Radiation Exposure Effects in Humans - Department of Energy ...
Radiation Exposure Effects in Humans - Department of Energy ...
Radiation Exposure Effects in Humans - Department of Energy ...
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Stochastic <strong>Effects</strong>: Hereditary<br />
• Three pr<strong>in</strong>cipal categories <strong>of</strong> genetic diseases<br />
– Mendelian<br />
• Autosomal dom<strong>in</strong>ant (Polydactyl, Hunt<strong>in</strong>gton’s chorea)<br />
• Autosomal recessive (Sickle-cell anemia, cystic fibrosis)<br />
• X-l<strong>in</strong>ked (Hemophelia, color-bl<strong>in</strong>dness)<br />
– Chromosomal aberrations (Down’s syndrome, embryonic<br />
death)<br />
– Mutlifactorial diseases (neural tube defect, cleft palate,<br />
diabetes, hypertension)<br />
• <strong>Radiation</strong>-<strong>in</strong>duced genetic diseases are not unique<br />
• Data on hereditary effects comes almost entirely from<br />
animal studies (i.e. Mega-mouse study)<br />
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