Bacteriophage application for elimination of E coli for elimination of ...
Bacteriophage application for elimination of E coli for elimination of ...
Bacteriophage application for elimination of E coli for elimination of ...
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<strong>Bacteriophage</strong> Application<br />
• <strong>Bacteriophage</strong>s (phages) are natural<br />
predators <strong>of</strong> bacteria including E. <strong>coli</strong><br />
O157:H7<br />
• Viruses (lytic) target specific receptors on<br />
the bacteria, use host machinery to<br />
generate new phage progeny and lyse<br />
host cell releasing new progeny<br />
• Self-replicating, self-limiting, very specific<br />
to targets<br />
• FDA in United States approved phage<br />
preparations p <strong>for</strong> eradication <strong>of</strong> Listeria<br />
monocytogenes<br />
• Phage cocktails can increase specificity<br />
and reduce likelihood <strong>of</strong> resistance<br />
• Phage are ubiquitous in the environment
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