DKFZ - HBIGS

Prof. Dr. Peter Lichter
16/10/1957
CURRICULUM VITAE
Division Molecular Genetics
German Cancer Research Center (DKFZ)
69120 Heidelberg, Germany
Phone: +49-(0)6221-42 4619
Fax: +49-(0)6221-42 4639
E-mail: m.macleod@dkfz.de
2005 – present Member of the Wissenschaftsrat
2004 – present Member of the Scientific Program Committee of the European Society of
Human Genetics
2004 – present Member of the Hinterzartener Kreis (DFG)
2003 Interim Director of the Management Board of the DKFZ
2000 – present Full Professor at the Faculty of Medicine (“C4 Professor”), University of
Heidelberg
1995 Habilitation and venia legendi in Molecular Human Genetics, Faculty of
Medicine, University of Heidelberg.
1992 – present Head of the Division "Organization of Complex Genomes" (since 2002
named “Molecular Genetics”), DKFZ Heidelberg
1990 – 1992 Head of the project group "Organization of complex genomes", DKFZ
Heidelberg
1987 – 1989 Fellow of the Deutsche Forschungsgemeinschaft
1986 – 1990 Postdoctoral Scientist in the laboratory of Prof. D.C. Ward, Dept. of
Genetics, School of Medicine, Yale University, New Haven (USA)
1986-1987 Long term Fellowship, European Molecular Biology Organization
(EMBO)
1983/1986 Graduation (Biology) and PhD degree (summa cum laude), University of
Heidelberg
1981 – 1986 Fellow of the "Studienstiftung des Deutschen Volkes"
HONORS
2006 Award “Stiftung für die Erforschung und Bekämpfung von
Krebskrankheiten”
2004 Award “Deutsche Krebshilfe”
2002 Deutscher Krebspreis (German Cancer Award)
1993 “Walther und Christine Richtzenhain" Award (1993)
1992 Award of the (German) Society for Human Genetics
1991 "Karl-Freudenberg" Award of the Academy of Sciences, Heidelberg
FIELDS OF INTEREST
Pathomechanisms of tumor development, tumor markers, molecular profiling of tumor
cells, genome organization and gene function.

SELECTED PUBLICATIONS (SINCE 2000)
Mertens D, Wolf S, Tschuch C, Mund C, Kienle D, Ohl S, Schroeter P, Lyko F, Dohner H,
Stilgenbauer S, Lichter P (2006) Allelic silencing at the tumor-suppressor locus 13q14.3
suggests an epigenetic tumor-suppressor mechanism. Proc Natl Acad Sci USA 103:
7741-7746.
Thuerigen O, Schneeweiss A, Toedt G, Warnat P, Hahn M, Kramer H, Brors B, Rudlowski
C, Benner A, Schuetz F, Tews B, Eils R, Sinn HP, Sohn C, Lichter P (2006) Gene
expression signature predicting pathologic complete response with gemcitabine,
epirubicin, and docetaxel in primary breast cancer. J Clin Oncol 24: 1839-1845.
Schmidt U, Richter K, Berger AB, Lichter P (2006) In vivo BiFC analysis of Y14 and NXF1
mRNA export complexes: preferential localization within and around SC35 domains. J
Cell Biol 172: 373-381.
Nessling M, Richter K, Schwaenen C, Roerig P, Wrobel G, Wessendorf S, Fritz B, Bentz
M, Sinn HP, Radlwimmer B, Lichter P (2005) Candidate genes in breast cancer revealed
by microarray-based comparative genomic hybridization of archived tissue. Cancer Res
65: 439-447.
Neben K, Korshunov A, Benner A, Wrobel G, Hahn M, Kokocinski F, Golanov A, Joos S,
Lichter P (2004) Microarray-based screening for molecular markers in medulloblastoma
revealed STK15 as independent predictor for survival. Cancer Res 64: 3103-3111.
Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, Radlwimmer B, Kestler HA,
Haslinger C, Stilgenbauer S, Döhner H, Bentz M, Lichter P (2004) Automated array based
genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and
discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 101: 1039-1044.
Gorisch SM, Wachsmuth M, Ittrich C, Bacher CP, Rippe K, Lichter P (2004) Nuclear body
movement is determined by chromatin accessibility and dynamics. Proc Natl Acad Sci
USA 101: 13221-13226:
Korshunov A, Neben K, Wrobel G, Tews B, Benner A, Hahn M, Golanov A, Lichter P
(2003) Gene expression patterns in ependymomas correlate with tumor location, grade,
and patient age. Am J Pathol 163: 1721-1727.
Fritz B, Schubert F, Wrobel G, Schwaenen C, Wessendorf S, Nessling M, Korz C, Rieker
RJ, Montgomery K, Kucherlapati R, Mechtersheimer G, Eils R, Joos S, Lichter P (2002)
Microarray-based copy number and expression profiling in dedifferentiated and
pleomorphic liposarcoma. Cancer Res 62: 2993-2998.
Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L, Dohner K, Bentz
M, Lichter P (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. N
Engl J Med 343: 1910-1916.
Lichter P, Tang CC, Call K, Hermanson G, Evans GA, Housman D, Ward DC (1990) High
resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones.
Science 247: 64-69.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of numerous thesis and thesis advisory committees
International reviewer of doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
Cordula Tschuch, PhD (2006) Functional Characterization of Candidate Genes in the
Pathogenesis of B-Cell Chronic Lymphocytic Leukemia” (B-CLL)
Current occupation: Postdoctoral fellow, DKFZ Heidelberg
Otto Mannherz, PhD (2006) Screening zur Identifizierung pro- und anti-apoptotischer
Gene mittels reverser Transfektions-zellarrays
Current occupation: Industry, Neu-Isenburg
Björn Tews, PhD (2006) Identifizierung pathogenetisch relevanter Suppressor- und
Onkogene in humanen Tumoren des zentralen Nervensystems
Current occupation: Postdoctoral fellow, DKFZ Heidelberg
Julia Schliwka, PhD (2006) Charakterisierung onkogener Signalwege in Non-Hodgkin-
Lymphomen über RNAi-vermitteltes Gen-Silencing und Mikro-RNA-Profiling
Current occupation: Company Febit, Heidelberg
Ute Schmidt, PhD (2006) In situ and in vivo localization of mRNA in mammalian nuclei:
the role of speckles in mRNA metabolism and transport and evidence for a perispeckle
nuclear compartment
Current occupation: Postdoctoral fellow, Univ. Montpellier
Frank Mendrzyk, PhD (2006) Pathogenic pathways and prognostic markers in pediatric
central nervous system tumors detected by comprehensive molecular profiling
Current occupation: Roche Pharma, Grenzach
Carsten Sticht, PhD (2005) Genomische Charakterisierung der chromosomalen Region
11q13 und 3q25-q29 in Plattenepithelkarzinomen der Kopf-Hals-Region
Current occupation: Postdoctoral fellow, University of Heidelberg
Jörg Schlingemann, PhD (2005) Entwicklung neuer RNA-Amplifikationstechniken für das
Erstellen von Expressionsprofilen mittels DNA-Microarrays
Current occupation: Postdoctoral fellow, University of Uppsala, Sweden
Martyna Adamowicz, PhD (2005) Expression profiling and fine-mapping of high-level
amplifications on chromosome 5p14 in soft tissue tumours using matrix-CGH
Current occupation: Postdoctoral fellow, University of Cambridge, UK
Lars Hummerich, PhD (2005) Identifizierung von tumorrelevanten Genen epithelialer
Hauttumore mittels Expresisonslanalyse
Current occupation: Roche Diagnostics, Mannheim Ludwigshafen
Andrea Murmann, PhD (2004) Topology of Genes in Mammalian Cell Nuclei with Special
Emphasis on the MLL Gene and its Translocation Partner
Current occupation: Postdoctoral fellow, University of Chicago, USA

Kathalin Fejes Todt, PhD (2004) From histones to chromosomes: in vivo and in vitro
analysis of structural changes caused by linker histone H1, histone acetylation and
histone chaperone NAPI
Current occupation: Postdoctoral fellow, Cold Spring Habor, USA
Felix Kokocinski, PhD (2004) Verarbeitung und funktionelle Analyse von molekularen
Profilen aus Micorarray-Experimenten
Current occupation: Postdoctoral fellow, The Wellcome Trust Sanger Institute,
Cambridge, USA
Sabine Görisch, PhD (2004) Accessibility and Dynamics of nuclear Subcompartments in
Interphase Cells
Current occupation: Industry, Berlin
Markus Scheuermann, PhD (2004) Characterization of nuclear sub-compartments by
analysis of the topology of genes and non-transcribed sequences as well as
ectopically expressed proteins in mammalian cells with different karyotypes
Current occupation: Industry, Neu-Isenburg
Gunnar Wrobel, PhD (2004) Aufbau, Validierung und Verwendung eines cDA-Microarray-
Systems für die Expressionsanalyse humaner Meningiome
Current occupation: self-employed business, Hamburg
Björn Fritz, PhD (2003) Untersuchung transkriptaler und genomischer Aberrationsprofile in
menschlichen Tumoren mit Hilfe von DNA-Mikroarrays
Current occupation: Abbot, Munich
Christian Korz, PhD (2003) Expressionsanalysen zu den Pathomechanismen der
chronisch lymphatischen Leukämie vom B-Zell-Typ und des
Mantelzellenlymphoms
Current occupation: Senior Purchasing Manager, Roche Diagnostics GmbH
Daniel Mertens, PhD (2002) Characterization of candidate tumor suppressor genes in Bcell
chronic lymphocytic leukaemia, University of Tübingen
Current occupation: Juniorgroup leader, University of Ulm
Andreas Rätsch, MD (2002) Untersuchungen zur Toplogie des c_MYC Gens und des
Immunglobulinlocus innerhalb der t(2;8) Translokation bei Burkitt-Lymphom
Zelllinien, University of Heidelberg
Current occupation: Industry, Ingelheim