09.11.2014 Views

Disseminated histoplasmosis mimicking miliary tuberculosis: a case ...

Disseminated histoplasmosis mimicking miliary tuberculosis: a case ...

Disseminated histoplasmosis mimicking miliary tuberculosis: a case ...

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

immunoperoxidase techniques on tissue sec- REFEWENCES<br />

tions." Allhough isolation of the fungus was not<br />

I. Pa~son RJ, Zarafonctis CJD. Hjstnplasmusis inMan:<br />

carried out in this <strong>case</strong>, a diagnosis of disscmi- reporl of scven cascs and a review or xventy-one<br />

nated <strong>histoplasmosis</strong> can be made with ceriainty <strong>case</strong>s. Arch Int Med 1945: 75: 1.<br />

because of the characteristic yeasr cells found in 2. Salhapatayavongs B. Batteipr BE. Wheat J, Slama<br />

tissue sections. In histological sections, other 'W, Wass JL. Clinical and labrxatnry fenlures of<br />

infections that need to be distinguished from disseminated <strong>histoplasmosis</strong> during two large urban<br />

<strong>histoplasmosis</strong> are <strong>tuberculosis</strong>, torulopsis, outbreaks. Medicinc (Baltimore) 1983; 62: 263-<br />

70.<br />

leishmaniasis. candidiasis and crypt~coccosis.~~~<br />

Goodwin et crl.klassified histopla.;mosis by<br />

considering the clinical and pathological features.<br />

The ~ntermediate duration of illness,<br />

preserice of' weighk loss, hepatosplenornegaly<br />

and focal destructive lesions, especially in the<br />

adrenal glands, place our patienl into the subacute<br />

disseminated form according to Goodwin's<br />

classification.<br />

Because tuberculos~s is cornmon In Malaysia,<br />

il is invariably thc first differential diagnosis in<br />

a <strong>case</strong> of this naturc. However. whel-le\~er acid<br />

fast bacilli cannot be deinonstratcd or isolated, a<br />

diagnosis of histoplasrnosis should be considered.<br />

Steroids should not be giver] in any<br />

granulomatous disease unless <strong>histoplasmosis</strong> had<br />

been exclrided, as it has been reported Lhal this<br />

frequently results in a fatal o~tcorne.~"<br />

'l'his patient had very severe adrenal gland<br />

involve~nent. Antemortern findings suggestive<br />

of adrcnal insufficiency include a marginally<br />

IOW blood pressurc and serum sodiuln level.<br />

Goodwin et al.' in nn exzensive study reported<br />

adrenal invtllvement at autopsy in 82% of all<br />

forms of clissernina~cd <strong>histoplasmosis</strong>.<br />

3. Goodwin RA, Shapiro JL, Thur~nan GH, Thunnan<br />

SS. Dcs Prez RM. Disscminalcd <strong>histoplasmosis</strong>:<br />

clinica1 and pathologic correlatiuna. Medicine<br />

(Baltimore) 1980; 59: 1-33.<br />

4. Juhnsron AW. Pustlcthwaite R, Ewcn SWB er al.<br />

t)isse~ninated hisroplasmtsis. J Inf 1984: 9. 79-82.<br />

5. ChinTH, McGarry T, Coopers eral. Dis~eminatcd<br />

histoplas~nosis it] the acquired immunodcficiency<br />

aqndrornc. Arch Int Mcd 1987; 147: 1181-4.<br />

6. Wheat J, French MLV, Kohlcr RH, Zimmennan<br />

SE, Smith WR, Nortun JA, Eilzen IIE. Smirh CD,<br />

Slaina TG. The diagthostic laboratory tests for<br />

hihtoplasmosis. A~~alysis of expcrier~ce m a large<br />

urban outbreak. Ann Int Med 1982; 97. h80-5.<br />

7. Wheat LJ, Kohlcr RB, Tewan RP. Diagnos~s of<br />

disseminated histnplasmos~s by detection of<br />

Histoplasma capapsulutum antigen in ser111n and urlnt.<br />

specitnens. N Engl J Mcd 1986; 3 14: 83-8.<br />

8. Klalt EC, Covgrove M.Mcyer PR. Rapid diagnosis<br />

of disseminated h~sluplasmusis in tissues. Arch<br />

Pathol Lab Med 1986; 110: l 173-5.<br />

9. Binford CH, Connor UH. Pathology uf Troplcal<br />

and errraurd~~~ary Discascs, Wasl~itrgton DC, Armed<br />

Forces Institute of Pathology, 1976 vol 2. pp 578-<br />

813.<br />

10. Taylor CD. Fanning E.4, Fcrgusorl JP cr 01. Dis-<br />

aeminnted h~stopla\mnsis in a nonetldernlr: area.<br />

Can Med Assoc 1 1985. 133( 15): 763-5.

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!