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Buprenorphine/Naloxone for the<br />

treatment of pain and opioid<br />

dependence<br />

• Must meet DSM-IV opioid dependence criteria<br />

• No contraindications to treatment<br />

• Follow established guidelines for induction and<br />

maintenance<br />

• Buprenorphine efficacy vs opioid agonist such as morphine<br />

is unclear and probably varies with type of pain. In the<br />

Buprenorphine trainings, we teach that buprenorphine has<br />

analgesia 30 X that of morphine. 11 However, to compare<br />

efficacy is difficult.<br />

• Buprenorphine dosed three to four times daily for control<br />

of pain (versus daily in opioid dependence alone).

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