<br />

compare the results of transcutaneous versus<br />

transconjunctival frontalis suspension to elevate<br />

severe congenital ptosis with poor levator<br />

function.<br />

Materials and Methods<br />

This prospective randomized controlled study<br />

included 30 patients of severe congenital ptosis<br />

with poor levator function (


ORBIT/ PLASTIC SURGERY SESSION-II<br />

427<br />

transconjunctival approach for insertion of mini<br />

strip of fascia lata (TCJFS) was performed<br />

through two vertical incisions in tarsus at the<br />

junction of medial two third and lateral 1/3rd<br />

and medial 1/3rd with lateral 2/3rd. Two<br />

forniceal incisions were made, one each in lateral<br />

and medial aspect of superior fornix. The fascia<br />

lata strip was finally taken out through single<br />

central brow incision about 10 mm above brow.<br />

The ends of fascia lata strip were tied after<br />

adequate lid elevation was achieved as described<br />

by the author. 3 Brow incisions were sutured with<br />

6-0 prolene in both the groups. Frost suture was<br />

applied. Pad and bandage was done after putting<br />

antibiotic eye ointment. Frost suture was<br />

removed after 24 hours. Patients were put on<br />

frequent lubricating eye drops. Weekly followup<br />

was done for 4 weeks and then monthly for a<br />

minimum period of 3 months. Operative<br />

parameters included the ease of insertion of the<br />

strip, bleeding, number of skin incisions,<br />

duration of <strong>surgery</strong>, effectivity, surgeon’s control<br />

over the procedure etc. Postoperatively patients<br />

were evaluated for ptosis correction , over /<br />

undercorrection, lagophthalmos, lid lag,<br />

symmetry, cosmesis, any other complication etc.<br />

Results were compared with preoperative values<br />

and also with the other group. Follow-up period<br />

ranged from 3 months to 15 months. Criteria for<br />

successful results: just/desired correction or<br />

under/over correction (within 1 mm).<br />

Results<br />

There were 18 females and 12 males in the age<br />

group of 4 years to 20 years. There were 8<br />

bilateral and 7 unilateral cases (23 eyes ) in each<br />

group. <strong>All</strong> cases were congenital simple severe<br />

cases of ptosis. Degree of ptosis was 4-7 mm and<br />

levator action was 2-4 mm. Intraoperatively Gr I<br />

(TCTFS) required 5 skin incisions with more<br />

bleeding compared to single brow incision with<br />

less bleeding in Group-II. Duration of <strong>surgery</strong><br />

1. Dailey RA, Wilson DJ, Wobig JL. Transconjunctival<br />

frontalis suspension (TCFS). Ophthal Plast Reconstr<br />

Surg. 1991;7:289-97.<br />

2. Loff HJ, Wobig JL, Dailey RA. Transconjunctival<br />

References<br />

was 38 to 50 minutes in group I and 35 to 40<br />

minutes in group II. Surgeon had more control<br />

over the insertion of fascia lata in group I<br />

compared to group II though TCJFS was easier<br />

and simpler. Successful results were achieved in<br />

20/23 eyes (86.96%) in group I and 18/23 eyes<br />

(78.26%). Undercorrection of temporal part of lid<br />

was seen in 4 eyes in gr I. Functional<br />

undercorrection occurred in 2 eyes in each group.<br />

No entropion, exposure keratopathy,<br />

overcorrection, infection, granuloma or<br />

recurrence was encountered in either group. Skin<br />

scars were not cosmetically unsightly.<br />

Discussion<br />

Transconjunctival frontalis suspension for<br />

congenital severe ptosis with poor levator<br />

function was first described by Dailey et al in<br />

1991. 1 The technique was further clinically<br />

evaluated by Loff et al in 1999. 2 No other study<br />

is available in the literature. The present study<br />

evaluated and compared the operative and<br />

postoperative results of TCJFS with those of skin<br />

approach for frontalis suspension. The success<br />

rate of TCTFS (86.96%) was more than TCJFS<br />

(78.26%) though it was not statistically<br />

significant. TCJFS was simpler and less time<br />

consuming compared to TCTFS. However, at<br />

times author felt that TCJFS was a blind<br />

technique with lesser control over fascia lata<br />

insertion which might explain undercorrection of<br />

temporal part of lid in few cases. No major<br />

operative or postoperative complications were<br />

noted in either group. Skin scars in group I were<br />

of no concern to the patient.<br />

It is thus concluded that transconjunctival<br />

frontalis suspension appears to be a technically<br />

simpler, faster and effective technique for<br />

correction of congenital severe ptosis with poor<br />

levator function. It may be the viable alternative<br />

to transcutaneous approach of frontalis<br />

suspension.<br />

frontalis suspension: a clinical evaluation. Ophthal<br />

Plast Reconstr Surg. 1999;15: 349-54.<br />

3. Gupta VP. Brow suspension ptosis repair using<br />

mini fascia lata strip: a new modification. Proceed <strong>All</strong><br />

Ind Ophthal Soc Conf. 2001;7-8.


428 AIOC 2009 PROCEEDINGS<br />

AUTHORS’S PROFILE:<br />

DR. KULDEEP RAIZADA: Presently Consultant Ocularistry, HOD, Dept. of Ocularistry, L V<br />

Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad-34, AP; Visiting Consultant,<br />

Naryana Netralaya, Bangalore, MGM Eye Institute, Raipur, Aditya Jyot Eye Hospital, Mumbai.<br />

E-mail: kuldeep_ocularist@gmail.com; Contact: 9849193447<br />

Graduated Socket Expansion and Prosthesis<br />

Dr. Kuldeep Raizada, Dr. Deepa Raizada, Dr. Ramesh Murthy, Dr. Santosh G Honavar<br />

(Presenting Author: Dr. Kuldeep Raizada)<br />

Contracted socket can be defined as shrinkage<br />

of the fornices of the eye. It can be congenital<br />

(in the form of congenital anophthalmia or<br />

microphthalmia) or acquired following injury,<br />

surgical interventions, etc. Contracted sockets<br />

can be classified as mild, moderate and severe<br />

and depends on the severity of the shrinkage.<br />

Contracted sockets can be managed nonsurgically<br />

by graduated socket expanders and<br />

surgically by socket reconstruction <strong>surgery</strong>.<br />

To review the cases with contracted sockets that<br />

were managed by the use of graduated socket<br />

expander in the form of serial conformers/<br />

molded socket expander.<br />

Materials and Methods<br />

Patients with contracted socket who had<br />

undergone socket expansion therapy with<br />

graduated conformers, then fitted with custom<br />

made ocular prosthesis between January 2006<br />

and December 2007 were retrospectively<br />

reviewed.<br />

Results<br />

There were total of 15 patients with socket<br />

contraction associated with anophthalmia<br />

(congenital and acquired anophthalmia) and<br />

Ocular adnexal lymphomas present usually as<br />

a primary disease and a localized disease<br />

involving the <strong>orbit</strong>al soft tissue, conjunctiva, and<br />

eyelid and the lacrimal gland. 2,3 These tumors<br />

originate from B-cells in the eye and related<br />

microphthalmia who had undergone socket<br />

expansion therapy and fitted with customised<br />

prosthesis during this period. 8 patients had mild<br />

contracted socket and 6 had moderate socket<br />

contraction and 1 had severe socket contraction.<br />

Mean age was 30.33 (range was 5 to 65 years). <strong>All</strong><br />

patients were well managed by serial conformers<br />

of gradually increasing size followed by custom<br />

made ocular prosthesis fitting. Mean duration<br />

between date of presentation and date of<br />

prosthesis fitting was 13.8 weeks (range 6 weeks<br />

to 36 weeks). Satisfactory socket expansion to fit<br />

with a well-fitting prosthesis was achieved in all<br />

patients. Subjective perception of cosmesis with<br />

the custom ocular prosthesis was satisfactory in<br />

12 patients, 3 patients complained of smaller<br />

appearance with prosthesis compared to the<br />

other eye who were subsequently managed by<br />

cosmetic optics ( prescription of plus spherical<br />

and cylindrical lenses in front of prosthetic eye).<br />

Discussion<br />

Satisfactory socket expansion and cosmesis can<br />

be achieved by graduated conformers followed<br />

by custom made ocular prosthesis fitting in cases<br />

with mild to moderate contracted sockets.<br />

Ocular Adnexal Lymphoma - A Clinico-Pathological Study in<br />

Tertiary Eye Care Centre<br />

Dr Usha Kim, Dr. Mihir Mishra<br />

(Presenting Author: Dr. Mihir Mishra)<br />

tissues. Most patients with ocular adnexal<br />

lymphoma have stage IE disease, most common<br />

type being the extranodal marginal zone B-cell<br />

lymphoma of mucosa-associated lymphoid<br />

tissue (B-EMZL), although diffuse large cell B-cell


ORBIT/ PLASTIC SURGERY SESSION-II<br />

429<br />

lymphomas (B-DLCL), mantle cell lymphomas<br />

(B-MCL), follicular lymphomas may also be seen<br />

². Staging is done by REAL⁸ and Ann Arbor<br />

classification. Ocular adnexal lymphomas can be<br />

an initial presentation of NHL, either solitary or<br />

systemic and may present with symptoms of<br />

painless proptosis and/or diplopia due to an<br />

<strong>orbit</strong>al mass, conjunctival salmon patches, or<br />

ptosis from eyelid involvement, and may spread<br />

locally or disseminate systemically.² Management<br />

is by excisional biopsy, radiotherapy,<br />

chemotherapy, and various combinations.<br />

The purpose of this study is to focus on the<br />

clinical spectrum and staging of histologically<br />

proven ocular adnexal lymphoma and its<br />

correlation with final outcome.<br />

Materials and Methods<br />

Retrospective study was done from 1998 to 2007<br />

of all cases who presented to Aravind Eye<br />

Hospital, Madurai. Clinical data was analyzed<br />

for each patient with review of histopathological<br />

slides and medical records, scans in relation to<br />

epidemiological characteristics, clinical staging,<br />

histopathological staging and final outcome.<br />

Complete ophthalmologic assessment<br />

comprising of visual acuity, diplopia chart,<br />

description of functional symptoms, evaluation<br />

of eye movements, slit lamp findings, and ocular<br />

fundus findings for any associated extra ocular<br />

compression by the tumor was tabulated. The<br />

anatomic localization of ocular adnexal<br />

lymphoma was defined as <strong>orbit</strong>al, conjunctival,<br />

lacrimal gland, and eyelid, based on<br />

ophthalmologic examination and computed<br />

tomography (CT) or magnetic resonance imaging<br />

(MRI) of the <strong>orbit</strong>s. Full physical examination,<br />

hematological and chemical survey findings<br />

were noted. CT of the neck, chest, abdomen, and<br />

pelvis, bone marrow biopsy and aspiration<br />

cytology reports were also taken into<br />

consideration. <strong>All</strong> pathologic specimens were<br />

reviewed and the histopathological analysis was<br />

done based on the Revised European American<br />

Lymphoma (REAL) classification⁸ and Ann<br />

Arbor classification.<br />

Results<br />

Number of cases taken was 83 with male to<br />

female ratio being 2:1, <strong>orbit</strong>al lymphoma was the<br />

most common primary <strong>orbit</strong>al malignancy,<br />

median age was 56 years (1.5 to 83 years).<br />

Common age of presentation was 41-70 years in<br />

55 (66%), followed by 21-40 years in 15 (18.07%),<br />

71-90 in 10 (12.05%) and 0-20 years in 3 (3.62%).<br />

Unilateral presentation was in 76 (92%) and<br />

bilateral in 7 (8%) of the cases, with most<br />

common presentation clinically being a palpable<br />

mass 60 (72%), followed by proptosis in 46<br />

(55.4%) ,salmon patch in 23 (27.71%), ptosis in 22<br />

(26.71%), pain in 16 (19.27%), diminution of<br />

vision in 9 (10.84%) , diplopia in 9 (10.84%) and<br />

lymphadenopathy in 4 (4.82%) and no palpable<br />

mass in 23(27.71%). Most common location of<br />

palpable mass was superomedially in 24 (40%),<br />

superolaterally in 20 (33.3%), Superomedial and<br />

inferiorly in 6 (10.0%) and isolated inferiorly in<br />

10 (16.67%). The most common lid location being<br />

upper lid medially in 12 (60%), lowerlid medially<br />

in 5 (25%), upperlid laterally in 2 (20.0%) and<br />

lower lid laterally in 2 (20.0%). Most common<br />

conjunctival location was superiorly in 14 (60%),<br />

inferiorly in 6 (26.09%) and medially in 3<br />

(13.05%). Lacrimal gland involvement was in 7%<br />

of cases. According to Ann Arbor system, 77<br />

(92.8%) patients had stage I Extranodal Mantle<br />

zone lymphoma (stage IE), 2(2.4%) patients had<br />

stage IIE and 1 (1.2%) patient had stage IV<br />

Diffuse Large Cell Lymphoma, 2 (2.4%) patients<br />

had stage IV Mantle Cell Lymphom , and 1(1.2%)<br />

patient had stage III follicle cell lymphoma. Extra<br />

nodal marginal zone lymphoma 58 (69%) was the<br />

most common histopathological diagnosis<br />

according to the REAL Classification, followed<br />

by diffuse large cell lymphoma in 17 (20.48%),<br />

follicle centre lymphoma–I in 4 (4.82%), follicle<br />

centre lymphoma-II in 2 (2.41%) and Mantle cell<br />

lymphoma in 2 (24.1%).<br />

Disscussion<br />

In our case series of Ocular adenexal lymphoma,<br />

the male predominance is seen in contrast to<br />

many studies⁶, with most common presentation<br />

as a palpable mass ⁷, with most common<br />

histopathological type being extra nodal<br />

marginal zone lymphoma (B-EMZL )stage I ,<br />

similar data were obtained in other studies². Our<br />

study disclosed that age, sex, side of<br />

involvement, anatomic localization of the lesion,<br />

did not have prognostic significance during a<br />

follow-up period . HPE analysis and site of tumor<br />

is not statistically significant. Several major<br />

criteria must be considered in the initial<br />

assessment of the disease like the histopathologic


430 AIOC 2009 PROCEEDINGS<br />

subtype of lymphoma; extension of the disease,<br />

inside and beyond the periocular region;<br />

prognostic factors related to the patient and to<br />

the disease; the impact of the ocular adnexal<br />

lymphoma on the eye(s) and visual function.<br />

Vision is rarely affected except in cases of large<br />

tumors. Longer followup is required for<br />

detecting systemic manifestation and clinical<br />

staging is an important predictor for associated<br />

nonocular systemic disease for which extensive<br />

work up is required to rule out non-ocular<br />

1. Rootman J, Chang W, Jones D. Distribution and<br />

differential diagnosis of <strong>orbit</strong>al disease. In: Rootman<br />

J, ed. Diseases of the Orbit. Philadelphia, PA:<br />

Lippincott Williams and Wilkins 2003:53-85.<br />

2. Coupland SE, Krause L, Delecluse HJ, et al.<br />

Lymphoproliferative lesions of the ocular adnexa:<br />

analysis of 112 cases. Ophthalmology. 1998;105:1430-<br />

41.<br />

3. Nakata M, Matsuno Y, Katsumata N, et al.<br />

Histology according to the Revised European-<br />

American Lymphoma Classification significantly<br />

predicts the prognosis of ocular adnexal lymphoma<br />

Leukemia Lymphoma. 1999;32:533–543.<br />

4. Coupland SE, Hummel M, Stein H. Ocular adnexal<br />

lymphomas: five case presentations and a review of<br />

References<br />

disease. A multidisciplinary approach to ocular<br />

adnexal lymphoma by a team composed of<br />

hematologists, radiotherapists, and<br />

ophthalmologists is mandatory. Various<br />

conventional treatment modalities can be<br />

proposed for ocular adnexal lymphoma,<br />

including single-agent or combination<br />

chemotherapy regimens, radiotherapy, and<br />

monoclonal anti-CD20 antibody or interferon<br />

immunotherapy depending on the stage of the<br />

disease.<br />

the literature. Surv Ophthalmol 2002;47:470-90.<br />

5. Norton AJ. Monoclonal antibodies in the diagnosis<br />

of lymphoproliferative diseases of the <strong>orbit</strong> and<br />

<strong>orbit</strong>al adnexae. Eye 2006;20:1186-8.<br />

6. Marin Nola, Adrian Lukenda et. al. Outcome and<br />

Prognostic Factors in Ocular Adnexal Lymphoma,<br />

Croatian Medical Journal 2004;45:328-32.<br />

7. Jenkins C, Rose GE, Bunce C, Cree I, Norton A,<br />

Plowman PN, et al. Clinical features associated with<br />

survival of patients with lymphoma of the ocular<br />

adnexa. Eye 2003;17:809-20.<br />

8. Harris NL, Jaffe ES, Stein H, et al. A revised<br />

European-American classification of lymphoid<br />

neoplasms: a proposal from the International<br />

Lymphoma Study Group. Blood 1994;84:1361–92.

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