1. Name Takehiko WADA First Name Last Name 2. Sex M 3 ... - IS3NA

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1. Name Takehiko WADA
First Name Last Name
2. Sex M
3. Date of Birth 03 Date 02 Month 1961 Year
4. Position Professor
5. Institution Institute of Multidisciplinary Research for Advanced Materials,
(IMRAM), Tohoku University
a. Postal Address 2-1-1, Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan
b. Telephone Number +81-22-217-5608
c. Fax Number +81-22-217-5608
d. E-mail Address hiko@tagen.tohoku.ac.jp
e. URL Address http://www.tagen.tohoku.ac.jp/labo/wada/index-j.html
6. Study Field / Current Study Theme
Chemical Biology, Nucleic Acid Chemistry, Bioorganic Chemistry, Artificial Nucleic Acids,
Biocompatible Polymers, Asymmetric Photochemistry, Supramolecular Asymmetric Photochemistry
7. Research Interest
Chemical Biology, Nano-biochemistry, Bioorganic Chemistry, Gene Therapy, Nucleic Acids
Chemistry, Life Science, Photochemistry, Entropy Control, Temperature/Pressure/Solvent Effects
upon Asymmetric Photoreactions
8. Educational Backgrounds (after high school)
B.A. Osaka University, Japan, March 1984, Applied Fine Chemistry
Ph. D. Osaka University, Japan, March 1989, Applied Fine Chemistry
9. Professional Backgrounds
1989-1995 Assistant Professor of Applied Fine Chemistry, Osaka University
1995-1997 Associate Professor of Molecular Chemistry, Osaka University
1997-2007 Associate Professor of Molecular Chem., Graduate School of Engineering, Osaka University
2007- Professor of IMRAM, Tohoku University.
Postdoctoral. Columbia University, NYC, NY, USA (Advisor: Nicholas J. Turro)
1989, Sep.-Nov.; 1990, July- Sep. 2001, Oct.-Dec.
2003-2007 PRESTO investigator, JST
10. Awards
Award for Encouragement of Research in Polymer Science, The Society of Polymer Science,
Japan (1993)
11. List of Publications (see the attached)
12. Hobby
Driving, Reading, and Playing tennis

(1) Original Paper
143. Highly Enantiomeric Supramolecular [4+4] Photocyclodimerization of 2-Anthracenecarboxylate
Mediated by Human Serum Albumin,
M. Nishijima, T. Wada, T. Mori, T. C. S. Pace, C. Bohne, and Y. Inoue,
J. Am. Chem. Soc., 129, 3478 (2007).
142. Supramolecular Photochirogenesis with Biomolecules. Mechanistic Studies on the Enantiodifferentiation
for the Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Bovine Serum Albumin,
M. Nishijima, T. Wada, T. C. S. Pace, A. Nakamura, T. Mori, C. Bohne, and Y. Inoue,
J. Org. Chem., 72, 2707 (2007) (Cover picture).
141. Inherently Chiral Molecular Clips: Synthesis, Chiroptical Properties, and Application to Chiral
Discrimination,
G. Fukuhara, S. Madenci, J. Polkowska, F. Bastkowski, F. Klärner, Y. Origane, M. Kaneda, T. Mori,
T. Wada, and Y. Inoue,
Chem.–Eur. J. 13, 2429 (2007) (Cover picture).
140. Enhanced Ternary 1:2 Host-Guest Complexation of Amino-γ-cyclodextrins with 2-Anthracenecarboxylic
Acid,
C. Yang, G. Fukuhara, A. Nakamura, Y. Origane, T. Mori, T. Wada, and Y. Inoue,
J. Inclusion Phenom. Macrocyclic Chem. in press.
139. Pharmacological Activity and Structural Analysis of a Benzamide (TKS159) and Its Optical Isomers in
an In Vitro Study and in an In Vivo Study in Mice,
J. Mizoguchi, T. Yanagi, K. Anzai, K. Kodama, O. Kamoda, C. Kamei, N. Kanehisa, Y. Kai, T. Wada,
and Y. Inoue,
Methods Find. Exper. Clin. Pharm. (Methods and Findings in Experimental and Clinical Pharmacology),
in press.
138. Active Control of DNA Recognition Behavior of α-Peptide Ribonucleic Acids Containing Basic Amino
Acid Residues by External Factors,
T. Wada, H. Sato, M. Kikkawa, and Y. Inoue,
Biopolym., in press.
137. DNA Recognition and Recognition Control of α-Peptide Ribonucleic Acids by External Factors.
T. Wada, M. Kikkawa, H. Sato, and Y. Inoue,
Nucleic Acids Res., in press.
136. Regioselective [2 + 2]-photocycloaddition reactions of chiral tetronates-influence of temperature,
pressure, and reaction medium,
M. Fleck, C. Yang, T. Wada, Y. Inoue, T. Bach,
Chem. Comm., 822 (2007).
135. Synthesis of peptide ribonucleic acids (PRNA) - DNA chimera and control of RNase H activity by
external factor.
T. Wada, Y. Maeda, N. Sawa, H. Sato, H. Chon, S. Kanaya, Y. Inoue,
Peptide Sci. 222 (2006).
134. Entropy-Controlled Supramolecular Photochirogenesis: Enantiodifferentiating Z-E Photoisomerization of
Cyclooctene Included and Sensitized by Permethylated 6-O-Modified β-Cyclodextrins,
G. Fukuhara, T. Mori, T. Wada, and Y. Inoue,
J. Org. Chem., 71, 8233 (2006).
133. Enantio-Differentiating Photo-Cyclodimerization of 2-Anthracene-Carboxylic Acid Mediated by
γ-Cyclodextrins with a Flexible or Rigid Cap,
C. Yang, A. Nakamura, T. Wada, and Y. Inoue,
Org. Lett., 8, 3005 (2006).
132. Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylic Acid Using a Chiral
N-(2-Hydroxymethyl-4-pyrrolidinyl)benzamide Template,
J. Mizoguchi, Y. Kawanami, T. Wada, K. Kodama, K. Anzai, T. Yanagi, and Y. Inoue,
Org. Lett., 8, 6051 (2006).
131. RNA Recognition and Recognition Control of -Peptide Ribonucleic Acids Containing Arginine
Residue by External Factors,
T. Wada, Y. Maeda, N. Sawa, H. Sato, S. Futaki, and Y. Inoue,
Nucleic Acid Res., 50, 75 (2006).

130. Solvent switching of stereoselectivity in [4 + 4] photocyclodimerization of 2-anthracenecarboxylic acid,
J. Mizoguchi, T. Wada, and Y. Inoue,
Chem. Lett. 35, 738 (2006).
129. Enantio-Differentiating Photo-Cyclodimerization of 2-Anthracene-Carboxylic Acid Mediated by
γ-Cyclodextrins with a Flexible or Rigid Cap,
C. Yang, A. Nakamura, T. Wada, and Y. Inoue,
Org. Lett., 8, 3005 (2006).
128. The first supramolecular photosensitization of enantiodifferentiating bimolecular reaction:
anti-Markovnikov photoaddition of methanol to 1,1-diphenylpropene sensitized by modified
β-cyclodextrin,
G. Fukuhara, T. Mori, T. Wada, and Y. Inoue,
Chem. Comm., 1712 (2006).
127. Switching of Product's Chirality in Diastereodifferentiating [2+2] Photocycloaddition of (E)- versus
(Z)-Stilbene to Chiral Fumarate upon Direct and Charge-Transfer-Band Excitation,
H. Saito, T. Mori, T. Wada, and Y. Inoue,
Org. Lett., 8, 1909 (2006).
126. Pressure and Temperature-Controlled Enantio-Differentiating [4+4]-Photo-Cyclodimerization of
2-Anthracene-carboxylate Mediated by Secondary Face- and Skeleton-Modified γ-Cyclodextrins,
C. Yang, A. Nakamura, G. Fukuhara, Y. Origane, T. Mori, T. Wada, and Y. Inoue,
J. Org. Chem., 71, 3126 (2006).
125. Absolute configuration determination of donor-acceptor [2.2]paracyclophanes by comparison of
theoretical and experimental vibrational circular dichroism spectra,
T. Furo, T. Mori, Y. Origane, T. Wada, H. Izumi, and Y. Inoue,
Chirality, 18, 205 (2006).
124. New Insights into the Geometry of Resorc[4]arenes: Solvent-Mediated Supramolecular Conformational
and Chiroptical Control,
C. Schiel, G. A. Hembury, V. V. Borovkov, M. Klaes, C. Agena, T. Wada, S. Grimme, Y. Inoue, and J.
Mattay,
J. Org. Chem. 71, 976 (2006).
123. Absolute Configuration of Chiral [2.2]Paracyclophanes with Intramolecular Charge-Transfer Interaction.
Failure of the Exciton Chirality Method and Use of the Sector Rule Applied to the Cotton Effect of the
CT Transition.
T. Furo, T.Mori, T.Wada, and Y.Inoue,
J. Am. Chem. Soc. 127, 8242 (2005).
122. Entropy-controlled supramolecular photochirogenesis: enantiodifferentiating Z-E photoisomerization of
cyclooctene included and sensitized by permethylated 6-O-benzoyl-β-cyclodextrin.
G.Fukuhara, T.Mori, T. Wada, and Y.Inoue,
Chem. Comm., 4199 (2005).
121. Peptide ribonucleic acids (PRNA): novel strategy for active control of DNA recognition by external factors.
T. Wada and Y. Inoue,
Proteins, Nucleic Acids, Enzyme, 50, 463 (2005).
120. Supramolecular photochirogenesis in sensitizing chiral nanopore: Enantiodifferentiating
photoisomerization of (Z)-cyclooctene included and sensitized by POST-1.
Y.Gao, T. Wada, K.Yang, K. Kim, and Y.Inoue,
Chirality, 17, 19 (2005).
119. Enantiodifferentiating [4+4] photocyclodimerization of 2-anthracenecarboxylate catalyzed by
6A,6X-diamino-6A,6X-dideoxy-β-cyclodextrins: Manipulation of product chirality by electrostatic
interaction, temperature and solvent in supramolecular photochirogenesis.
C.Yang, G.Fukuhara, A.Nakamura, Y.Origane, K.Fujita, T.Wada, and Y.Inoue,
J. Photochem. Photobio.,A:, 173, 375 (2005).
118. Diastereomeric Molecular Recognition and Binding Behavior of Bile Acids by
L/D-Tryptophan-Modified β-Cyclodextrins.
T.Wada, H.Wang, R.Cao, Y.Liu, and Y. Inoue,
J. Org. Chem., 70, 8703 (2005).

117. Mechanism of photoisomerization of optically pure trans-2,3-diphenylcyclopropane-1-carboxylic acid
derivatives.
J.Sivaguru, T.Wada, Y.Inoue, and V.Ramamurthy, V.
Photochem. Photobio. Sci., 4, 119 (2005).
116. Functionalization of PNA - novel strategy for active control of DNA recognition by external factors
using peptide ribonucleic acids (PRNA),
T. Wada and Y. Inoue,
Yuki Gosei Kagaku Kyokaishi 63, 63 (2005).
115. Supramolecular asymmetric photoreactions.
T.Wada and Y.Inoue,
Mol.Supramol.Photochem.11,341 (2004).
114. Synthesis of Peptide Ribonucleic Acid Consisting of D- and L-γ-Glutamic Acid as a Backbone Structure,
T. Wada, Y. Hashimoto, H. Sato, and Y. Inoue,
Nucleic Acids Res., 32, 27-28 (2004).
113. Diastereoselective [2 + 2] Photocycloaddition of Stilbene to Chiral Fumarate. Direct versus
Charge-Transfer Excitation,
H. Saito, T. Mori, T. Wada, and Y. Inoue,
J. Am. Chem. Soc., 126, 1900 (2004).
112. Enantiodifferentiating Photoaddition of Alcohols to 1,1-Diphenylpropene in Supercritical Carbon
Dioxide: Sudden Jump of Optical Yield at the Critical Density,
Y. Nishiyama, M. Kaneda, R. Saito, T. Mori, T. Wada, and Y. Inoue,
J. Am. Chem. Soc., 126, 6568 (2004).
111. A 5’-Amino-5’-deoxyribonucleoside Containing Nucleic Acid Model for External Reversible Control of Recognition Behavior
through anti-syn Orientational Switching of the Nucleobase Induced by Borate Esterification of the cis-2’,3’-Diol,
T .Wada, H. Sato, N. Minamimoto, and Y. Inoue,
Biopolym., 76, 15 (2004).
110. Active control of DNA recognition behavior of -peptide ribonucleic acids containing basic amino acid
residues by external factors,
T. Wada Y. Inoue,
Polym. Prep., 45, 447 (2004).
109. Pressure control of enantiodifferentiating polar addition of 1,1-diphenylpropene sensitized by chiral
Naphthalenecarboxylates,
M. Kaneda, Y. Nishiyama, S. Asaoka, T. Mori, T. Wada, and Y. Inoue,
Org. Biomol. Chem., 2, 1295 (2004).
108. Residue- and sequence-selective binding of nonaromatic dipeptides by bis(β-cyclodextrin) with a
functional tether,
Y. Liu, Y. Yang, Y. Song, H. Zhang, T. Wada, and Y. Inoue,
Chem. Bio. Chem., 5, 868 (2004).
107. Enhanced Diastereoselectivity via Confinement: Diastereoselective Photoisomerization of
2,3-Diphenyl-1-benzoylcyclopropane Derivatives within Zeolites,
J. Sivaguru, B. Raghavan. T. Wada, Y. Origane, Y. Inoue, and V. Ramamurthy,
J. Org. Chem., 69, 5528 (2004).
106. Enhanced Diastereoselectivity via Confinement: Photoisomerization of
2,3-Diphenylcyclopropane-1-carboxylic Acid Derivatives within Zeolites,
J. Sivaguru, B. Raghavan. T. Wada, Y. Origane, Y. Inoue, and V. Ramamurthy,
J. Org. Chem., 69, 6533 (2004).
105. Enantioselective [4+2]-cycloaddition reaction of a photochemically generated O-quinodimethane:
Mechanistic details, association studies, and pressure effects,
B. Grosch, C. Orlebar, M. Kaneda, T. Wada, Y. Inoue, and T. Bach,
Chem. -A Eur. J., 10, 2179 (2004).
104. Active control of DNA recognition behavior of α-peptide ribonucleic acids containing basic amino acid residues by
external factors,
H. Sato, T. Wada, and Y. Inoue,
J. Bioactive and Compatible Polym., 19, 65 (2004).

103. Pressure control of diastereodifferentiating [2 + 2] photocycloaddition of (E)-stilbene to chiral fumarate
upon direct and charge-transfer excitation,
H. Saito, T. Mori, T. Wada, and Y. Inoue,
Chem. Comm., 1652 (2004).
102. Remarkable differences in photo and thermal (acid-catalyzed) reactivities between ortho- and
para-acylcyclohexadienones as essential factors determining the overall efficiency of the photo-Fries
rearrangement,
T. Mori, M. Takamoto, H. Saito, T. Furo, T. Wada, and Y. Inoue,
Chem. Lett., 33, 256 (2004).
101. Isolation of cyclohexadienone intermediates in the photo-Fries rearrangement of 2,4-dimethylnaphth-1-yl
and 1,4-dimethylnaphth-2-yl 2,4,6-trimethylbenzoates,
Mori, Tadashi; Takamoto, Makoto; Saito, Hideaki; Furo, Takahiro; Wada, Takehiko; Inoue, Yoshihisa,
Chem. Lett., 33, 254 (2004).
100. Bovine Serum Albumin-Mediated Enantiodifferentiating Photocyclodimerization of
2-Anthracenecarboxylate,
T. Wada, M. Nishijima, T. Fujisawa, N. Sugahara, T. Mori, A. Nakamura, Y. Inoue,
J. Am. Chem. Soc. 125, 7492 (2003).
99. Solid-Phase Synthesis of Peptide Ribonucleic Acids (PRNA),
T. Wada, H. Sato, Y. Hashimoto, and Y. Inoue,
Tetrahedron, 59, 7871 (2003).
98. Supra-Molecular Self-Assemblies of β-Cyclodextrins with Aromatic Tethers: Factors Governing the
Helical Columnar versus Linear Channel Super-Structures,
Y. Liu, Z. Fan, H. Zhang, Y. Yang, F. Ding, T. Wada, and Y. Inoue,
J. Org. Chem. 68, 8345 (2003).
97. A Novel Strategy for Reversible Control of Conformation and DNA/RNA Recognition of Peptide
Ribonucleic Acid (PRNA) by External Factors,
T. Wada, H. Sato, and Y. Inoue,
Nucleic Acids Research, Suppl., 3, 213(2003).
96. Pressure control of enantiodifferentiating photoisomerization of cyclooctenes sensitized by chiral
benzenepolycarboxylates. The origin of discontinuous pressure dependence of the optical yield,
M. Kaneda, A. Nakamura, S. Asaoka, H. Ikeda, T. Wada, and Y. Inoue,
Org. Biomol. Chem., 1, 4435 (2003).
95. Acid-controlled photoreactions of aryl alkanoates: competition of trans-esterification,
decarboxylation, Fries-rearrangement and/or transposition,
T. Mori, M. Takamoto, T. Wada, and Y. Inoue,
Photochem. Photobio. Sci, 2, 1187 (2003).
94. Selective Binding of Steroids by 2,2'-Biquinoline-4,4'-dicarboxamide-Bridged Bis(β-cyclodextrin):
Fluorescence Enhancement by Guest Inclusion,
Y. Liu, Y. Song, H. Wang, H. Zhang, T. Wada, Y. Inoue,
J. Org. Chem. 68, 3687 (2003).
93. Detail CD spectra analysis in view of angular momentum using chiral Eu(III) complexes,
Y. Hasegawa, T. Tomita, Y. Wada, T. Wada, Y. Inoue, S. Yanagida,
Kidorui, 42, 132 (2003).
92. Synthesis of Phosphoryl-Tethered β-Cyclodextrins and Their Molecular and Chiral Recognition
Thermodynamics,
Liu, Yu; Li, Li; Li, Xiao-Yun; Zhang, Heng-Yi; Wada, Takehiko; Inoue, Yoshihisa,
J. Org. Chem., 68, 3646 (2003).
91. First synthesis, isolation and characterization of enantiomerically pure and inherently chiral resorc[4]arenes
by lewis acid cyclization of a resorcinol monoalkyl ether,
M. Klaes, C. Agena, M. Kohler, M. Inoue, T. Wada, Y. Inoue, J. Mattay,
Eur. J. Org. Chem., 1404 (2003).

90. Microenvironmental Polarity Control of Electron-Transfer Photochirogenesis. Enantiodifferentiating
Polar Addition of 1,1-Diphenyl-1-alkenes Photosensitized by Saccharide Naphthalenecarboxylates,
S. Asaoka, T. Wada, and Y. Inoue,
J. Am. Chem. Soc., 125, 3008 (2003).
89. DNA Recognition Control of γ-PRNA and Mismatched Base Effects upon Complex Stability,
H. Sato, Y. Hashimoto, M. Kikkawa, T. Wada, and Y. Inoue,
Nucleic Acids Res. Supple., 2, 159 (2002).
88. Discontinuous pressure effect upon enantiodifferentiating photosensitized isomerization of cyclooctene,
M. Kaneda, S. Asaoka, H. Ikeda, T. Mori, T. Wada, and Y. Inoue,
Chem. Comm., 1272 (2002).
87. Highly diastereoselective photoaddition of methanol to limonene,
D. S. Kim, S. C. Shim, T. Wada and Y. Inoue,
Tetrahedron Lett., 42, 4341 (2001).
86. First asymmetric photosensitization in supercritical fluid. Exceptionally high pressure/density
dependence of optical yield in photosensitized enantiodifferentiating isomerization of cyclooctene,
R. Saito, M. Kaneda, T. Wada, A. Katoh, and Y. Inoue,
Chem. Lett., 860 (2002).
85. Diastereoselectivity Control in Photosensitized Addition of Methanol to (R)-(+)-Limonene,
S.Shim, K. Chul, S. Dong, D. Yoo, T. Wada, and Y. Inoue,
J. Org. Chem., 67, 5718 (2002).
84. The first circular dichroism observation for organic radical cations: chiroptical properties of
neomenthyloxy- and isobornyloxyanisole radicalcations,
T. Mori, J. Shinkuma, M. Sato, H. Saito, T. Wada, and Y. Inoue,
Enantiomer, 7, 115 (2002).
83. Unique Dual Fluorescence of Sterically Congested HexaalkylBenzenehexacarboxylates: Mechanism and
Application to Viscosity Probing,
Y. Inoue, P. Jiang, E. Tsukada, T. Wada, H. Shimizu, A. Tai, and M. Ishikawa,
J. Am. Chem. Soc., 124, 6942 (2002).
82. Conformation and Recognition Control of Peptide Ribonucleic Acid Containing Pyrimidine/Purine
Mixed sequence,
T. Wada, H. Sato, and Y. Inoue,
Nucleic Acids Res. Supple., 1, 229 (2001).
81. External electric field effects on exciplex formation of 1,1-diphenylpropene with chiral
1,4-naphthalenedicarboxylate in PMMA polymer films,
Y. Takehara, Y. Ohta, S. Shiraishi, S. Asaoka, T. Wada, and Y. Inoue,
J. Photochem. Photobiol., A: Chem., 145, 53(2001).
80. Photoinduced Electron Transfer Oxidation of Olefins with Molecular Oxygen Sensitized by
Tetrasubstituted Dimethoxybenzenes: A Non-Singlet-Oxygen Mechanism,
T. Mori, M. Takamoto, T. Wada, Y. Inoue,
Helv. Chim. Acta, 84, 2693 (2001).
79. Cooperative Molecular Recognition by Novel Calix[4]arene-Tethered β-Cyclodextrin and
Calix[4]arene-Bridged Bis(β-cyclodextrin),
Y. Liu, Y. Li, T. Wada, and Y. Inoue,
J. Org. Chem., 66, 7209 (2001).
78. First Photosensitized Enantiodifferentiating Isomerization by Optically Active Sensitizer Immobilized in
Zeolite Supercages,
T. Wada, M. Shikimi, G. Lem, N. J. Turro, and Y. Inoue,
Chem. Commun, 1864 (2001).
77. Extensively Interlocked 2-D Supramolecular Architecture of Self-Adhesive Double-Tailed
1,3-planar-2,4-upright-Calix[4]arene,
Y. Liu, B.-T. Zhao, B. Li, T. Wada, and Y. Inoue,
Chem. Lett., 652 (2001).

76. Complexation Thermodynamics of Light Lanthanoid Nitrates with Novel p-tert-Butylcalix[4]arene Schiff
Base in Acetonitrile: An Enhanced Eu 3+ Selectivity by Side-Arm Ligation,
Y. Liu, B. Li, T. Wada, and Y. Inoue,
J. Chem. Soc., Perkin Trans. 2, 1219 (2001).
75. Cooperative Multipoint Recognition of Organic Dyes by Bis(β-cyclodextrin)s with
2,2’-Bipyridine-4,4’-dicarboxy Tethers,
Y. Liu, Y. Chen, X. D. Guan, T. Wada, and Y. Inoue,
Chem. Eur. J, 7, 2528 (2001).
74. Molecular Recognition of Dyes by Organoselenium-Bridged Bis(β-cyclodextrin)s,
Y. Liu, Y. Li, T. Wada, and Y. Inoue,
J. Org. Chem., 66, 225 (2001).
73. Complexation Thermodynamics of p-tert-Butylcalix[4]arene Derivatives with Light Lanthanoid Nitrates
in Acetonitrile,
Y. Liu, B. Li, T. Wada, and Y. Inoue,
Supramol. Chem., 12, 529 (2001).
72. Fluorometric Studies on Inclusion Complexation of L/D-Tryptophan by β-Cyclodextrin
6-O-Pyridinecarboxylates,
Y. Liu, B. Li, T. Wada, and Y. Inoue,
Bioorg. Chem., 29, 19 (2001).
71. Vital role of entropy in photochirogenesis,
Y. Inoue, N. Sugahara, and T. Wada,
Pure Appl. Chem., 73, 475 (2001).
70. Circular Dichroism Spectral Studies on Molecular and Chiral Recognition of Aliphatic Alcohols by
6-Modified β-cyclodextrins,
Y. Liu, B. Li, T. Wada, and Y. Inoue,
Tetrahedron, 57, 7153 (2001).
69. Unique Fluorescence Behavior of Rhodamine B upon Inclusion Complexation with Novel
Bis(β-cyclodextrin-6-yl) 2,2'-Bipyridine-4,4'-dicarboxylate,
Y. Liu, Y. Chen, X. D. Guan, T. Wada, and Y. Inoue,
Org. Lett., 3, 1657 (2001).
68. Photoinduced Electron Transfer Oxidation of α-Methylstyrene with Molecular Oxygen sensitized by
Dimethoxybenzenes,
T. Mori, T. Wada, and Y. Inoue,
Tetrahedron Lett., 42, 2505 (2001).
67. Enantiodifferentiating Z-E photoisomerization of cyclooctene Sensitized by DNA and RNA,
T. Wada, N. Sugahara, M. Kawano, and Y. Inoue,
Nucleic Acids Res., 44, 115 (2000).
66. Inclusion Complexation Thermodynamics of Aliphatic Alcohols by Organoselenium Modified
β-Cyclodextrins,
Y. Liu, B. Li, T. Wada, and Y. Inoue,
Inclusion Phenom. Mol. Recognition. Chem. 36, 311 (2000).
65. Photochirogenesis: Multidimensional control of asymmetric photochemistry,
Y. Inoue, S. Asaoka, H. Sato, and T. Wada,
Chem. Commun, 251 (2000).
64. First asymmetric photochemistry with nucleosides and DNA: enantiodifferentiating Z-E
photoisomerization of cyclooctene,
T. Wada, N. Sugahara, M. Kawano, and Y. Inoue,
Chem. Lett., 1174 (2000).
63. Synthesis and conformation control of peptide ribonucleic acid containing
5'-amino-5'-deoxyribopurinenucleosides,
T. Wada, H. Sato, N. Minamimoto, and Y. Inoue,
Nucleic Acids Res., 44, 211 (2000).

62. Supramolecular Photochirogenesis. 2. Enantiodifferentiating Photoisomerization of Cyclooctene Included
and Sensitized by 6-O-Modified Cyclodextrins,
Y. Inoue, N. Sugahara, K. Yamamoto, and T. Wada,
J. Org. Chem., 65, 8041 (2000).
61. Synthesis of Novel Double-Armed Benzo-15-crown-5 Lariats and Their Complexation Thermodynamics
with Light Lanthanoid Nitrates in Acetonitrile,
Y. Liu, T. Wada, and Y. Inoue,
J. Org. Chem., 65, 7105 (2000).
60. Peptide Ribonucleic Acids (PRNA) 2. A Novel Strategy for Active Control of DNA Recognition through
Borate Ester Formation,
T. Wada, N. Minamimoto, Y. Inaki, and Y. Inoue,
J. Am. Chem. Soc., 122, 6900 (2000).
59. Perfect Switching of Photoreactivity by Acid: Photochemical Decarboxylation versus Transesterification of
Mesityl Cyclohexanecarboxylate,
T. Mori, T. Wada, and Y. Inoue,
Org. Lett., 2, 3401 (2000).
58. Molecular recognition of fluorescent dyes with novel triethylenetetraamine-tethered bis(β-cyclodextrin)
and its copper(II) complex: enhanced binding and selectivity by tether ligation,
Y. Liu, C. You, T. Wada, and Y. Inoue,
Tetrahedron Lett., 41, 6869 (2000).
57. Molecular Interpenetration within the Columnar Structure of Crystalline Anilino-β-cyclodextrin,
Y. Liu, C. You, M. Zhang, T. Wada, and Y. Inoue,
Org. Lett., 2, 2761 (2000).
56. Anilino- and m-Toluidino-β-Cyclodextrins: Structure and Conformational Analyses and Molecular Recognition of
Aliphatic Alcohols,
Y. Liu, A. Nakamura, T. Wada, and Y. Inoue,
Supramol. Chem., 12, 299 (2000).
55. Molecular Design of Crown Ethers. 19. Synthesis of Novel Disulfide- and Diselenide-Bridged
Bis(benzo-12-crown-4)s and Their Ag + -Selective Electrode Properties,
Y. Liu, C. You, M. Zhang, T. Wada, and Y. Inoue
J. Org. Chem., 65, 2870 (2000).
54. Effect of Host Substituent upon Inclusion Complexation of Aliphatic Alcohols with
Organoseleno-β-cyclodextrins,
Y. Liu, C. You, M. Zhang, T. Wada, and Y. Inoue,
J. Chem. Res (S), 90 (2000).
53. Enantiodifferentiating photocyclodimerization of cyclohexene sensitized by chiral benzenecarboxylates,
S. Asaoka, H. Horiguchi, T. Wada, and Y. Inoue,
J. Chem. Soc., Perkin Trans. 2, 737 (2000).
52. Molecular Recognition of Aliphatic Alcohols and Carboxylic Acid by Chromophoric Cyclodextrins,
Y. Liu, C. You, M. Zhang, T. Wada, and Y. Inoue,
Supramol. Chem., 12, 243 (2000).
51. Enantiodifferentiating photocyclo-dimerization of cyclohexa-1,3-diene sensitized by chiral
arenecarboxylates,
S. Asaoka, M. Ooi, P. Jiang, T. Wada, and Y. Inoue,
J. Chem. Soc., Perkin Trans. 2, 77 (2000).
50. Novel o-phenylenediseleno bridged bis(β-cyclodextrin)s complexes with platinum(IV) and palladium(II)
ions,
Y. Liu, B. Li, T. Wada, and Y. Inoue,
Supramol. Chem., 10, 279 (1999).
49. Inclusion Complexation by Organoselenium-Bridged Bis(β-cyclodextrin)s and Their Platinum(IV)
Complexes,
Y. Liu, B. Li, C-C. You, Y. Chen, T. Wada, and Y. Inoue,
J. Org. Chem., 64, 7781 (1999).

48. Enantioselective recognition of aliphatic amino acids by organoselenium-modified β-cyclodextrins,
Y. Liu, B. Li, T. Wada, and Y. Inoue,
Supramol. Chem., 10, 173 (1999).
47. Size, Shape, and Chiral Recognition of Aliphatic Alcohols by Organoselenium-Modified Cyclodextrins,
Y. Liu, C. You, T. Wada, and Y. Inoue,
J. Org. Chem., 64, 3630 (1999).
46. Entropy-Controlled Asymmetric Photochemistry: Switching of Product Chirality by Solvent,
Y. Inoue, H. Ikeda, M. Kaneda, , T. Sumimura, and T. Wada,
J. Am. Chem. Soc., 122, 406 (2000).
45. Enantiodifferentiating Anti-Markovnikov Photoaddition of Alcohols to 1,1-Diphenylalkenes Sensitized
by Chiral Naphthalenecarboxylates,
S. Asaoka, T. Kitazawa, T. Wada, and Y. Inoue,
J. Am. Chem. Soc., 121, 8486 (1999).
44. Molecular Recognition and Enantioselectivity of Aliphatic Alcohols by L-Tryptophan-Modified
β-Cyclodextrin,
Y. Liu, B. Li, B. Han, T. Wada, and Y. Inoue,
J. Org. Chem., 64, 1487 (1999).
43. Recognition Control of the Nucleic Acid Model through Conformational Switching of Nucleobase
Induced by Borate Ester Formation of cis-2',3'-Diol,
T. Wada, N. Minamimoto, H. Satoh, and Y. Inoue,
Nucleic Acids Res., 42, 145 (1999).
42. Complexation Thermodynamics of Selenacrown Ether: Origin of High Silver(I) Selectivity of
1,5,14,18-Tetraselena-8, 11,21,24-tetraoxycyclohexacosane,
Y. Liu, S. P. Dong, T. Wada, and Y. Inoue,
J. Chem. Res (S), 284 (1999).
41. Molecular Recognition and enantioselectivity of Aliphatic Alcohols by L-Tryptophan-Modified
β-Cyclodextrins,
Y. Liu, B. Han, B. Li, S. Sun, T. Wada, and Y. Inoue,
J. Org. Chem., 64, 1487 (1999).
40. Circular dichroism studies of inclusion complexation of aliphatic alcohols by organoselenium modified
β-cyclodextrins,
Y. Liu, B. Li, B. Han, T. Wada, and Y. Inoue,
J. Chem. Soc., Perkin Trans. 2 , 563 (1999).
39. Inclusion Complexation of Modified β-Cyclodextrins with Amino Acids: Enhanced Enantioselectivity
for L/D-Leucine,
Y. Liu, Y. Zhang, A. Qi, R. Chen, K. Yamamoto, T. Wada, and Y. Inoue,
J. Org. Chem., 63, 10085 (1998).
38. Syn/Anti Orientational Control of Pyrimidine Nucleosides and Apply to Regulation of Recognition,
T. Wada, N. Minamimoto, Y. Inaki, and Y. Inoue,
Nucleic Acids Res. 39, 29 (1998).
37. Isopoly-L-ornithine derivatives of the thymine and thymidine,
T. Wada, N. Tohnai, K. Miyabayashi, and Y. Inaki,
Nucleosides Nucleotides, 17, 339 (1998).
36. Synthesis of Modified Cyclodextrins and Their Inclusion Complexation Thermodynamics with
L-Tryptophan and Some Naphthalene Derivatives,
Y. Liu, B. Han, B. Li, Y. Zhang, P. Zhao, Y. Chen, T. Wada, and Y. Inoue,
J. Org. Chem., 63, 1444 (1998).
35. Conformational and Orientational Switching of Uridine Derivatives by Borates,
T. Wada, N. Minamimoto, Y. Inaki, and Y. Inoue,
Chem Lett, 1025 (1998).
34. Inclusion Complexation of (Cyclo)alkanes and (Cyclo)alkanols with 6-O-Moddified Cyclodextrins,
Y. Inoue, K. Yamamoto, X. Gao, Z.Hou, L.Tong, S.Jiang, H. Wu, and T. Wada,
J. Chem. Soc., Perkin Trans. 2, 1807 (1998).

33. Specific Interaction between 5'-Aminonucleosides and Borates and Influence of Borates on Nucleoside
Conformations,
T. Wada, N. Minamimoto, Y. Inaki, and Y. Inoue,
Nucleic Acids Res., 37, 9 (1997).
32. Molecular Recognition in Chemistry and Biology as Viewed from Enthalpy-Entropy Compensation
Effect,
Y. Inoue and T. Wada,
Adv. Supramol. Chem., 4, 55 (1997).
31. Pressure and Temperature Control of Product Chirality in Asymmetric Photochemistry,
Enantiodifferntiating Photoisomerization of Cyclooctene Sensitized by Chiral Benzenepolycarboxylates,
Y. Inoue, E. Matsushima, and T. Wada,
J. Am. Chem. Soc., 120, 10687 (1998).
30. Polyethyleneimine Derivatives as Nucleic Acid Model and Interaction with DNA,
T. Wada and Y. Inaki,
New Macromol. Archit. Funct., 2, 79 (1997).
29. Immobilization of cytidine and guanosine on silica gel and specific separation of oligonucleotides,
T. Wada, Y. Inaki, H.Kawano, T.Watanabe, K.Takemoto, and Y. Inoue,
Supramol. Chem., in Press.
28. Inclusion Complexation of Modified β-Cyclodextrins with Amino Acids: Enhanced Enantioselectivity
for L/D-Leucine,
Y. Inoue, K. Yamamoto, X. Gao, Z. Hou, L. Tong, S. Jiang, H. Wu, and T. Wada,
J. Org. Chem., 62, 1826 (1997).
27. Synthesis and Properties of Polyamide Derivatives Containing Nucleosides,
T. Wada, N. Minamimoto, Y. Inaki, and Y. Inoue,
Nucleic Acids Res., 24, 97 (1996).
26. Synthesis of Hyaluronan Conjugated with Nucleic Acid Bases,
T. Wada, S. Chirachanchai, N. Izawa, Y. Inaki, and K. Takemoto,
Industrial Biotechnol. Polym., 121 (1996).
25. Photodimerizations and crystal structures of thymine derivatives having a long alkyl chain connected
with a carbamate bond,
T. Wada, T. Sugiki, N. Tohnai, and Y. Inaki
Bull. Chem. Soc. Jap., 69, 1777 (1996).
24. Synthesis of Polymers Containing Pyrimidine Base as Chemical Amplified Resist,
T. Sugiki, T. Wada, and Y. Inaki,
J. Photopolym. Sci. Technol., 8, 123 (1995).
23. Synthesis of Nucleic Acid Analogs Made up of poly-w-Amino Acids as a Main Chains,
T. Wada, N. Minamimoto, K. Okada, K. Miyabayashi, Y. Inaki, and M. Miyata,
Nucleic Acids Res., 23, 189 (1995).
22. Transport Performance of Nucleosides through Nucleic Acid Bases Conjugated Hyaluronic Acid,
T. Wada, S. Chirachanchai, Y. Inaki, and K. Takemoto,
Chem Lett., 121 (1995).
21. Synthesis and properties of water soluble poly-L- and -D-lysine derivatives containing nucleic acid bases,
T. Wada, M. Nakamori, E. Mochizuki, and Y. Inaki,
Nucleic Acids Res., 22, 135 (1994).
20. Synthesis of Sulfonated Hyaluronan Derivatives Containing Nucleic Acid Bases,
T. Wada, S. Chirachanchai, N. Izawa, Y. Inaki, and K. Takemoto,
Chem Lett., 2027 (1994).
19. Synthesis and Properties of Hyaluronic Acid Conjugated Nucleic Acid Analogs:
Synthesis of Deacetylhyaluronan and Introduction of Nucleic Acid Base,
T. Wada, S. Chirachanchai, N. Izawa, Y. Inaki, and K. Takemoto,
J. Bioactive Comp. Polym., 9, 429 (1994).

18. Photodimerization and Crystal Structure of Long Alkyl Thymine Derivatives,
T. Wada, N. Tohnai, T. Sugiki, E. Mochizuki, and Y. Inaki,
J. Photopolym. Sci. Technol., 7, 91 (1994).
17. High-performance liquid chromatographic separation of oligonucleotides using deoxyadenosine
immobilized silica gels for the stationary phase. Effect of the deoxyadenosine ligand concentration,
T. Wada, K. Matsukawa, H. Wang, E. Mochizuki, K. Takemoto, and Y. Inaki,
Jap. Bunseki Kagaku, 42, 825 (1993).
16. Synthesis and properties of oligolysine and oligoglutamic acid derivatives containing nucleosides,
T. Wada, K. Okada, M. Nakamori, E. Mochizuki, and Y. Inaki,
Nucleic Acids Res., 21, 79 (1993).
15. Synthesis and interaction studies of water soluble nucleic acid analogs containing serine as a spacer,
T. Wada, N. Masumi, E. Mochizuki, Y. Inaki, and K. Takemoto,
Nucleic Acids Res., 20, 115 (1992).
14. Immobilization of nucleoside on silica gel and specific separation of oligonucleotides,
T. Wada, Y. Inaki, K. Matsukawa, H. Kawano, W. Hong, E. Mochizuki, and K. Takemoto,
Nucleic Acids Res., 20, 29 (1992).
13. Photodimerization of Thymine Derivatives in Ionomer Matrix,
T. Wada, E. Mochizuki, K. Masuda, and Y. Inaki,
J. Photopolym. Sci. Technol., 6, 131 (1993).
12. High-performance liquid chromatographic separation of oligonucleotides using deoxyadenosine
immobilized on silica gel as stationary phase,
Y. Inaki, K. Matsukawa, H. Wang, E. Mochizuki, T. Wada, and K. Takemoto,
Jap. Bunseki Kagaku, 42, 99 (1993).
11. Preparation of PVA membrane containing nucleic acid analogs and studies on separation of nucleosides and dinucleotides
using this membrane,
T. Wada, S. Chirachanchai, Y. Inaki, and K. Takemoto,
Mol. Cryst. Liq. Cryst. Sci. Technol., Sect. A, 219, 169 (1992).
10. Synthesis and interaction of water soluble nucleic acid analogs,
K. Takemoto, T. Wada, E. Mochizuki, and Y. Inaki,
Biotechnol Polym.,31 (1991).
9. Synthesis and interaction studies of oligo and polyamino acids derivatives containing nucleosides,
T. Wada, E. Mochizuki, Y. Inaki, and K. Takemoto,
Nucleic Acids Res., 19, 19 (1991).
8. Synthesis and interaction studies on water soluble nucleic acid analogs: poly-L-lysine derivatives containing thymine
and hypoxanthine,
T. Wada, Y. Inaki, and K. Takemoto,
J. Bioactive Comp. Polym., 7, 25 (1992).
7. Nucleic acid analogs : Their specific interaction and applicability,
T. Wada, E. Mochizuki, Y. Inaki, and K. Takemoto,
Biomimetic Polymers, 253 (1990).
6. Synthesis and interaction of water-soluble nucleic acid analogs,
K. Takemoto, T. Wada, E. Mochizuki, and Y. Inaki,
Polym. Mater. Sci. Eng., 62, 558 (1990).
5. Water soluble synthetic nucleic acid analogs-polyethyleneimine derivatives containing nucleic acid
bases-conformation and interaction with nucleic acids,
T. Wada, E. Mochizuki, Y. Inaki, and K. Takemoto,
Nucleic Acids Res., 18, 113 (1990).
4. Synthesis and interaction studies on water soluble nucleic acid analogs : Polyethyleneimine derivatives
containing Uracil and 5-fluorouracil,
T. Wada, Y. Inaki, and K. Takemoto,
J. Bioactive Comp. Polym., 4, 25 (1989).

3. Synthesis and interaction studies on water soluble nucleic acid analogs: Polyethyleneimine derivatives
containing thymine and adenine,
T. Wada, Y. Inaki, and K. Takemoto,
Polymer J., 20, 1059 (1988).
2. Synthesis and interaction studies on water soluble nucleic acid analogs: Polyethyleneimine derivatives
containing cytosine and hypoxanthine,
T. Wada, Y. Inaki, and K. Takemoto,
Polymer J., 21, 11 (1989).
1. Synthesis and properties of polyamino acid derivatives containing nucleic acid bases and nucleosides.
T. Wada, E. Mochizuki, Y. Inaki, and K. Takemoto,
Peptide Chemistry 1987, 41 (1988).
(2) Reviews
1. Artificial Nucleic Acids, Takehiko Wada, Polymer,42, 933(1993).
2. New trends on DNA studies using photochemistry, T. Wada and Y. Inoue, Photochemistry, 23, 56 (1996).
3. Asymmetric Photoreactions using Nucleosides and DNA photosensitizers, T. Wada and Y. Inoue, Industry
and Technology, 49, 56 (1997).
4. New trends on DNA studies using photochemistry, T. Wada and Y. Inoue, Chemistry, 53, 68-69 (1998).
5. Studies on enantiodifferentiating photosensitization using DNA as chiral sensitizer and/or reaction field
T. Wada, Y. Inoue, Asahi Garasu Zaidan Josei Kenkyu Seika Hokoku (1999).
6. Asymmetric Photoreaction under High Pressure -Pressure Control of Product Chirality-,
M. Kaneda, T. Wada, and Y. Inoue,
The Review of High Pressure Science and Technology, 11, 227 (2001).
7 Functionalization of PNA - a novel strategy for active control of DNA recognition by external factors using
peptide ribonucleic acids (PRNA). Wada, Takehiko, Biomaterials, 21, 278 (2003).
7 Artificial Nucleic acids - a novel strategy for active control of DNA recognition by external factors using
peptide ribonucleic acids (PRNA). Wada, Takehiko, J. Synt. Org. Chem. Jap., 63, 63 (2005).
7 A Novel Strategy for Active Control of DNA Recognition by External Stimulates - Peptide Ribonucleic Acids
(PRNA) -, Wada, Takehiko, Yoshihisa Inoue, Protein, Nucleic Acid and Enzyme, 50, 463 (2005).
(3) Books
1. “Artificial Nucleic Acids” -Synthesis, Functions, and Applications-, Y. Inaki, E. Mochizuki, and T. Wada,
IPC, (1992)
2. Nucleic Acid Analogs (Syntheses and Properties),
T. Wada, Y. Inaki, and K. Takemoto,
The Polymeric Materials Encyclopedia: Synthesis, Properties and Applications,
J. C. Salamone and M. Lowell Eds., CRC Press Inc., Boca Raton, FL, USA, 94-108 (1996).
3. “Molecular Recognitions”, Y. Inoue and T. Wada, Sankyo Publications, Tokyo ( 1997)
4. “Biopolymers”, T. Wada, Kodansha Scientific, Tokyo (1999).
5. Supramolecular Asymmetric Photoreactions, T. Wada and Y. Inoue,
Organic Molecular Photochemistry; Ramamurthy, V.; Inoue, Y. Ed.; Marcel Dekker: New York, in press.