The changing epidemiology of invasive aspergillosis
The changing epidemiology of invasive aspergillosis
The changing epidemiology of invasive aspergillosis
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Examples <strong>of</strong> at-risk patients and pace <strong>of</strong><br />
progression<br />
Risk <strong>of</strong> acquisition (and pace <strong>of</strong> progression)<br />
25%<br />
20%<br />
15%<br />
10%<br />
5%<br />
‘Normal immunity’, high inoculum<br />
Acute respiratory infection, i.e. influenza<br />
Chronic leukaemia<br />
HIV infection<br />
Short course glucocorticoids<br />
Temporary neutropenia<br />
AIDS<br />
Long term glucocorticoids etc<br />
Medical ICU, COPD + sepsis<br />
Solid organ transplant + rejection + CMV<br />
Leukemia and pr<strong>of</strong>ound neutropenia<br />
Allogeneic stem cell transplant + GVHD<br />
Relapsed/uncontrolled leukemia<br />
Degree <strong>of</strong> immunocompromise
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