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Buprenorphine’s Unique Properties<br />
• Partial Agonist/Antagonist: has better safety profile – less<br />
respiratory depression<br />
• Highest affinity for the opioid receptor: will replace a pure<br />
agonist and even antagonist off the receptor<br />
• Long half-life – will bind the receptor for long period –<br />
elimination ½ life is ~ 37 hrs.<br />
• Has no oral bioavailability - its use in opioid dependence is<br />
the
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