CARDIAC CATH LAB - Mount Sinai Hospital

RESEARCH AND CLINICAL TRIALS
Top Ten Major Publications: Mount Sinai Cardiac Cath Lab
1. Creatine kinase-MB elevation after coronary intervention correlates with diffuse atherosclerosis
and low-to-medium level elevation has a benign clinical course: Implication for early discharge
after coronary intervention. Kini A, Marmur J, Kini S, Dangas G, Wallenstein S, Cocke T, Brown E,
Ambrose J, Sharma S. J Am Coll Cardiol. 34:663, 1999.
Clinical Implications: This observational study was the first report in the literature to document
that minor post-procedure enzyme elevation is common after otherwise successful PCI and not
associated with any higher mortality at 12 to 15 months follow-up. We also established by careful
follow-up that patients with elevated CK-MB but declining value can safely be discharged home
without any untoward events.
2. Plaque neovascularization is increased in ruptured atherosclerotic lesions of the human aorta:
Implications for plaque vulnerability. Moreno P, Purushothaman K, Fuster V, Echeverri D,
Truszczynska H, Sharma S, O’Connor William. Circulation 110:2032, 2004.
Clinical Implications: We are the pioneers in making the observation that one of the
mechanisms of plaque rupture is mediated by new vessel formation in the adventitia and is
exaggerated in diabetic patients and in lesions with high lipid contents.
3. A simplified approach to bifurcation lesions in medium-to-large size vessels: Simultaneous
kissing stents (SKS) technique. Am J Cardiol 94: 913, 2004. Also SKS-DES in large bifurcation
lesions. Sharma S, Ahsan C, Lee J, Kim M, Fisher E, Steinheimer A, Kini A. Cathet Cardiovasc
Interv 65:10, 2005.
Clinical Implications: There are various techniques for PCI of large bifurcation coronary lesions
but none of them is perfect. We invented a simplified bifurcation technique of placing two
stents side-by-side with excellent short-term outcomes and lower restenosis (