CV - Department of Molecular and Cellular Biology - Harvard ...

Dept. of Molecular and Cellular Biology
Harvard University
52 Oxford Street
Cambridge, MA 02138
Tel: 617-495-5616 Fax: 617-496-9684
Email: gaudet@mcb.harvard.edu
RACHELLE GAUDET, PH.D.
http://www.mcb.harvard.edu/Gaudet/
EDUCATION
1993-1998 Ph.D. Studies in Molecular Biophysics and Biochemistry, Yale University
Thesis: Structural analysis of phosducin and its phosphorylation-regulated
interaction with transducin beta-gamma. December 1998.
1990-1993 B. Sc. in Biochemistry, Université de Montréal, Canada
RESEARCH AND PROFESSIONAL EXPERIENCE
July 2011-present Head Tutor, Molecular and Cellular Biology Concentration (Harvard
University)
July 2010-present Professor of Molecular and Cellular Biology, Harvard University
July 2010-July 2011 Co-Head Tutor, Molecular and Cellular Biology Concentration (Harvard
University)
July 2009-present Associate Member, Groupe d’Étude des Protéines Membranaires,
Montréal, Canada
July 2009-June 2010 Acting Co-Head Tutor, Chemical and Physical Biology Concentration
(Harvard University)
July 2006-June 2010 Associate Professor, Department of Molecular and Cellular Biology,
Harvard University
July 2005-2009 Co-Head Tutor, Biochemical Sciences Concentration (Harvard University)
July 2002-2006 Assistant Professor, Department of Molecular and Cellular Biology,
Harvard University
Fall 2000-present Tutor, Board of Tutors in Biochemical Sciences (Harvard University)
June 1998-July 2002 Postdoctoral fellowship in Don C. Wiley's laboratory, Harvard University
June 1994-June 1998 Graduate studies in Paul B. Sigler’s laboratory, Yale University
Spring 1996 Teaching assistant for MB&B700b (Advanced Biochemistry) Yale
University
Spring 1995 Teaching assistant for MB&B 301b (Principles of Biochemistry II) Yale
University
May-August 1993 Summer research internship in Jurgen Sygusch’s laboratory, Université de
Montréal, Canada
May-August 1992 Summer research internship in Norman Brisson’s laboratory, Université
de Montréal, Canada
Page 1 of 13

TEACHING EXPERIENCE
Rachelle Gaudet, PhD
Curriculum Vitae
Course Title (Fraction taught; Enrollment)
2011-2012
LS 100r Experimental Research in the Life Sciences (Project Faculty Lead)
2010-2011
MCB 56 Biochemistry & Physical Properties of Macromolecules (1.0; 17)
MCB 225 Interesting Questions in Physical Biology (0.1; 4)
2009-2010
MCB 56 Biochemistry & Physical Properties of Macromolecules (1.0; 25)
2008-2009
MCB 56 Biochemistry & Physical Properties of Macromolecules (1.0; 25)
2007-2008
MCB 156 Structural Biology of the Flow of Info in the Cell (0.5; 21)
MCB 225 Interesting Questions in Physical Biology (0.2 with F. Engert; 13)
MCB200hf Research Design and Methods: Graduate Study in MCB (0.25; 13)
Nanocourse Introduction to Protein Crystallography II (HMS) (0.25; 20)
2006-2007
MCB 156 Structural Biology of the Flow of Info in the Cell (0.5; 14)
MCB 225 Interesting Questions in Physical Biology (0.2 with F. Engert; 12)
MCB200hf Research Design and Methods: Graduate Study in MCB (0.25; 16)
Nanocourse Introduction to Protein Crystallography II (HMS) (0.25; 21)
2005-2006
MCB 156 Structural Biology of the Flow of Info in the Cell (0.5; 14)
MCB 210 Interesting Questions in Modern Biology (0.2 with F. Engert; n/a)
Chem 154 Crystal Symmetry, Diffraction, and Structure Analysis (0.1; n/a)
2004-2005
MCB 156 Structural Biology of the Flow of Info in the Cell (0.5; 11)
BS 56 Biochemistry & Physical Properties of Macromolecules (0.12; 47)
MCB 210 Interesting Questions in Modern Biology (0.2 with F. Engert; n/a)
2003-2004
MCB 156 Structural Biology of the Flow of Info in the Cell (0.5; 11)
MCB 200 Intro to Graduate Study in MCB (0.33 with D. Jeruzalmi; 14)
BS 56 Biochemistry & Physical Properties of Macromolecules (0.12; 60)
Chem 154 Crystal Symmetry, Diffraction, and Structure Analysis (0.1; n/a)
Additional noteworthy contributions
2011, 2012 Co-Lead 2-day PyMOL Nanocourse workshop (>35 students)
2009 Fully revise MCB56 (Physical properties of Macromolecules)
2006-2007 Establish a new graduate course (MCB200 Research Design and
Methods: Graduate Study in Molecular and Cellular Biology)
2003-2004 Establish a new advanced level course (MCB156 Structural
biology of the flow of information in the cell)
Fall 2000-Present Tutor, Board of Tutors in Biochemical Sciences (Harvard University)
Spring 1996 Teaching assistant for MB&B700b (Advanced Biochemistry)
(Yale University)
Spring 1995 Teaching assistant for MB&B 301b (Principles of Biochemistry II)
(Yale University)
Page 2 of 13

Rachelle Gaudet, PhD
Curriculum Vitae
RESEARCH AWARDS AND FELLOWSHIPS
2009 Semi-Finalist, HHMI Early Career Scientist Competition
2007-2010 Joseph Klingenstein Fellowship Award
2006-2011 American Cancer Society Research Scholar Grant
2005-2008 Basil O’Connor Starter Scholar Award
2004-2007 McKnight Scholar Award
2003-2007 AHA Scientist Development Grant
1998-2001 Ruth W. Sacks Postdoctoral Fellow of the Damon Runyon-Walter Winchell
Cancer Research Fund
1993-1997 NSERC 1967 Scholarship for Graduate Studies
1992 NSERC Undergraduate Summer Research Fellowship
ACADEMIC HONORS AND AWARDS
June 1999 Yale University Nominee for the 1999 CGS/University Microfilms
International Distinguished Dissertation Award in the Biological and Life
Sciences
October 1993 Excellence award in Biochemistry (Boehringer Mannheim Canada)
November 1992 Academic excellence award in chemistry from Fondation Lucien-Piché
October 1992 MDS Academic excellence award in biology
October 1992 Scholarship “In memory of the fourteen victims of École Polytechnique”
September 1992 Dean’s award from the Faculty of Arts and Sciences, Université de Montréal
October 1991 Scholarship “In memory of the fourteen victims of École Polytechnique”
September 1991 Merck Frosst award for academic excellence in chemistry and biochemistry
September 1990 Canada Scholarship, renewed in 1991 and 1992
RESEARCH PUBLICATIONS
H. Inada, E. Procko, M. Sotomayor and R. Gaudet (2012) Structural and Biochemical
Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human
TRPV4 Channel. Biochemistry, July 25 [Epub ahead of print]. PMCID in process.
G. Landouré, J. M. Sullivan, J. O. Johnson, C. H. Munns, Y. Shi, O. Diallo, J. R. Gibbs, R.
Gaudet, C. L Ludlow, K. H. Fischbeck, B. J. Traynor, B. G. Burnett and C. J. Sumner (2012)
Exome sequencing identifies a novel TRPV4 mutation in a CMT2C family.
Neurology 79, 192-4. PMCID in process.
M. Zimoń, J. Baets, M. Auer-Grumbach, J. Berciano, A. Garcia, E. Lopez-Laso, L. Merlini, D.
Hilton-Jones, M. McEntagart, A. H. Crosby, N. Barisic, E. Boltshauser, C. E. Shaw, G.
Landouré, C. L. Ludlow, R. Gaudet, H. Houlden, M. M. Reilly, K. H. Fischbeck, C. J. Sumner,
V. Timmerman, A. Jordanova and P. De Jonghe (2010) Dominant mutations in the cation
channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies.
Brain 133, 1798-1809. PMCID: PMC2912694
M. Sotomayor, W. A. Weihofen, R. Gaudet and D. P. Corey (2010) Structural determinants of
cadherin-23 function in hearing and deafness. Neuron 66, 85-100. PMCID: PMC2948466
G. Landouré, A. A. Zdebik, T. L. Martinez, B. G. Burnett, H. C. Stanescu, H. Inada, Y. Shi, A.
A. Taye, L. Kong, C. H. Munns, S. S. Choo, C. B. Phelps, R. Paudel, H. Houlden, C. L. Ludlow,
M. J. Caterina, R. Gaudet, R. Kleta, K. H. Fischbeck and C. J. Sumner (2010) Mutations in
TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nature Genetics 42, 170-4. PMCID:
PMC2812627
Page 3 of 13

Rachelle Gaudet, PhD
Curriculum Vitae
RESEARCH PUBLICATIONS (CONTINUED)
K. Artavanis-Tsakonas, W. A. Weihofen, J. M. Antos, B. I. Coleman, C. A. Comeaux, M. T.
Duraisingh, R. Gaudet, H. L. Ploegh (2010) Characterization and structural studies of the
Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. Journal of Biological
Chemistry 285, 6857-66. PMCID: PMC2825479
C. B. Phelps, R. R. Wang, S. S. Choo and R. Gaudet (2010) Differential Regulation of TRPV1,
TRPV3 and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat
Domain. Journal of Biological Chemistry, 285, 731-40. PMCID: PMC2804222
E. Procko and R. Gaudet (2008) Functionally Important Interactions between the Nucleotide-
Binding Domains of an Antigenic Peptide Transporter. Biochemistry 47, 5699-708.
C. B. Phelps, R. J. Huang, P. V. Lishko, R. R. Wang and R. Gaudet (2008) Structural analyses of
the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry 47, 2476-
2484. PMCID: PMC3006163
C. B. Phelps and R. Gaudet (2007) The Role of the N-Terminus and Transmembrane Domain of
TRPM8 in Channel Localization and Tetramerization. Journal of Biological Chemistry 282,
36474-80.
P. C. Sabeti, P. Varilly, B. Fry, J. Lohmueller, E. Hostetter, C. Cotsapas, X. Xie, E. H. Byrne, S.
A. McCarroll, R. Gaudet, S. F. Schaffner, E. S. Lander & The International HapMap Consortium
(2007) Genome-wide detection and characterization of positive selection in human populations.
Nature 449, 913-918. PMCID: PMC2687721
C. B. Phelps, E. Procko, P. V. Lishko, R. R. Wang, and R. Gaudet (2007) Insights into the Roles
of Conserved and Divergent Residues in the Ankyrin Repeats of TRPV Ion Channels. Channels
1, 148-151.
P. V. Lishko, E. Procko, X. Jin, C. B. Phelps and R. Gaudet (2007) The Ankyrin Repeats of
TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity. Neuron 54, 905-918.
C. Schlieker, W. A. Weihofen, E. Frijns, L. M. Kattenhorn, R. Gaudet and H. L. Ploegh (2007)
Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of
Deubiquitinating Enzymes. Mol. Cell 25, 677-687.
E. Procko, I. Ferrin-O’Connell, S.-L. Ng, and R. Gaudet (2006) Distinct structural and functional
properties of the ATPase sites in an asymmetric ABC transporter. Mol. Cell 24, 51-62.
X. Jin, J. Touhey, and R. Gaudet (2006). Structure of the N-terminal ankyrin repeat domain of
the TRPV2 ion channel. J. Biol. Chem. 281, 25006-25010.
E. Procko, G. Raghuraman, D. C. Wiley, M. Raghavan, and R. Gaudet (2005) Domain
boundaries are identified within the N-termini of TAP1 and TAP2 important for tapasin binding
and tapasin-mediated increase in peptide loading of MHC class I. Immunol. Cell Biol. 83, 475-
82.
S. Misaghi, P. J. Galardy, W. J. N. Meester, H. Ovaa, H. L. Ploegh, and R. Gaudet (2005)
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J. Biol. Chem.
280, 1512-1520.
S. Misaghi, Z.-Y. J. Sun, P. Stern, R. Gaudet, G. Wagner and H. L. Ploegh (2004) A structural
and functional analysis of the human cytomegalovirus US3 protein. J. Virol. 78, 413-423.
PMCID: PMC303419
Page 4 of 13

Rachelle Gaudet, PhD
Curriculum Vitae
RESEARCH PUBLICATIONS (CONTINUED)
M. Obin, B. Y. Lee, C. Thulin , G. Meinke, A. Bohm, R. H. Lee, R. Gaudet, J. A. Hopp, V. Y.
Arshavsky, B. M. Willardson and A. Taylor (2002) Ubiquitylation of Transducin (T) subunits:
Regulation by Phosducin. J. Biol. Chem. 277, 44566-44575.
R. Gaudet and D. C. Wiley (2001) Structure of the ABC ATPase domain of human TAP1, the
transporter associated with antigen processing. EMBO J. 20, 4964-4972. PMCID: PMC125601
B. E. Gewurz*, R. Gaudet*, D. Tortorella, E. W. Wang, H. L. Ploegh and D. C. Wiley (2001)
Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to
the class I molecule HLA-A2. Proc. Natl Acad. Sci. USA 98, 6794-6799. PMCID: PMC34432
*Contributed equally to this work.
M. Holm, C. S. Hardtke, R. Gaudet, and X.-W. Deng (2001) Identification and characterization
of a structural motif that confers specific interaction with the WD40 repeat domain of
Arabidopsis COP1. EMBO J. 20, 118-127. PMCID: PMC140188
R. Gaudet, J. R. Savage, J. N. McLaughlin, B. M. Willardson, and P. B. Sigler (1999) A
molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G Proteins
by phosducin. Mol. Cell 3, 649-660.
R. Gaudet, A. Bohm, and P. B. Sigler (1996) Crystal structure at 2.4 Å resolution of the complex
of transducin and its regulator, phosducin. Cell 87, 577-588.
REVIEWS AND BOOK CHAPTERS
E. Procko, R. Gaudet (2009) Antigen processing and presentation: TAPping into ABC
transporters. Curr Opin Immunol. 21, 84-91.
R. Gaudet (2009) Divide and conquer: high resolution structural information on TRP channel
fragments. J Gen Physiol. 133, 231-7. PMCID: PMC2654082
E. Procko, M. L. O’Mara, W. F. D. Bennett, D. P. Tieleman, R. Gaudet (2009) The mechanism
of ABC transporters: general lessons from structural and functional studies of an antigenic
peptide transporter. FASEB Journal 23, 1287-302.
R. Gaudet (2008) The ABCs of trans(porter) inhibition. Nat Chem Biol. 4, 454-5.
R. Gaudet (2008) TRP channels entering the structural era. J Physiol. 586, 3565-75. PMCID:
PMC2538826
R. Gaudet (2008) A primer on ankyrin repeat function in TRP channels and beyond. Molecular
BioSystems 4, 372–379. PMCID: PMC3006086
R. Gaudet (2006) Structural Insights into the Function of TRP Channels, In TRP Ion Channel
Function in Sensory Transduction and Cellular Signaling Cascades, W. Liedtke, and S. Heller,
eds. (Boca Raton, FL: CRC Press), pp. 349-359.
B. E. Gewurz, R. Gaudet, D. Tortorella, E. W. Wang and H. L. Ploegh (2001) Virus subversion
of immunity: a structural perspective. Curr. Opin. Immunol. 13, 442-450.
A. Bohm, R. Gaudet, and P. B. Sigler (1997) Structural aspects of heterotrimeric G-protein
signaling. Curr. Opin. Biotechnol. 8, 480-487.
INVITED LECTURES
International Workshop on Transient Receptor Potential Channels, Valencia, Spain, September
2012
Dept. of Biochem and Molec Pharmacol, UMASS Medical School, MA, February 2012
Page 5 of 13

Rachelle Gaudet, PhD
Curriculum Vitae
INVITED LECTURES (CONTINUED)
Ligand Recognition and Gating Gordon Research Conference, Ventura CA, January 2012
Symposium on Ligand-Gated Ion-Channels, Montreal, Canada, June 2011
Nano-machines in Health and Disease Workshop, NSLS, Brookhaven, NY, May 2011
Symposium in honor of Bernd Nilius, Leuven, Belgium, September 2010
Ion Channels Gordon Research Conference, New Hampshire, June 2010
MIT Biophysics Seminar Series, March 2010
Department of Physiology and Biophysics, Boston University School of Medicine, March 2010
ABC 2010, Innsbruck, Austria, March 2010
Biophysical Society Meeting, San Francisco, CA, February 2010
Dept. of Physiology, Columbia University, NY, January 2010
Structural Quantitative Biology Seminar, UC Berkeley, CA, December 2009
CCB/Biophysics Seminar Series, UCSF, CA, December 2009
Discovery on Target: Ion Channels as Therapeutic Targets, Boston, MA, November 2009
Dept. of Pharmacology, Yale University, October 2009
Department of Biochemistry, U. Toronto, Canada, July 2009
GRC “Mechanisms of Membrane Transport”, Maine, June 2009
GÉPROM Annual Symposium, Montréal, QC, Keynote Speaker, May 2009
UTSW Department of Pharmacology, Dallas, TX, May 2009
NIH Membrane Protein Interest Group, NIH, Bethesda, MD, December 2008
Dept. of Biochemistry, Brandeis University, Waltham, MA, December 2008
SfN2008 Minisymposium Sensory TRP channels: Molecular and Cellular Signal Integration,
Washington, DC, November 2008
Dept. of Physiology UCSF, November 2008
Workshop: Understanding pain from molecules to the brain, Baeza, Spain, October 2008
Gordon Research Conference on Membrane Transport Proteins, Il Ciocco Italy, July 2008
Quo Vadis Structural Biology, Harvard Medical School; May 2008
Dept. of Physiology and Biophysics, University of Washington, May 2008
Tufts University Medical School, Department of Biochemistry, January 2008
Vanderbilt University Department of Pharmacology, December 2007
Keystone Symposium on the TRP Channel Superfamily, Breckenridge, CO, September 2007
McKnight Conference on Neuroscience, Aspen, CO, June 2007
ABC2006 FEBS meeting, Innsbruck, Austria, March 2006
Dept. of Biochemistry, Tel Aviv University, Israel, March 2006
Minerva Gentner Symposia on TRP channels and calcium signaling, Eilat, Israel, February 2006
Pfizer Research and Technology Center, Cambridge, MA, November 2004
Department Biochemistry & Molecular Biophysics, Columbia University, February 2003
XIX Congress of the International Union of Crystallography, Geneva, Switzerland, August, 2002
Boston Structural Biology Retreat, Cambridge, MA, July 2002
Third Meeting on Antigen Processing and Presentation. Paris, France, May 2002
Department of Molecular and Cellular Biology, Harvard University. January, 2002
Department of Medicinal Chemistry, UNC, Chapel Hill, NC, December 2001
Division of Biophysics, University of Michigan, Ann Arbor, MI, December 2001
Faculty of Pharmacy, University of Toronto, Toronto, ON, December 2001
Hospital for Sick Children, Toronto, ON, December 2001
Département de Biologie, Université de Montréal. Montréal, QC, November 2001
Page 6 of 13

Rachelle Gaudet, PhD
Curriculum Vitae
INVITED LECTURES (CONTINUED)
Department of Molecular Biophysics and Biochemistry, Yale University, November 2001
Department of Physiology and Biophysics, Case Western Reserve University, November 2001
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore,
MD, October 2001
Department of Biochemistry, McGill University, Montréal, QC, October 2001
Department of Biochemistry, Stanford University, Palo Alto, CA, October 2001
Department of Molecular Physiology & Biological Physics, University of Virginia,
Charlottesville, VA, October 2001
Laboratory of Structural Biology, NIEHS, Research Triangle Park, NC, October 2001
Département de Biochimie, Université de Montréal. Montréal, QC, October 2001
Pfizer Discovery Technology Center, Cambridge, MA, March 2000
GRC, Second Messengers and Protein Phosphorylation, Meriden, NH, June 1999
Dept of Physiology and Biophysics, Mount Sinai School of Medicine, NY, March 1997
ASBMB Symposium, Molecular Recognition in G-protein Signaling, Keystone, CO, October
1996
DEPARTMENTAL SERVICES AND COMMITTEES
2010-present Junior Faculty Mentoring Committees (2)
2009-present
MCB Dept. Curriculum Committee
2008-2010 Seminar Committee
2007-2008 Biochemistry Faculty Search Committee
2003-2005 MCB Microchemistry Committee
2003-2004, 2004-2005, 2006-2007 MCB Junior Faculty Search Committee
2002-2003, 2004-2005 MCB Graduate Student Admissions Committee
UNIVERSITY SERVICES AND COMMITTEES
2011-2012 Standing Committee on Writing and Speaking
Fall 2008-present Program for Research in Science and Engineering (PRISE) Advisory Board
Fall 2008-present Mentor, HGWISE mentoring program for women graduate students
2005-present Life Sciences Education Committee
2007-present Standing Committee on Women
2006-2010 Freshman Advisor, Board of Freshman Advisors
2005-present Selection committees for undergraduate awards and fellowships (including
Herchel Smith, PRISE and Phi Beta Kappa)
Spring 2005 WISE task force subcommittee on Postdoctoral Fellows
SERVICES TO PROFESSIONAL ORGANIZATIONS
2011-present Member, NIH BPNS Study Section
2010 Ad Hoc member, NIH BPNS Study Section
2007, 2009 Ad Hoc reviewer, NIH special emphasis panel
2008-present Editorial Board Member, Pflügers Archiv - European Journal of Physiology
2008 Ad Hoc reviewer, ACS Genetics Mechanisms of Cancer study section
2006-present Member, American Society for Biochemistry and Molecular Biology
2003-2005 American Heart Association Immunology and Microbiology Study Section
1994-present Member, American Association for the Advancement of Science
Ad Hoc reviewer of many journals, including Nature, NSMB, Molecular Cell, PNAS, NAR,
EMBO Journal, Structure, JBC, Trends in Immunology
Page 7 of 13

TRAINEES AND ADVISEES
TRAINEES Dates (Current position) Project(s) and Other Notes
Graduate Students
Erik Procko
(MCB)
Ruiqi Rachel Wang
(Chem Bio)
2003-2009
(Postdoctoral Fellow with
David Baker, U. of
Washington)
2007-2009
(Graduate Student with
Tom Walz, Harvard
Medical School)
2009-present
Rachelle Gaudet, PhD
Curriculum Vitae
Thesis title: General Mechanisms for
ABC Transporters revealed by the
Transporter associated with Antigen
Processing
Additional project: Role of TRPV1
ankyrin repeats in TRPV1 temperature
sensitivity and calmodulin interactions
Biochemical characterization of the TRPV
ankyrin repeats - the TRPV3 and TRPV4
ankyrin repeats bind ATP and calmodulin
Luciann L. Cuenca
(BBS)
Structural and functional studies of
TRPV1
Lukas Bane (MCO) 2011-present Structural and functional studies of
NRAMP transporters
Monique Brewster 2011-present
Structural studies of the cytoplasmic
(MCO)
domains of TRPA1
Sriram Srikant (EPB) 2012-present Structure and evolution of ABC
transporters
Kenneth Skinner 2012-present
Structural Studies of TRP channels
(Chemical Biology)
Undergraduates
Aaron Huang 2002-2004 Toward a TAP1/TAP2 nucleotide-binding
domain heterodimer
Tiffany Hsieh 2002-2004
(MD, Columbia
University)
David Sola-Del Valle 2004-2005
(MD, Columbia
University )
Shelly S. Choo 2004-2006
(MD, Johns Hopkins
University)
Robert J. Huang 2005-2007
(Medical School, Duke
University)
Expression of the TRPV1 C-terminal
domain
Thesis title: Structure-function studies of
TRPA1, a thermo- and mechano-sensitive
ion channel
Hoopes Prize
Thesis title: Structural and Biochemical
Studies of the N-Terminal Region of the
Temperature-Sensing TRPV Ion Channels
Hoopes and Henderson Prizes
Co-author, JBC 2010 and one submitted
manuscript
Thesis title: Structural and Functional
Studies of the Ankyrin Repeats of TRPV
Ion Channels
Co-author, Biochemistry 2008
Page 8 of 13

Samer Haidar 2005-2009
(Medical School, McGill
University)
Albert Li 2006-2009
(NYU Medical School)
Vi Vu 2007-2009
(VES concentration, class
of 2010)
Rachelle Gaudet, PhD
Curriculum Vitae
Engineering Design Project title:
Inducing Dimeric Interactions Using
Leucine Zippers
HHMI program
Thesis title: Structural Studies of TRPV1
Activation by Capsaicin
Hoopes Prize, PRISE Fellow
Interaction of TRPV1 with calmodulin
HHMI program, PRISE Fellow
Alejandra Beristain-
Barajas
2007-2010
(Research technician)
Thesis title: Exploring the Molecular
Mechanisms of Pain:Structural and
Biochemical Studies on Nociceptor
Channel TRPA1, Ankyrin Repeat Domain
PRISE Fellow
Tianyi Zhu Summer 2006 Expression and purification of bacterial
Anne McCabe 2007-2011
(PhD student, Princeton)
Ahad Waraich Summer 2008
(U. Chicago Class of
2012)
Kevin C. Ni
2010-2012 (MD/PhD
student, Indiana U)
Nramp transporters
Thesis title: Studying the ion permeation
pathway of divalent metal transporter
NRAMP using site-directed mutagenesis
PRISE Fellow
Biochemical characterization of the
TRPM2 NUDIX domain and its
interaction with nucleotides
Leadership Alliance Intern
Thesis title: Structural insights into
asymmetric motor domains of the ABC
transporter TAP
PRISE Fellow
Robert Powers 2011-present Studies of Protocadherin-15 SNP
positively selected in the asian population
PRISE Fellow, Hershel Smith Fellow
Alexandra Rojek 2012-present Functional studies of NRAMP homologs
Erik Zheng 2012-present Structural Studies of TRPA1
PRISE Fellow
Emily Lingeman
Summer 2012 (U.
Wisconsin Madison Class
of 2014)
Postdoctoral Fellows
Xiangshu Jin 2003-2006
(Research Scientist,
Columbia University)
Christopher Phelps 2003-2009
(Principal Scientist,
GlaxoSmithKline)
Functional studies of NRAMP homologs
Leadership Alliance Intern
Structure determination of the TRPV1 and
TRPV2 ankyrin repeat domains
Functional and Structural Studies of
TRPM8
Structure of the TRPV6 ankyrin repeats
Functional studies of TRPV channels
Page 9 of 13

Wilhelm Weihofen 2005-2011
(Crystallography Group
Leader, Novartis)
Rachelle Gaudet, PhD
Curriculum Vitae
Structural studies of Nramp transporters
Structures of pathogen deubiquitinating
enzymes (collaboration with H.L. Ploegh)
Structures of cadherins important in
hearing (collaboration with D.P. Corey)
Sze Yi Lau 2008-present Structural determinants of TRPV1 and
calmodulin interaction
Functional studies of TRPM8
Marcos Sotomayor 2008-present
(co-sponsored by D.P.
Corey)
Structure and molecular dynamics of the
hair cell tip link cadherins (collaboration
with D.P. Corey) *HHW Fellow* *K99*
Ahmet Vakkasoglu 2009-present Structure and function of the TAP
Alex Peralvarez-
Marin
2010-2011
(Autonomous University of
Barcelona, Spain)
transporter
Production of TRPV channels for
structural studies *Marie Curie Fellow*
Ute Hellmich 2012-present TRPV channel structural studies *EMBO
Fellow*
Research Associates
Polina V. Lishko 2005-2007
(Assistant Professor,
Berkeley)
Establishing Electrophysiology
Developing a cysteine-less TRPV1 protein
Role of the TRPV1 ankyrin repeats in
TRPV1 function
Hitoshi Inada 2008-present Expression of TRP channels in insect cells
and yeast; evaluation using fluorescence
size exclusion chromatography
Crystallization and structure determination
of TRPV and TRPM channel domains
Research Assistants
Jason Touhey 2004-2006
(Hospitalist)
Structure of the TRPV2 ankyrin repeats
Co-author JBC 2006
Amanda McFedries 2008-2009
(Harvard MCO graduate
student)
Gavin MacKinnon Extension School Volunteer
2008-2009
(Medical Student, U.
Michigan)
Structure and function of the TAP
transporter
Cysteine-scanning mutagenesis of TRPV1
Page 10 of 13

Rachelle Gaudet, PhD
Curriculum Vitae
ADVISEES
Undergraduate Advising
Tutees in Biochemical Sciences
Beth Hochman (2000-2003)
Amara Lee Murray (2000-2003)
Uma Menon Sachdeva (2000-2003)
Kunal Sanghvi (2000-2003)
Craig Michael Alpert (2003-2006)
Annie Rui Zhang (2003-2006)
Timothy Cooks (2004)
Wei Kevin Gan (2005-2008)
Peter Cai (2006-2008)
James Watts (2006-2010)
Benjamin Philipson (2010-present)
Biology Concentration Advisees
Ariel Jordana Cohen (2002-2004)
Melkis Alvarez (2003-2006)
Caitlin Meghan McCord (2004-2007)
Marisa Harkins Flavin (2004-2007)
Graduate Student Advising
Qualifying Exam Committees
Alexander Wait (Biophysics, 2003)
JJ Miranda (MCB, 2003)
Ayellet Segré (MCB, 2003)
Tomokazu Sato (Biophysics, 2006)
Deborah de Jong McEwan (MCB, 2007)
Ian Ferrin-O'Connell (MCB, 2007)
Dina Fomina (MCB, 2008)
Entela Nako (MCB, 2008)
Sarah Miller (MCB, 2008)
Valerie Pivorunas (MCO, 2009)
Joshiawa Paulk (Chemical Biology, 2009)
Scott Chilton (MCO, 2010)
Jessica Liu (MCO, 2010)
John Srouji (MCO, 2010)
Andy Whynot (MCO, 2010)
Anna Puszynska (MCO, 2011)
Thesis Defense Committees
Michael A. Robinson (2004, Biophysics)
Vassilios Bezzerides (2004, Biophysics)
Michael Fitzgerald (2005, MCB)
Xiaohui Lu (2006, MCB)
JJ Miranda (2006, MCB)
Lindsay Marie Frost (Spring 2005)
Amy Ran Tao (Spring 2005)
Amanda Elizabeth Kiely (Spring 2005)
Nneka Nnaoke Ufere (2005-2008)
Freshman Advisees
Toomas Laarits (2006-2007)
Eliora Mariam Noetzel (2006-2007)
Tice Patrick Brown (2006-2007)
Ivy Pan (2007-2008)
Maria Maystrovskaya (2007-2008)
Yoke-Mun Sung (2007-2008)
Edward Kogan (2008-2009)
Gillian Chase (2008-2009)
Jocelyn Grace Karlan (2008-2009)
Cagla (Gamze) Seten (2009-2010)
Alena Tofte (2009-2010)
Lisa Wetstone (2009-2010)
Ayellet Segré (2006, MCB)
Daina Graybosch (2006, Chemistry)
Hua Wei (2006, Chemistry)
Laura Marcotte (2006, Biophysics)
Danaya Pakotiprapha (2008, MCB)
Charisse Crenshaw (2008, MCB)
Yan Qi (2009, Biophysics)
Deborah de Jong McEwan (2010, MCB)
Martin Samuels (2011, MCB)
Josh Baughman (2011, BBS)
Rou-Jia Sung (2011, MCB)
Sarah Miller (2011, MCB)
Dina Fomina (2011, MCB)
Ian Ferrin-O'Connell (2007-present, MCB)
Thesis Advisory Committees
Sharam Misaghi (2002-2005, BBS)
Xiaohui Lu (2002-2006, MCB)
JJ Miranda (2003-2006, MCB)
Ayellet Segré (2003-2006, MCB)
Matthew Call (2004-2007, Immunology)
Michael Fitzgerald (2004-2005, MCB)
Marie Spong (2005-2007, Chemistry)
Daina Graybosch (2005-2006, Chemistry)
Page 11 of 13

Rachelle Gaudet, PhD
Curriculum Vitae
Hua Wei (2005-2006, Chemistry)
Charisse Crenshaw (2006-2008, MCB)
Deborah de Jong McEwan (2007-2010, MCB)
Ian Ferrin-O'Connell (2007-2012, MCB)
Dina Fomina (2008-2011, MCB)
Entela Nako (2008-present, MCB)
Rou-Jia Sung (2008-2011, MCB)
Sarah Miller (2008-2011, MCB)
Yan Qi (2008-2009, Biophysics)
Kittikhun Wangkanont (2009-2011, CB)
Martin Samuels (2008-2011, MCB)
Valerie Pivorunas (2009-present, MCO)
Scott Chilton (2010-present, MCO)
Tina Liu (2010-present, BBS)
Jessica Liu (2010-present, MCO)
John Srouji (2010-present, MCO)
Andy Whynot (2011- 2011, MCO)
Jared Sprague (2011-present, HSDM)
Anna Puszynska (2011-present, MCO)
David Westwood (2011-present, CB)
Lincoln Pasquina (2011-present, BBS)
Neutral Advising (MCO program)
Julia Chung (2008-2009)
Zain Ali (2011-2012)
HGWISE Mentoring Program
Elizabeth Land Templeton
(Engineering Sciences, 2008-2009)
Aviva Presser
(Applied Math, 2008-present)
Emily Gardel
(Applied Physics, 2008-present)
Laura Brattain
(Bioengineering, 2009-present)
Elise Novitski
(Physics, 2010-present)
RESEARCH SUPPORT
Ongoing:
Gaudet (PI) 2/1/08 – 1/31/13
1R01GM081340
NIH/NIGMS
Structure and function of TRPV ion channels
Gaudet (coPI) 4/1/11 – 3/31/16
2R01DC002281 (Corey, PI)
NIH/NIDCD
Molecular Basis of Inherited Deafness
Computing resources grants:
Gaudet (Co-PI ) 1/1/2009 – 12/31/2010 renewed 1/1/2011-12/31/2011
TRAC MCB080015 (David P. Corey and Marcos Sotomayor, Co-PIs)
NSF Teragrid
Molecular Mechanisms of Hereditary Deafness and Pain Sensation (1,944,000 SUs in 2009,
1,700,000 SUs in 2011)
Gaudet (Co-PI) 10/1/2010 – 3/31/2011
PSCA00074 (David P. Corey and Marcos Sotomayor, Co-PIs)
Award for computer time on Anton at NRBSC/PSC
Resolving the Molecular Mechanisms of Calcium Binding to Cadherins Involved in Hearing and
Deafness (100,000 Anton node hours)
Page 12 of 13

Rachelle Gaudet, Ph.D.
Curriculum Vitae
Completed:
Gaudet (PI) 7/1/06 – 6/30/10 – extension to 6/30/11
Research Scholar Grant RSG-06-160-01-GMC
American Cancer Society
Structural studies of the TAP ABC transporter
Gaudet (PI) 7/1/07 – 6/30/10
Klingenstein Fellowship Award
The Esther A. & and Joseph Klingenstein Fund
Structural biology of temperature sensing by the TRPM8 channel
5-FY04-219 Gaudet (PI) 2/1/05-1/31/07 - extension to 1/31/08
March of Dimes
Basil O'Connor Starter Scholar Award
Structure determination of an Nramp transmembrane importer of divalent metals
Gaudet (PI) 7/1/04 – 6/30/07 - extension to 12/31/07
McKnight Scholar Award
McKnight Endowment Fund for Neuroscience
Structural studies of temperature-sensing TRP channels
SDG 0335134N Gaudet (PI) 7/1/03 – 6/30/07
Scientist Development Grant
American Heart Association (National)
Structural studies of the gating and regulation of the vanilloid subfamily of TRP ion channels
Page 13 of 13