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IDH - siesonline

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Different mutations have the same effect<br />

<strong>IDH</strong>
muta5ons<br />


R
132
(<strong>IDH</strong>1)<br />


R
140
(<strong>IDH</strong>2)<br />


R
172
(<strong>IDH</strong>2)<br />

<strong>IDH</strong>
muta5ons’<br />

frequency
in
78<br />

AML
samples<br />


7.7%<br />


9%<br />


4.4% 15.4%<br />

Ward et al, Cancer Cell 17, 225–234, March 16, 2010

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