Annual Report 2008-09 - Austin Health
Annual Report 2008-09 - Austin Health
Annual Report 2008-09 - Austin Health
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Research<br />
<strong>Austin</strong> <strong>Health</strong>’s culture of medical, research and teaching excellence combine<br />
to offer our patients access to rare advantages. Working in collaboration, our<br />
researchers and clinicans develop and test pioneering surgical procedures and<br />
newly-created drug therapies with promising results.<br />
The newly established <strong>Austin</strong><br />
LifeSciences brings together<br />
major institutes to form a<br />
research powerhouse in<br />
Heidelberg, already designated as<br />
a Victorian biotechnology precinct.<br />
They include hospital and The University<br />
of Melbourne departments of medicine,<br />
surgery, psychiatry and physiotherapy,<br />
the National Stroke Research Institute,<br />
Ludwig Institute for Cancer Research,<br />
Brain Research Institute, Australian<br />
Centre for Posttraumatic Mental <strong>Health</strong>,<br />
Institute for Breathing and Sleep,<br />
Epilepsy Research Centre and the<br />
Parent-Infant Research Institute. The<br />
multidisciplinary alliance consists of<br />
world-class scientific leaders conducting<br />
research in cancer, neurosciences,<br />
transplantation, heart disease,<br />
hypertension, immunology vaccines,<br />
endocrinology and sleep disorders.<br />
In addition, <strong>Austin</strong> <strong>Health</strong> is host to the<br />
Nucleus Network, which conducts early<br />
phase clinical trials in new medications.<br />
The following pages include brief<br />
highlights of a sample of research<br />
achievements in <strong>2008</strong>-<strong>09</strong>.<br />
CANCER MEDICINE: JOINT AUSTIN/<br />
LUDWIG ONCOLOGY UNIT<br />
<strong>Austin</strong> <strong>Health</strong>’s team plays both a<br />
national and international leadership<br />
role in the treatment and research<br />
of cancer. Prof Jonathan Cebon and<br />
Assoc Prof Ian Davis have developed<br />
approaches for harnessing the immune<br />
system to attack unique targets on<br />
cancer cells. These studies have led<br />
to substantial grant support from the<br />
NHMRC, Melanoma Research Alliance<br />
and Victorian Cancer Agency (VCA) for<br />
pioneering work into targets shared<br />
with germ cells and stem cells within<br />
cancer. Assoc Prof Ian Davis has<br />
pioneered new anti-cancer treatments,<br />
leading several international clinical<br />
trials with drugs that target molecular<br />
pathways in kidney cancer and the<br />
immune-stimulating protein interleukin<br />
IL-21 in melanoma. These trials<br />
together with his comprehensive<br />
laboratory research program into<br />
cancers of the genito-urinary tract<br />
have been recognized through research<br />
fellowships from both the NHMRC and<br />
VCA. Dr Niall Tebbutt is an international<br />
leader for the clinical research into<br />
bowel and upper gastro-intestinal<br />
(GI) cancers. He designed the MAX<br />
study, the largest study ever run by<br />
the Australasian GI Trials Group and<br />
initiated international collaboration<br />
with the UK. He also initiated other<br />
studies in advanced colorectal cancer<br />
involving novel combinations of biologic<br />
agents such as the DUX study (dual<br />
targeting by cetuximab and erlotinib)<br />
and the Vengeance study (dual targeting<br />
by bevacizumab and AMG386). He is<br />
a leading recruiter to multiple clinical<br />
trials of novel therapies and coauthored<br />
two New England Journal of<br />
Medicine publications establishing a<br />
survival benefit for cetuximab in k-ras<br />
wild type chemotherapy refractory<br />
colorectal cancer.<br />
CHRONIC FATIGUE SYNDROME (CFS)<br />
Paediatrician Dr Lionel Lubitz and<br />
exercise physiologist Brett Gordon’s<br />
work on the role of graduated exercise<br />
in CFS was published in The Journal<br />
of Paediatrics and Child <strong>Health</strong> in<br />
March. Dr Lubitz presented a study on<br />
the effect of CFS on family functioning<br />
at the International CFS meeting in Reno,<br />
<strong>Austin</strong> <strong>Health</strong> : <strong>2008</strong>-<strong>09</strong> ANNUAL REPORT<br />
23