The changing epidemiology of invasive aspergillosis

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Clinical relevance of Aspergillus isolation from ETA in critically ill patients Putative IPA 1. LRT sample positive for Aspergillus (entry criterion) 2. Compatible signs and symptoms 3. Abnormal medical imaging of chest 4. Either: (a) Host risk factors: - neutropenia, - hemato-oncologic malignancy + cytostatics - steroid treatment >20 mg/day - immunodeficiency (b) BAL:- semiquantitative positive culture +/++ and - positive cytologic exam (branching hyphae) Vandewoude K, et al. Crit Care 2006; 10: R31.
Spectrum from colonisation to invasive disease Colonisation Possible Putative Proven
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The changing epidemiology of invasive aspergillosis

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