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Neurobiology of Somatization

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Theoretical Mechanisms: Neurobiologic<br />

• Variable CNS modulation <strong>of</strong><br />

incoming sensory information, e.g.,<br />

– conversion = excessive inhibition<br />

– somatization = inadequate inhibition.<br />

• Melzack R & Wall P. Pain mechanisms: A new theory.<br />

Science. 1965;150:971-979<br />

• Wall P. The gate control theory <strong>of</strong> pain mechanisms: a reexamination<br />

and re-statement. Brain. 1978;101:1-18.

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