Acetals

L A M B I O T T E & C I E S . A .
Acetals
Technical data
&Cie

L a m b i o t t e & C i e
Lambiotte & Cie started its activities in 1860 with forestry and sawmill exploitation,
producing railway sleepers. In a desire to increase the value of its wood waste
production, the company adopted an innovative carbonization process to convert
wood to charcoal. One of the chemical by-products of this distillation technology was
methanol. From 1901, Lambiotte’s interest in chemicals grew with the production of
formaldehyde from wood methanol. By 1970, Lambiotte’s passion for chemistry led to
the use of formaldehyde as a reagent in the production of acetals and hemicetals. Since
then, the company has continued to develop its expertise in production technologies,
making it a leader in the highly specialised field of acetals synthesis.
We at Lambiotte are proud to offer a wide range of industrial acetals, manufactured
with state-of-the-art equipment in a continuous process reaction. Our precision and
technical expertise in this specialist field guarantees the highest and most constant
quality and purity of product, allowing us to respond to each specific demand for
synthesis of acetals and chemical derivates from aldehydes and/or alcohols.
A dedicated support team is available to give the customer technical advice, providing
tailored formulae for many industrial sectors. In order to meet the customer’s needs,
we propose the services of our application laboratories in aerosols, cosmetics, coatings...
to develop customised formulae. Indeed, every department in Lambiotte, be it production,
quality control, sales, marketing, logistics or accounting is dedicated to customer satisfaction.
A world-wide network of specialised distributors ensures fast product availability,
delivery, and technical support to guarantee optimal client services.

A C E T A L S P R O D U C T R A N G E
METHYLAL - ETHYLAL - BUTYLAL - 1,3–DIOXOLANE - GLYCEROL FORMAL
Acetals belong to a specific chemical family, distinct from ethers.
Lambiotte’s acetals are produced by reactions between alcohols and aldehydes.
The acetal molecule can be either linear or cyclic.
Depending on their chemical structure, the water miscibility is partial or complete.
All of them are fully miscible with organic solvents.
In presence of water, the acetal solvents are very stable in a wide range of pH : from pH 4 to pH 14.
Compared to ethers, acetals form less peroxide.
With regard to their toxicity and ecotoxicity, Lambiotte’s acetals show very good profiles to health
and environment. Their atmospheric chemistry behaviour is also very good. GWP and POCP are low,
ODP is zero.
Thanks to their high solvent power, acetals are widely used to solubilise a large range of products,
such as resins, active ingredients, additives, etc.
Acetals are also used as reagents and solvents in chemical and pharmaceutical synthesis.
METHYLAL 4
&Cie&Cie ETHYLAL 6
&Cie&Cie BUTYLAL 8
&Cie&Cie 1,3-DIOXOLANE 10
&Cie&Cie GLYCEROL FORMAL 12
&Cie&Cie APPLICATIONS 14
&Cie&Cie SOLVENT PROPERTY TABLE 15
&Cie&Cie LAMBIOTTE’S LOCALISATION 16
&Cie&Cie

L A M B I O T T E & C I E S. A.
M E T H Y L A L
Description
Molecular formula C 3
H 8
O 2
Chemical structure CH 3
-O-CH 2
-O-CH 3
Synonym
Dimethoxymethane (DMM)
CAS N° 109-87-5
EINECS N° 203-714-2
INCI name
Methylal
Physical Properties
Molecular weight 76.08
Density (g/cm 3 ) 20°C 0.861
Vapour density 2.6
Boiling point (°C) 101 325 Pa 42.3
Freezing point (°C) -104.8
Flash point (°C)
Closed cup (Pensky-Martens) -18
Open cup (Cleveland) -18
Vapour pressure (bar) 20°C (ASTM D 323 modified) 0.40
Kinematic viscosity (10 -7 m 2 /s) 25°C 3.71
Refractory index η 20 D 1.3531
Explosion limits (Vol%)
LEL 20 : 2.2
UEL 20 : 19.9
Autoignition temperature (°C) (ASTM E 659) 237
Surface tension (mN/m) 25°C 21.20
Evaporation rate compared to
Diethyl ether (=1) 1.36
(Following DIN 53170)
Butyl acetate (=1) 0.11
Solubility of the acetal in water (%) 32.3
Solubility of water in the acetal (%) 4
Solvent power
Kauri-butanol index (ASTM D 1133-90) measured with gum 4938 101
gum 4939 164
Solubility parameters (MPa 1/2 )
Hildebrand: Total δ 18.24
Hansen: Dispersion δ d 14.83
Polarity δ p 6.01
Hydrogen bond δ h 8.76
Azeotropes
% Weight % Weight B.P. temperature (°C) Pressure (Pa)
Methylal
98.70
Methylal
91.80
Water
1.30 42 101 320
Methanol
8.20 41.85 101 320

Toxicological Information
Inhalation, mouse:
LC 50
= 18354 ppm / 7 hours
Inhalation, rat:
LC 50
= 15000 ppm
Oral, rabbit:
LD 50
= 5700 mg / kg
Oral, rat / wistar:
LD 50
= 6415 mg / kg
Oral, mouse:
LD 50
= 6950 mg / kg
Skin irritation, rabbit:
none to slight cutaneous reaction
Skin sensitization, guinea pig:
not allergenic (Magnuson & Kligman test)
Subacute inhalation, rat (8 days):
NOEL = 4000 ppm / 6 hours
Subchronic inhalation, rat (13 weeks): NOEL = 2000 ppm / 6 hours / 5 days
Draize test, eye, rabbit, 100 μl:
minor to moderate irritation
Ames test:
no mutagenic activity both in presence or in absence
of metabolic activation
Teratogenicity, inhalation, rat, 10068 ppm: no effect on embryofoetal development
Carcinogenicity: not listed by ACGIH, IARC, NTP or CA Prop 65.
Ecological Information
No effect observed on:
- Bacteria (Pseudomonas Putida)
- Daphnids (Daphnia Magna)
- Fish (Brachydanio Rerio)
- Green algae (Chlorella Vulgaris)
Methylal shows a positive biodegradability (ISO/DIS 8192)
Regulatory Information
Europe EINECS (European Inventory of Existing Commercial chemical Substances) 203-714-2
Germany WGK (Wassergefährdungsklasse) 1
USA TSCA (Toxic Substances Control Act) Listed on the TSCA inventory
Health & Safety Reporting List Effective 6/1/87, Sunset 12/19/95
California, New Jersey, Pennsylvania,
Minnesota, Massachusetts
California Prop 65
California No Significant Risk Level
Mentioned on the following
states right-to-know lists
Not listed
Canada DSL/NDSL (Domestic Substances List) (Non-Domestic Substances List) Listed on the DSL List
WHMIS (Workplace Hazardous Materials Information System)
Canadian Ingredient Disclosure List
This product has a WHMIS
classification of B2
Listed on the Canadian IDL
Australia AICS (Australia Inventory of Chemical Substances) Listed on the AICS inventory
Japan ENCS Japanese Gazette 2-498
Korea ECL (Korean Existing Chemicals List) KE-11074
Philippines PICCS (Philippines Inventory of Chemicals and Chemical Substances) Listed on the PICCS inventory

L A M B I O T T E & C I E S. A.
E T H Y L A L
ETHYLAL
Molecular formula C 5
H 12
O 2
Chemical structure CH 3
-CH 2
-O-CH 2
-O-CH 2
-CH 3
Synonym
Diethoxymethane (DEM)
CAS N° 462-95-3
EINECS N° 207-330-6
Physical Properties
Molecular weight 104.15
Density (g/cm 3 ) 20°C 0.830
Vapour density 3.6
Boiling point (°C) 101 325 Pa 88
Freezing point (°C) - 66
Flash point (°C)
Closed cup (Pensky-Martens) - 7
Open cup (Cleveland) 6
Vapour pressure (bar) 20°C (ASTM D 323 modified) 0.17
Kinematic viscosity (10 -7 m 2 /s) 25°C 5.07
Refractory index η 20 D 1.3725
Explosion limits (Vol%)
LEL : 2.1
UEL : 20
Autoignition temperature (°C) (ASTM E 659) 174
Surface tension (mN/m) 25°C 21.62
Evaporation rate compared to
Diethyl ether (=1) 3
(Following DIN 53170)
Butyl acetate (=1) 0.25
Solubility of the acetal in water (%) 6.33
Solubility of water in the acetal (%) 1.21
Solvent power
Kauri-butanol index (ASTM D 1133-90) measured with gum 4938 92
gum 4939 120
Solubility parameters (MPa 1/2 )
Hildebrand: Total δ 17.06
Hansen: Dispersion δ d 14.87
Polarity δ p 4.67
Hydrogen bond δ h 6.95

Azeotropes
Binary (non homogeneous)
% Weight Ethylal % Weight Water B.P. temperature (°C) Pressure (Pa)
90.00 10.00 75.2 102 390
Binary (homogeneous)
% Weight % Weight B.P. temperature (°C) Pressure (Pa)
Ethylal
58
Methyl Ethyl Formal
95.60
Ternary
Ethanol
42 74.2 101 320
Water
4.40 61.62 101 320
% Weight ethylal % Weight ethanol % Weight water B.P. temperature (°C) Pressure (Pa)
62.38 22.68 14.93 72.8 101 325
Toxicological Information
Inhalation, rat:
Oral, rabbit:
Oral, rat:
Dermal, rat:
Skin irritation, guinea pig:
Skin sensitization, guinea pig:
Eye irritation, rabbit:
Subchronic inhalation, rat (16 exposures):
LC 50
= 6643 ppm / 6 hours
LD 50
= 2604 mg / kg
LD 50
= 3536 mg / kg
LD 50
> 20 ml / kg
very slight
none (Magnuson & Kligman test)
slight
NOEL = 750 ppm
Ecological Information
Ethylal has:
- a low potential to affect aquatic organisms
- a low potential to bioconcentrate
- a low potential to persist in the environment
NOEC (Daphnids) = 162 mg / l
Regulatory Information
Europe EINECS (European Inventory of Existing Commercial chemical Substances) 207-330-6
USA TSCA (Toxic Substances Control Act) Listed on the TSCA inventory
Canada DSL/NDSL (Domestic Substances List) (Non-Domestic Substances List) Listed on the DSL List
Australia AICS (Australia Inventory of Chemical Substances) Listed on the AICS inventory
Korea ECL (Korean Existing Chemicals List) KE-23849
Philippines PICCS (Philippines Inventory of Chemicals and Chemical Substances) Listed on the PICCS inventory

L A M B I O T T E & C I E S. A.
B U T Y L A L
Description
Molecular formula C 9
H 20
O 2
Chemical structure CH 3
-(CH 2
) 3
-O-CH 2
-O-(CH 2
) 3
-CH 3
Synonym
Dibutoxymethane (DBM)
CAS N° 2568-90-3
EINECS N° 219-909-0
Physical Properties
Molecular weight 160.26
Density (g/cm 3 ) 20°C 0.8354
Vapour density
Not available
Boiling point (°C) 101 325 Pa 180.5
Freezing point (°C) - 58.1
Flash point (°C)
Closed cup (Pensky-Martens) 62
Open cup (Cleveland) 64
Vapour pressure (bar) 20°C (ASTM D 323 modified)

Toxicological Information
Oral, rat:
Dermal, rat:
Eye irritation, rabbit:
Skin irritation, rabbit:
Skin sensitization, guinea pig:
Ames test:
LD 50
= 6873 mg / kg
LD 50
> 2000 mg / kg
non irritant
non irritant
no sensitization (Magnuson & Kligman test)
no mutagenic effect on 5 strains of Salmonella
typhimurium and one strain of Escherichia colli,
with or without metabolic activation (S9 mix)
Ecological Information
Aquatic: The aerobic biodegradability of butylal has been measured by the biochemical oxygen
demand in two phases closed test bottles. Butylal was emulsified with surfactants.
Butylal is slightly biodegradable.
Regulatory Information
Europe EINECS (European Inventory of Existing Commercial chemical Substances) 219-909-0
Germany WGK (Wassergefährdungsklasse) 1
Canada DSL/NDSL (Domestic Substances List) (Non-Domestic Substances List) Listed on DSL List

L A M B I O T T E & C I E S. A.
1 , 3 - D I O X O L A N E
Description
Molecular formula C 3
H 6
O 2
Chemical structure
Synonym
1,3-dioxacyclopentane
CAS N° 646-06-0
EINECS N° 211-463-5
INCI name
Elcotal DX
Physical Properties
Molecular weight 74.08
Density (g/cm 3 ) 20°C 1.06
Vapour density 2.6
Boiling point (°C) 101 325 Pa 74-75
Freezing point (°C) -95
Flash point (°C)
Closed cup (Pensky-Martens) -6
Open cup (Cleveland) 2
Vapour pressure (bar) 20°C (ASTM D 323 modified) 0.09
Kinematic viscosity (10 -7 m 2 /s) 25°C 5.53
Refractory index η 20 D 1.4005
Explosion limits (Vol%)
LEL 45 : 2.1
UEL 65 : 20.5
Autoignition temperature (°C) (ASTM E 659) 274
Surface tension (mN/m) 25°C 34.3
Evaporation rate compared to
Diethyl ether (= 1) 3.60
(Following DIN 53170)
Butyl acetate (= 1) 0.29
Solubility of the acetal in water (%)
Fully miscible
Solubility of water in the acetal (%)
Fully miscible
Solvent power
Kauri-butanol index (ASTM D 1133-90) measured with gum 4938 >218
gum 4939 >207
Solubility parameters (MPa 1/2 )
Hildebrand: Total δ 22.07
Hansen: Dispersion δ d 16.95
Polarity δ p 7.85
Hydrogen bond δ h 11.76
Azeotrope
Binary (homogeneous)
% Weight 1,3-dioxolane % Weight water B.P. temperature (°C) Pressure (Pa)
91.30 8.70 71.7 102 390
10

Toxicological Information
Inhalation, rabbit:
Inhalation, male rat:
Inhalation, Sprague-Dawley rat:
Inhalation, guinea pig:
Oral, mouse:
Oral, rat:
Dermal, albino rabbit:
Subchronic inhalation, rat (13 weeks):
LC 50
= 118 mg / l
LC 50
= 87mg / l / 4 hours
LC 50
= 68.4 mg / l
LC 50
= 166 mg / l / 4 hours
LD 50
= 7460 mg / kg
LD 50
= 5800 mg / kg
LD 50
= 15 000 mg / kg
NOEL = 300 ppm
Teratogenicity, oral, 10 or 20% of the LD 50
one each day 5 days/week (8 weeks):
Teratogenicity, inhalation, rat,
no loss of foetuses occurred
10 and 20% of the LC 50
: no increases in pre- or post-implantation foetal losses
Teratogenicity, intragastric, rat,
10 and 20% of the LD 50
: no increases in pre- or post-implantation foetal losses
Ames test up to 10 μl:
Ames test at the equivalent of 50 μl / plate:
no mutagenic activity both in presence or in absence
of microsomal enzyme preparation
no mutagenic activity both in presence or in absence
of metabolic activation
Carcinogenicity: not listed by ACGIH, IARC, NTP or CA Prop 65
Ecological Information
Terrestrial:
Aquatic:
Atmospheric:
High mobility in soil and leaching may occur. 1,3-dioxolane may volatilize
from moist soil.
Volatilization half-lives of 34 hr and 15 days have been estimated for a model river
and a model environmental pond, respectively. Adsorption to sediment and bioconcentration
in aquatic organisms may not be important.
Expected to exist almost entirely in the vapour phase in the ambient atmosphere.
Will not bioconcentrate but may slightly biodegrade.
Regulatory Information
Europe EINECS (European Inventory of Existing Commercial chemical Substances) 211-463-5
Germany WGK (Wassergefährdungsklasse) 1
USA TSCA (Toxic Substances Control Act) Listed on the TSCA inventory
California Prop 65
Not listed
California No Significant Risk Level
Canada DSL/NDSL (Domestic Substances List) (Non-Domestic Substances List) Listed on DSL List
WHMIS (Workplace Hazardous Materials Information System)
This product has a WHMIS
classification of B2
Japan ENCS Japanese Gazette 5-500
Korea ECL (Korean Existing Chemicals List) KE-12027
Philippines PICCS (Philippines Inventory of Chemicals and Chemical Substances) Listed on the PICCS inventory
11

L A M B I O T T E & C I E S. A.
G L Y C E R O L F O R M A L
Description
Molecular formula C 4
H 8
O 3
Chemical structure
OH
CH 2
OH
+
(1) 52% (2) 48%
Synonyms
(1) 5-hydroxy-1,3-dioxane
(2) 4-hydroxymethyl-1,3-dioxolane
CAS N° 4740-78-7 and 5464-28-8
EINECS N° 225-248-9 and 226-758-4
INCI name
Elcotal GF
Physical Properties
Molecular weight 104.11
Density (g/cm 3 ) 20°C 1.215
Vapour density
Not available
Boiling point (°C) 101 325 Pa 191-195
Freezing point (°C)
Not available
Flash point (°C)
Closed cup (Pensky-Martens) 99
Open cup (Cleveland) 98
Vapour pressure (bar) 20°C (ASTM D 323 modified) 400
Surface tension (mN/m) 25°C 44.49
Evaporation rate compared to
Diethyl ether (= 1)
Not available
(Following DIN 53170)
Butyl acetate (= 1)
Not available
Solubility of the acetal in water (%)
Fully miscible
Solubility of water in the acetal (%)
Fully miscible
Solvent power
Kauri-butanol index (ASTM D 1133-90) measured with gum 4938 71
gum 4939 74
Solubility parameters (MPa 1/2 )
Hildebrand: Total δ 25.79
Hansen: Dispersion δ d 16.37
Polarity δ p 11.99
Hydrogen bond δ h 19.63
12

Toxicological Information
Oral, mouse:
LD 50
= 8 ml / kg
Oral, rat:
LD 50
= 8 ml / kg
Intraperitoneal, mouse:
7.5 ml / kg
Intraperitoneal, rat:
9.5 ml / kg
Intravenous injection, mouse:
LD50 = 4 ml / kg
Mutagenicity:
- non-mutagenic both on the Salmonella typhimurium
strains TA1535, TA1537, TA1538, TA98 and TA100 and
on the pulmonary cell line of Chinese hamster V87.
- no clastogenic effect in mice micronucleus assay.
RTECS # Registry of Toxic Effects
of Chemical Substances: JH 8390000
Carcinogenicity: not listed by ACGIH, IARC, NTP or CA Prop 65
Regulatory Information
CAS 5464-28-8 Europe EINECS (European Inventory of Existing Commercial chemical
Substances)
226-758-4
Australia AICS (Australia Inventory of Chemical Substances) Listed on the AICS inventory
Canada
Asia Pacific
DSL/NDSL
(Domestic Substances List) (Non-Domestic Substances List)
CAS 4740-78-7 Europe EINECS (European Inventory of Existing Commercial chemical
Substances)
Canada
Asia Pacific
DSL/NDSL
(Domestic Substances List) (Non-Domestic Substances List)
Not listed on DSL List
Not listed on NDSL List
Listed on ASIA-PAC
225-248-9
Not listed on DSL List
Not listed on NDSL List
Listed on ASIA-PAC
13

L A M B I O T T E & C I E S. A.
A P P L I C A T I O N S
Coatings
APPLICATIONS Methylal Ethylal Butylal
Paints
1,3
Dioxolane
Metallic ● ●
Sprayed / Aerosol ● ●
Wood
●
Varnishes ● ●
UV curing
Glycerol
Formal
Paint strippers ● ● ● ●
Inks Ink jet printer ● ●
Adhesives
Cleaning
Aerosols
Cosmetics
Pharmaceuticals
Veterinary
Synthesis
Heavy duty
Cosmetics
Para
pharmaceuticals
(OTC)
Hair care (pumps)
Skin care
Body care
Colour
PVC
PU glues
Heat sealable adhesives
Sleeves
Contact glues ● ● ● ●
Degreasing ● ● ● ●
Graffiti cleaner ● ●
Tars, bitumen
All others ● ● ● ● ●
Hair sprays ● ●
Deodorants ● ●
Freezing sprays
●
Plaster sprays ● ●
Haemostatic sprays
Household ● ●
●
Technical ● ●
Automotive ● ●
Styling water and mousse ● ●
Fixing water and mousse ● ●
Sun product ● ●
After sun
Body splash
Legs, feet cooler
●
●
●
Nail varnishes ● ●
Varnish removers ● ●
Synthesis ● ● ● ●
Galenic Antiseptic ●
Injectable
Topical use Sprays ●
Chemicals
Purification
Reaction solvent ● ● ● ● ●
Reagent ● ● ● ● ●
Polymers, resins ● ● ●
Fragrances, aromas ● ●
Perfumes ● ● ● ●
Extraction ● ● ● ●
Cristallisation ● ● ●
HPLC ● ● ●
Chemicals Stabilizers Brominated solvents ● ●
Textile / Leather
Solubilizers Fluorinated resins ●
Enduction Synthetic leather ●
Agrochemicals ● ●
Polyurethanes
Blowing agent
●
Cleaning ● ●
●
●
●
●
●
●
●
14

S O L V E N T P R O P E R T Y T A B L E
Methylal Ethylal Butylal 1,3 - Dioxolane Glycerol formal
Molecular formula C 3
H 8
O 2
C 5
H 12
O 2
C 9
H 20
O 2
C 3
H 6
O 2
C 4
H 8
O 3
Chemical structure CH 3
-O-CH 2
-O-CH 3
CH 3
-CH 2
- O-CH 2
-O-CH 2
-CH 3
CH 3
-(CH 2
) 3
- O-CH 2
-O-(CH 2
) 3
-CH 3
OH
CH2 OH
(1) 52%
+
(2) 48%
Synonym Dimethoxymethane Diethoxymethane Dibutoxymethane 1,3-dioxacyclopentane
(1) 5-hydroxy-1,3-dioxane
(2) 4-hydroxymethyl – 1,3 - dioxolane
CAS N° 109-87-5 462-95-3 2568-90-3 646-06-0 4740-78-7 and 5464-28-8
EINECS N° 203-714-2 207-330-6 219-909-0 211-463-5 225-248-9 and 226-758-4
Molecular weight 76.08 104.15 160.26 74.08 104.11
Density (g/cm 3 ) 20°C 0.861 0.830 0.8354 1.06 1.215
Vapour density 2.6 3.6 Not available 2.6 Not available
Boiling point (°C) 101 325 Pa 42.3 88 180.5 74-75 191-195
Freezing point (°C) - 104.8 -66 - 58.1 -95 Not available
Flash point (°C)
Closed cup (Pensky-Martens) -18 -7 62 -6 99
Open cup (Cleveland) -18 6 64 2 98
Vapour pressure (bar) 20°C (ASTM D 323 modified) 0.40 0.17 218 71
Gum 4939 164 120 75 >207 74
Hildebrand total δ 18.24 17.06 16.23 22.07 25.79
Solubility parameters
(MPa 1/2 )
Hansen
Dispersion δ d 14.83 14.87 14.70 16.95 16.37
Polarity δ p 6.01 4.67 3.43 7.85 11.99
Hydrogen bond δ h 8.76 6.95 5.96 11.76 19.63
To the best of their knowledge, the information contained herein is accurate. However, Lambiotte & Cie do not assume any liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of the material and whether there is any infringement of patents is the sole responsibility of the user. All chemicals may present unknown health hazards and should be used with caution.
Any potential hazards associated with these products of which Lambiotte & Cie may be aware are described in the Material Safety Data Sheet (MSDS) for these products; however, Lambiotte & Cie cannot guarantee
that those are the only hazards which exist, and users of any chemical should satisfy themselves by independent investigation of the current scientific and medical knowledge the material can be used safely.

&Cie
OOSTENDE
F
NL
ANTWERPEN
bRUSSeLS
NAMUR
CHARLEROI
N
e2
maRbeHaN
LIEGE
ARLON
D
L
LUXEMBOURG
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