Joint Annual Research Report 2004 - The Royal Marsden

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SENIOR STAFF & COMMITTEES 2004 Senior Staff & Committees 2004 THE INSTITUTE OF CANCER RESEARCH BOARD OF TRUSTEES Lord Faringdon (Chairman) Dr J M Ashworth MA PhD DSc (Deputy Chairman) Mr E A C Cottrell (Honorary Treasurer) Professor P W J Rigby PhD FMedSci (Chief Executive) Professor R J Ott PhD FInstP CPhys (Academic Dean) Dr R Agarwal (from September 2004) Sir Henry Boyd-Carpenter KCVO MA Dr S E Foden MA DPhil Mrs T M Green MA Mr C Gutierrez (to September 2004) Mr R A Hambro Professor M O Leach PhD FInstP FIPEM CPhys FMedSci Professor A Markham DSc FRCP FRCPath FMedSci Dr T A Hince MSc PhD (Alternate Director) (to September 2004) Dr M J Morgan PhD Professor H R Morris FRS (to March 2004) Miss C A Palmer MSc MHSM DipHSM Dr D Weir-Hughes OStJ MA EdD RN FRSH (Alternate Director) Professor D H Phillips PhD DSc FRCPath Miss A C Pillman OBE Mr R E Spurgeon Professor M Waterfield FRS FMedSci Miss M I Watson MA MBA FCIPD Dr D E V Wilman PhD CChem MRSC ARPS (to October 2004) Mr J M Kipling FCA (Secretary of The Institute and Head of Corporate Services) Professor A Horwich PhD FRCP FRCR FMedSci (Director of Clinical Research and Development and Head of the Clinical Laboratories) Professor C J Marshall DPhil FRS FMedSci (Chairman of the Joint Research Committee) Professor K R Willison PhD (Head of the Chester Beatty and Haddow Laboratories) CORPORATE MANAGEMENT GROUP Professor P W J Rigby PhD FMedSci (Chief Executive – Chairman) Mr J M Kipling FCA (Secretary of The Institute and Head of Corporate Services) Professor A Horwich PhD FRCP FRCR FMedSci (Director of Clinical Research and Development and Head of the Clinical Laboratories) Professor S B Kaye MD FRCP FRCR FRSE FMedSci Professor R J Ott PhD FInstP CPhys (Academic Dean) Professor K R Willison PhD (Head of the Chester Beatty and Haddow Laboratories) Professor P Workman PhD FIBiol FMedSci SECTION CHAIRMEN Chester Beatty Laboratories Professor A Ashworth PhD FMedSci (Director, The Breakthrough Toby Robins Breast Cancer Research Centre) Professor D Barford DPhil FMedSci (Section of Structural Biology) (from November 2004) Professor P W J Rigby PhD FMedSci (Acting Chair of the Section of Gene Function and Regulation) Professor M F Greaves PhD FRCPath FRS FMedSci (Section of Haemato-Oncology) Professor C J Marshall DPhil FRS FMedSci (Section of Cell and Molecular Biology and Director, Cancer Research UK Centre for Cell and Molecular Biology) Professor L H Pearl PhD (Section of Structural Biology) (to November 2004) Clinical Laboratories Ms J M Bliss MSc FRSS (Section of Clinical Trials) (from January 2004) Professor M Dowsett PhD (Academic Department of Biochemistry) Professor A Horwich PhD FRCP FRCR FMedSci (Section of Radiotherapy) Professor J E S Husband OBE FRCP FRCR FMedSci (Co-Director, Cancer Research UK Clinical Magnetic Resonance Research Group) Professor S B Kaye MD FRCP FRCR FRSE FMedSci (Section of Medicine and Cancer Research UK Medical Oncology Unit) Professor M O Leach PhD FInstP FIPEM CPhys FMedSci (Co-Director, Cancer Research UK Clinical Magnetic Resonance Research Group) Professor K Pritchard-Jones PhD FRCPCH FRCPE (Acting Chair of Section of Paediatric Oncology) Professor S Webb PhD DIC DSc ARCS FInstP FIPEM FRSA CPhys (Joint Department of Physics) Haddow Laboratories Professor C S Cooper DSc FMedSci (Section of Molecular Carcinogenesis) Professor M R Stratton PhD MRCPath FMedSci (Section of Cancer Genetics) Professor A J Swerdlow PhD DM DSc FFPH FMedSci (Section of Epidemiology) Professor P Workman PhD FIBiol FMedSci (Section of Cancer Therapeutics and Director, Cancer Research UK Centre for Cancer Therapeutics) JOINT RESEARCH COMMITTEE The Institute and the Royal Marsden Professor C J Marshall DPhil FRS FMedSci (Chairman) Professor A Ashworth PhD FMedSci Professor M E Gore PhD FRCP (to July 2004) Professor M F Greaves PhD FRCPath FRS FMedSci Professor A Horwich PhD FRCP FRCR FMedSci Dr R S Houlston MD PhD FRCP FRCPath Professor J E S Husband OBE FRCP FRCR FMedSci (to July 2004) Dr S R D Johnston MA PhD FRCP (from September 2004) Professor S B Kaye MD FRCP FRCR FRSE FMedSci Dr C Nutting MD MRCP FRCR (from September 2004) Miss C A Palmer MSc MHSM DipHSM Professor P W J Rigby PhD FMedSci Professor I E Smith MD FRCP FRCPE (to July 2004) Professor M R Stratton PhD MRCPath FMedSci Professor K R Willison PhD Professor P Workman PhD FIBiol FMedSci
ACADEMIC BOARD The Institute and the Royal Marsden Professor R J Ott PhD FInstP CPhys (Chairman and Academic Dean) Professor P W J Rigby PhD FMedSci (Chief Executive) Professor A L Jackman PhD (Deputy Dean, Biomedical Sciences) Professor K Pritchard-Jones PhD FRCPCH FRCPE (Deputy Dean, Clinical Sciences) Dr G W Aherne* PhD Dr K Allen PhD Professor A Ashworth PhD FMedSci Dr J C Bamber PhD Professor D Barford DPhil FMedSci Mr D P J Barton MRCOG FRCS Ms J M Bliss* MSc FRSS Professor M Brada FRCP FRCR Dr G J R Cook MD FRCP FRCR Professor C S Cooper DSc FMedSci Professor D Cunningham MD FRCP Professor D P Dearnaley MA MD FRCP FRCR Dr N de Souza* MD FRCP FRCR Professor M Dowsett PhD Dr S A Eccles* PhD Dr R Eeles* PhD FRCP FRCR Dr P M Evans* DPhil MInstP MIMA Dr B Felicetti PhD Professor C Fisher MD DSc(Med) FRCPath Dr G Flux PhD Dr G H Goodwin* PhD Professor M E Gore PhD FRCP Professor M F Greaves PhD FRCPath FRS FMedSci Ms S Hockley Professor A Horwich PhD FRCP FRCR FMedSci Dr R S Houlston* MD PhD FRCP FRCPath Dr R A Huddart PhD MRCP FRCR Dr D Hudson PhD Professor J E S Husband OBE FRCP FRCR FMedSci Professor C Isacke DPhil Professor I R Judson MD FRCP Dr M Katan* PhD Professor S B Kaye MD FRCP FRCR FRSE FMedSci Professor M O Leach PhD FInstP FIPEM CPhys FMedSci Dr W Liu PhD CBiol MIBiol Dr R Marais* PhD Professor C J Marshall DPhil FRS FMedSci Dr E Matutes* MD PhD FRCPath Dr S Mittnacht* PhD Professor G J Morgan PhD FRCP FRCPath Professor P S Mortimer MD FRCP MRCS Dr S M Moss* PhD HonMFPH Dr G Payne DPhil MInstP MIPEM Professor L H Pearl PhD Professor J Peto DSc HonMFPH FIA FMedSci Professor D H Phillips PhD DSc FRCPath Dr S Popat PhD MRCP Mrs J Provin MA PGCEA Professor N Rahman PhD MRCP Mr P H Rhys-Evans DCC LRCP FRCS Dr J M Shipley* PhD Mr H Smith Professor I E Smith MD FRCP FRCPE Dr K Snell* PhD FRSA LRPS Professor C J Springer PhD CChem FRSC Professor M R Stratton PhD MRCPath FMedSci Professor A J Swerdlow PhD DM DSc FFPH FMedSci Dr G R ter Haar* DSc PhD FIPEM FAIUM Dr M Watson PhD DipClinPsychol AFBPS Professor S Webb PhD DIC DSc ARCS FInstP FIPEM FRSA CPhys Dr K M Weston PhD Professor K R Willison PhD Professor P Workman PhD FIBiol FMedSci Mr A C Wotherspoon MRCPath Professor J R Yarnold MRCP FRCR Dr A Z Zelent* MPhil PhD *Reader FACULTY AND HONORARY FACULTY The Institute and the Royal Marsden Dr G W Aherne* PhD Dr M Ashcroft* PhD Professor A Ashworth* PhD FMedSci Dr J C Bamber* PhD Professor D Barford* DPhil FMedSci Ms J M Bliss* MSc FRSS Dr J de Bono PhD FRCP Dr J Boyes* PhD (to November 2004) Professor M Brada* FRCP FRCR Dr L Bruno PhD Dr I Collins* PhD Professor C S Cooper* DSc FMedSci Professor D Cunningham* MD FRCP Dr D R Dance* PhD FInstP FIPEM CPhys Professor D P Dearnaley* MA MD FRCP FRCR Professor M Dowsett* PhD Dr S A Eccles* PhD Dr R A Eeles* PhD FRCP FRCR Dr T G Q Eisen PhD FRCP Dr P M Evans* DPhil FInstP MIMA Professor C Fisher* MD DSc(Med) FRCPath Dr M A Flower* PhD (to September 2004) Dr G Flux* PhD (from January 2004) Dr M D Garrett* PhD Dr G H Goodwin* PhD Professor M E Gore* PhD FRCP Professor M F Greaves* PhD FRCPath FRS FMedSci Dr E Hall PhD Dr K J Harrington MRCP FRCR Professor A Horwich* PhD FRCP FRCR FMedSci Dr R S Houlston* MD PhD FRCP FRCPath Dr R A Huddart* PhD MRCP FRCR Professor J E S Husband* OBE FRCP FRCR FMedSci Professor C Isacke* DPhil Professor A L Jackman* PhD Dr S R D Johnston MA PhD FRCP (from September 2004) Dr C Jones PhD Dr C M Jones* PhD (to August 2004) 67
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ANNUAL RESEARCH REPORT 2004 The Roy
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CONTENTS Review of 2004 - from the
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Cancer genes Scientific Strategy: f
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REVIEW OF 2004 tumours. It is highl
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REVIEW OF 2004 While there have bee
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REVIEW OF 2004 Campaign attracted u
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Academic Dean’s Report 2004 Our a
Page 15 and 16: ACADEMIC DEAN’S REPORT 2004 We ac
Page 17 and 18: Technology Transfer Report 2004 The
Page 19 and 20: TECHNOLOGY TRANSFER Figure 1. The V
Page 21 and 22: differentiated lactating lobules ar
Page 23 and 24: CANCER BIOLOGY SMAC ’em dead It i
Page 25 and 26: Extracellular environment Signal Re
Page 27 and 28: CANCER THERAPEUTICS/CANCER BIOLOGY
Page 29 and 30: Examples of current projects A vari
Page 31 and 32: CANCER THERAPEUTICS No. of patients
Page 33 and 34: CANCER THERAPEUTICS molecular diagn
Page 35 and 36: e very useful. Examples include tha
Page 37 and 38: CANCER THERAPEUTICS Integrating new
Page 39 and 40: The duration of adjuvant chemothera
Page 41 and 42: CANCER THERAPEUTICS Future directio
Page 43 and 44: Figure 1. Superficial spreading mel
Page 45 and 46: CANCER THERAPEUTICS Four randomised
Page 47 and 48: Lung cancer In collaboration with D
Page 49 and 50: IMAGING RESEARCH & CANCER DIAGNOSIS
Page 51 and 52: (a) (b) Figure 1. Whole mount betag
Page 53 and 54: CANCER BIOLOGY/RADIOTHERAPY metasta
Page 55 and 56: It is likely that the causes of eac
Page 57 and 58: HEALTH RESEARCH The Breakthrough Ge
Page 59 and 60: elative risk of developing breast c
Page 61 and 62: HEALTH RESEARCH Accordingly, in our
Page 63 and 64: In addition to browsing lists of re
Page 65: MOLECULAR PATHOLOGY Section of Haem
Page 69 and 70: SENIOR STAFF & COMMITTEES 2004 MEDI
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