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IDH muta5ons were infrequent in chronic‐ or fibro5c‐phase disease and significantly more prevalent in blast‐phase disease IDH co‐occurs with a JAK2, MPL or TET2 muta5on, and muta5onal frequency did not appear to be influenced by either the type of the coexis5ng muta5on or the presence or absence of each specific muta5on IDH‐mutated cases were more likely to be nullizygous for JAK2 46/1 haplotype Tefferi et al., Leukemia (2010) 24, 1302–1309
Clinical correlates and prognos0c relevance in PMF IDH‐mutated chronic‐phase PMF cases ohen belonged to a low‐ or intermediate‐risk category (p=0.32) IDH‐mutated blast‐phase PMF was less likely to display complex karyotype (p 0.001) CP‐PMF BP‐PMF BP‐MPN
Page 1 and 2: Le nuove mutazioni oltre JA
Page 3 and 4: NADP+-dependent isocitrate dehydrog
Page 5 and 6:  Reduc5on of NADPH and gl
Page 7 and 8: Somatic mutations of IDH1 and IDH2
Page 9: Tefferi et al., Leukemia (2010) 24,
Page 13 and 14: Oh ST et al, Blood. 2010
Page 15 and 16: ID DG JAK2V617F IDH LNK 1 2 PMF AML
Page 17: Dr.ssa ElisabGa Antonioli Dr.

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