tumor cell biology program - Sylvester Comprehensive Cancer Center

gene within that region, named I6BL, a
strong candidate for the UVB-1 gene.
The goal of our research is to investigate
whether the I6BL gene that was found is
really the UVB-1 gene. If this is found
to be true, the human homolog gene will
be found and analyzed to determine its
role in UVB induced immunosuppression
and immunosurveillance. In case
these experiments exclude the I6BL gene
as the UVB-1 gene, they will search the
UVB-1 region extensively for the presence
of the UVB-1 gene and further analyze
it once they find it.
Once the UVB-1 gene has been isolated,
researchers will be in the position
to combine the current evidence regarding
environmental carcinogens with our
knowledge of genetic susceptibility factors
so that they might improve the understanding
of the pathogenesis of skin
cancer and begin developing an approach
for the early diagnosis and prevention of
this disease.
PUBLICATIONS
Scordi, IA, Nassiri, M, Hanly, A and
Vincek, V. Interleukin 11 (IL-11) reduces
apoptosis in UVB irradiated mouse skin.
Dermatology 199:296, 1999.
Handel-Fernandez, ME, Kurimoto,
I, Streilein, JW and Vincek, V. Genetic
mapping and physical cloning of UVBsusceptibility
region in mice. Journal of
Investigative Dermatology 113:224,
1999.
Handel-Fernandez, ME and Vincek,
V. Sequence analysis and expression of a
mouse homologue of human I kappa BL
gene. Biochimica et Biophysica Acta
1444:306, 1999.
Handel-Fernandez, ME and Vincek,
V. Early cancer detection by microsatellite
marker analysis. Medical Hypothesis
53:114, 1999.
Scordi, TA and Vincek, V. Timecourse
study of UVB-induced cytokine
induction in whole mouse skin.
Photodermatology Photoimmunology
Photomedicine 16:67, 2000.
Walsh, PJ, Heitz, MJ, Campbell,
CE, Cooper, GJ, Medina, M, Wang, YS,
Goss, GG, Vincek, V, Wood CM and
Smith CP. Molecular characterization of
a urea transporter in the gill of the gulf
toadfish. Journal of Experimental Biology
203:2357, 2000.
Handel-Fernandez, ME, Nassiri, M,
Arana, M, Perez, MM, Fresno, M, Nadji,
M and Vincek, V. Mapping of geneticdeletions
on the long arm of chromosome
22 in human pancreatic adenocarcinomas.
Anticancer Research 20:
4451, 2000.
36
UM/Sylvester Comprehensive Cancer Center Scientific Report 2002