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Annual Report 2008-09 - Austin Health

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Research<br />

<strong>Austin</strong> <strong>Health</strong>’s culture of medical, research and teaching excellence combine<br />

to offer our patients access to rare advantages. Working in collaboration, our<br />

researchers and clinicans develop and test pioneering surgical procedures and<br />

newly-created drug therapies with promising results.<br />

The newly established <strong>Austin</strong><br />

LifeSciences brings together<br />

major institutes to form a<br />

research powerhouse in<br />

Heidelberg, already designated as<br />

a Victorian biotechnology precinct.<br />

They include hospital and The University<br />

of Melbourne departments of medicine,<br />

surgery, psychiatry and physiotherapy,<br />

the National Stroke Research Institute,<br />

Ludwig Institute for Cancer Research,<br />

Brain Research Institute, Australian<br />

Centre for Posttraumatic Mental <strong>Health</strong>,<br />

Institute for Breathing and Sleep,<br />

Epilepsy Research Centre and the<br />

Parent-Infant Research Institute. The<br />

multidisciplinary alliance consists of<br />

world-class scientific leaders conducting<br />

research in cancer, neurosciences,<br />

transplantation, heart disease,<br />

hypertension, immunology vaccines,<br />

endocrinology and sleep disorders.<br />

In addition, <strong>Austin</strong> <strong>Health</strong> is host to the<br />

Nucleus Network, which conducts early<br />

phase clinical trials in new medications.<br />

The following pages include brief<br />

highlights of a sample of research<br />

achievements in <strong>2008</strong>-<strong>09</strong>.<br />

CANCER MEDICINE: JOINT AUSTIN/<br />

LUDWIG ONCOLOGY UNIT<br />

<strong>Austin</strong> <strong>Health</strong>’s team plays both a<br />

national and international leadership<br />

role in the treatment and research<br />

of cancer. Prof Jonathan Cebon and<br />

Assoc Prof Ian Davis have developed<br />

approaches for harnessing the immune<br />

system to attack unique targets on<br />

cancer cells. These studies have led<br />

to substantial grant support from the<br />

NHMRC, Melanoma Research Alliance<br />

and Victorian Cancer Agency (VCA) for<br />

pioneering work into targets shared<br />

with germ cells and stem cells within<br />

cancer. Assoc Prof Ian Davis has<br />

pioneered new anti-cancer treatments,<br />

leading several international clinical<br />

trials with drugs that target molecular<br />

pathways in kidney cancer and the<br />

immune-stimulating protein interleukin<br />

IL-21 in melanoma. These trials<br />

together with his comprehensive<br />

laboratory research program into<br />

cancers of the genito-urinary tract<br />

have been recognized through research<br />

fellowships from both the NHMRC and<br />

VCA. Dr Niall Tebbutt is an international<br />

leader for the clinical research into<br />

bowel and upper gastro-intestinal<br />

(GI) cancers. He designed the MAX<br />

study, the largest study ever run by<br />

the Australasian GI Trials Group and<br />

initiated international collaboration<br />

with the UK. He also initiated other<br />

studies in advanced colorectal cancer<br />

involving novel combinations of biologic<br />

agents such as the DUX study (dual<br />

targeting by cetuximab and erlotinib)<br />

and the Vengeance study (dual targeting<br />

by bevacizumab and AMG386). He is<br />

a leading recruiter to multiple clinical<br />

trials of novel therapies and coauthored<br />

two New England Journal of<br />

Medicine publications establishing a<br />

survival benefit for cetuximab in k-ras<br />

wild type chemotherapy refractory<br />

colorectal cancer.<br />

CHRONIC FATIGUE SYNDROME (CFS)<br />

Paediatrician Dr Lionel Lubitz and<br />

exercise physiologist Brett Gordon’s<br />

work on the role of graduated exercise<br />

in CFS was published in The Journal<br />

of Paediatrics and Child <strong>Health</strong> in<br />

March. Dr Lubitz presented a study on<br />

the effect of CFS on family functioning<br />

at the International CFS meeting in Reno,<br />

<strong>Austin</strong> <strong>Health</strong> : <strong>2008</strong>-<strong>09</strong> ANNUAL REPORT<br />

23

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