Neurobiology of Somatization

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Evidence for overlap •Opioids reduce social pain –1978 profoundly reduced crying and motor agitation of puppy dogs subjected to social isolation –1988 same in rhesus monkeys •neuro-endocrine also blocked •naloxone blocked both – implicating the opioid receptor
Evidence for pain modulation • Right ventral pre-frontal cortex is reciprocally activated in social and somatic pain and may act to down-regulate the distress of physical and social pain. • Rx? •mindfulness training Social pain Physical pain
Page 1 and 2: Neurobiology of Somatization in < 2
Page 3 and 4: QUIZ: Who had more pain? A A B
Page 5 and 6: “By golly, you ARE crying on the
Page 7 and 8: DSM V Somatic Symptom Disorder •
Page 9 and 10: DSM V Illness Anxiety Disorder •
Page 11 and 12: Suffering in somatoform illness •
Page 13 and 14: Harrison’s Textbook 1962 (4th Edi
Page 15 and 16: Central Control Attention, emotion,
Page 17 and 18: PFC Cingulate & insula Somatosensor
Page 19 and 20: Theoretical Mechanisms: Biopsychoso
Page 21 and 22: Theoretical mechanisms Why rejectio
Page 23: Evidence for overlap •Surgical ci
Page 27 and 28: Patient Centered Care, a pilot RCT
Page 29 and 30: QUIZ: Who had more pain? A A B
Page 31 and 32: The abstract ends here! Questions?
Page 33: Proc Natl Acad Sci U S A. 2003;100:

Neurobiology of Somatization

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