tumor cell biology program - Sylvester Comprehensive Cancer Center

Shostak, LD, Ludlow, J, Fisk, J,
Pursell, S, Rimel, BJ, Nguyen, D,
Rosenblatt, JD, Planelles V. Roles of p53
and caspases in the induction of cell cycle
arrest and apoptosis by HIV-1-vpr. Experimental
Cell Research 251:156,1999.
Penichet Manuel, L, Challita-Eid,
PM, Shin, Seung-Uon, Sampogna, SL,
Rosenblatt, JD, Morrison, SL. In vivo
properties of three human HER2/neu
expressing murine cell lines in immunocompetent
mice. Laboratory Animals
Science 73:2831, 1999.
Klimatcheva, E, Rosenblatt, JD,
Planelles, V. Lentiviral vectors and gene
therapy. Frontiers in Bioscience 4:D481,
1999.
Mahmood, K, Tolba, K, Federoff,
HJ, Rosenblatt, JD. The role of HSV
amplicon vectors in cancer gene therapy.
Gene Therapy and Molecular Biology,
Boulikas T (ed), 4:209, 1999.
Rimel, BJ, Rosenblatt, JD,
Planelles, V. HTLV-II. Encyclopedia of
Virology, Second Edition, Granoff, A,
Webster, RG (eds), Academic Press, San
Diego, CA, 1999.
Ifthikharuddin, JJ, Mieles, LA,
Rosenblatt, JD, Ryan, CK, Sahasrabudhe,
DM. CD-20 expression in
post-transplant lymphoproliferative disorders:
Treatment with Rituximab.
American Journal of Hematology
65:171, 2000.
Ifthikharuddin, JJ, Rosenblatt, JD.
Type C oncoviruses-Human T-cell
lymphotropic virus Types I and II.
Principles and Practice of Infectious Diseases,
5 th Edition, Volume 2. Eds:
Mandell GL, Bennett, JE and Dolin, WB
Saunders Co., Philadelphia, PA, 2000.
Coliccio F, Griggs, J, Rosenblatt,
JD. Basic concepts in drug development
clinical trials. Clinical Oncology, Eighth
Edition, Ed: Phillip Rubin. WB Saunders
Co, Philadelphia 160, 2001.
Rubin, Williams, Okunieff, Rosenblatt
JD, Sitzmann. Statement of the
clinical oncologic problem. Clinical
Oncology, Eighth Edition, Ed: Phillip
Rubin. WB Saunders Co, Philadelphia
1, 2001.
Tolba, K, Federoff, HJ, Rosenblatt,
JD. Gene therapy for cancer. Clinical
Oncology, Eighth Edition, Ed: Philip
Rubin. WB Saunders Co, Philadelphia
168, 2001.
Maurer, C, Harrington, WJ, Gill, P,
Kampe, CE, Rosenblatt, JD. Adult T-
cell leukemia/lymphoma. Cancer Treatment,
5 th Edition, Chapter 96, Ed:
Haskell CM, WB Saunders Co, Philadelphia
1474, 2001.
Khorana, A, Rosenblatt, JD, Young,
F. Immunopathogenesis of HIV and
HTLV-1 infection: Mechanisms for
Lymphomagenesis. Cancer Treatment
and Research Series; HIV-Associated
Malignancies. Ed: Joseph A. Sparano,
M.D., Kluwer Academic Publishers,
Norwell, MA, Chapter 2:19, 2001.
Chen, Y, Pandya, K, Keng, PP, Feins,
R, Raubertas, R, Smudzin, T, Rosenblatt
JD, Okunieff P. Schedule-dependent
pulsed Paclitaxel radiosensitization for
thoracic malignancy. American Journal
of Clinical Oncology 24(5): 432, 2001.
Belly, RT, Rosenblatt, JD,
Steinmann, M, Toner, J, Sun, J, Shehadi,
J, Peacock, J, Raubertas, RF, Jani, N,
Ryan, CK. Detection of mutated K-12
ras in historically negative lymph nodes
as an indicator of poor prognosis in stage
II colorectal cancer. Clinical Colorectal
Cancer 1:110, 2001.
Renda, MJ, Rosenblatt, JD,
Klimatcheva, E, Demeter, L, Bambara,
R, Planelles, V. Mutation of the methylated
tRNA Lys3 residue A58 disrupts reverse
transcription and inhibitors
replication of the Human Immunodeficiency
Virus, Type 1. Journal of Virology
75, 20:9671, 2001.
Klimatcheva, E, Planelles, V, Day,
S, Fulreader, F, Renda, MJ, Rosenblatt,
JD. Defective lentiviral vectors are efficiently
trafficked by HIV-1 and Inhibit
its replication. Molecular Therapy 3:928,
2001.
Peniche, ML, De la Cruz, JS,
Challita-Eid, PM, Rosenblatt, JD and
Morrison, SL. A murine B cell lymphoma
expressing human HER2/neu
undergoes spontaneous tumor regression
and elicits anti-tumor immunity. Cancer
Immunology Immunotherapy
49:649, 2001.
Tolba, K.A., Bowers, Wm. J.,
Hilchey, S.P., Halterman, M.W.,
Howard, D.F., Giuliano, R.E., Federoff,
H.J., Rosenblatt, JD. Development of
HSV-1 Amplicon-based immunotherapy
for Chronic Lymphocytic Leukemia.
Blood 98:287, 2001.
Karp, J, Lancet, J., Kaufman, S.,
End, D., Wright, J.J., Horak, I., Tidwell,
M., Liesveld, J., Ange, D., Buddharaju,
L., Gojo, I., Highsmith, W.E., Rybak,
M.E., Rosenblatt, JD. Phase I Clinical
trial of R115777 in adults with Acute
Leukemia. Blood 97:3361, 2001.
HIGHLIGHTS/DISCOVERIES
• Development of novel antibodychemokine
and antibody-costimulatory
ligand fusion proteins with dual
function and preserved targeting capabilities.
• Development of a novel strategy for
gene therapy of HIV-1 using mutations
introduced into tRNA LYS3 primers.
• Demonstration of the potential role for
HSV amplicon vectors in gene therapy
of malignancy, particularly CLL.
• Demonstration of trafficking and inhibition
by defective HIV-1 as a novel
approach to HIV-1 gene therapy.
34
UM/Sylvester Comprehensive Cancer Center Scientific Report 2002