IDH - siesonline
IDH - siesonline
IDH - siesonline
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First report of <strong>IDH</strong>1 muta5ons in myeloid malignancies: detected by sequencing an<br />
AML genome , preferen5ally clustering with intermediate risk AMLs<br />
Muta5ons first discovered in gliomas and secondary glioblastomas<br />
AML <br />
(16/188 mutated cases, 8%)<br />
R132C 8/16 (50%)<br />
R132H 7/16 (44%)<br />
R132S 1/188<br />
<strong>IDH</strong>2 R172 0/188<br />
Gliomas and secondary glioblastomas <br />
(about 80% mutated)<br />
R132C 7/161 (4%)<br />
R132H 142/161 (88%)<br />
R132S 4/161<br />
R172 0/188<br />
No indipendent prognos5c value with respect to overall survival in mul5variate analysis<br />
Mardis E et al, NEJM 2009; 361:1058-66<br />
Yan H et al. NEJM 2009; 360:765-9
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