Intravitreal corticosteroid MWS 2012 Han.ppt (Read-Only)
Intravitreal corticosteroid MWS 2012 Han.ppt (Read-Only)
Intravitreal corticosteroid MWS 2012 Han.ppt (Read-Only)
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12/12/11<br />
Case presentation<br />
Ø 54 year old man with non-ischemic<br />
CRVO OD, negative systemic workup<br />
Ø s/p Trental 400 mg; VA worsened<br />
from 20/25 to 20/100 (8/07-11/07)<br />
Ø 11/07: VA 20/100, 4+CME, phakic<br />
5<br />
Ø Elected participation in the SCORE<br />
trial on IVTA for CRVO 6<br />
7/31/08, 4 months after 2 nd IVTA injection (SCORE trial), VA 20/60, IOP 17, lens clear<br />
7<br />
Mechanisms of corcosteroid <br />
acon <br />
Ø Enhances the barrier function of<br />
vascular tight junctions<br />
Ø Prevents leukocyte migration<br />
Ø Inhibits proinflammatory cytokine<br />
synthesis, and VEGF expression<br />
Ø DME and RVO-ME associated ME are<br />
mediated by VEGF induced loss of<br />
tight junctions and inflammation<br />
Kiernan DF, Mieler WF. Expert Opin Pharmacother 2009;10:2511-2525<br />
Leopold IH. In: Surgical Pharmacology of the Eye. New York, NY: Raven<br />
Press; 1985:83-133.<br />
2
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