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96 ABSTRACT #P-L3 IS ZONA PELLUCIDA THICKNESS AN INDICATOR OF EMBRYO IMPLANTATION POTENTIAL Siamak Bashar [O], Gelareh Motamedi, Agata Sojecki, Rodica Mandel, Hanna Balakier, and Clifford Librach CReATe Fertility Center, Department of Obstetrics and Gynaecology, Sunnybrook Health Sciences Centre and Women’s College Hospital, University of Toronto. Objective: Zona pellucida thickness (ZT) and the process of gradual zona thinning have been suggested to be the most predictive indicators for the implantation potential of transferred embryos. However, little is known about the intrinsic and external factors that regulate the thinning process of human zona pellucidae. The objective of our study was to evaluate whether zona pellucida thickness on day 3 of in vitro culture is correlated with maternal (patient) age, embryo quality, Day 3 FSH, peak estradiol (E2) levels, implantation rate and pregnancy outcome. Methods: After obtaining REB approval, data on zona thickness and patient clinical parameters was collected from 360 patients of all ages undergoing IVF or ICSI procedures. Zona pellucida measurements were performed on all Day 3 embryos (n = 2396) derived from normal zygotes (normally fertilized oocytes). Zona thickness was classified into 6 categories according to an ascending range of mean values from 9.0 µm to >=19.1 µm. Results: No significant correlation was observed between zona thickness and the age of the patients (P=0.654; Table 1). The overall mean zona thickness was 15.97±2.53 µm and the embryos with very thin zona pellucida were rare in all age groups. 59 out of 2396 (2.5%) embryos had a zona thickness in the range of 9.0µm to11.0 µm and 8% of embryos had zona thickness in the range 11.1 and 13.0µ (212/2396). The majority of embryos ranged between 15.1-19.0 µm (54.5%). No significant relationship was observed between zona thickness and the maximum E2 value on the day of HCG administration. The proportion of embryos in the six categories of mean zona thickness was similar regardless of E2 level (P=0.2561). There was also no association between zona thickness and FSH values on Day 3 of the cycle prior (P-0.3824). A very significant association was found between zona thickness and individual embryo quality (P=0.0005). Embryos with no or minimal number of cytoplasmic fragments (0-10%) and equal cell size (G1- G2; n=1967) had significantly thinner zonae (Av. 15.87µ±2.48) compared with the embryos containing more fragments and uneven blastomeres (G3 = 16.36µ±2.57 and G4-G5 = 16.59µ±3.06). A total of 137 clinical pregnancies resulted from 360 embryo transfer cycles (38.1%). Comparison of zona thickness of all transferred embryos between pregnant versus nonpregnant patients showed no significant differences (15.96 versus 16.97; P =0.5002). Conclusions: The thickness of the human zona pellucida is not influenced by intrinsic and external factors such as patient age, day 3 FSH or peak E2 levels. Zona thickness is highly correlated with embryo quality. It appears that overall zona thickness is not correlated with pregnancy rate, suggesting that embryo hatching depends more on inherent properties of gametes and the developmental potential of the resultant fertilized embryos.
97 ABSTRACT #P-L4* DAB2 MEDIATES GLUCOCORTICOID RECEPTOR SIGNALING IN EPITHELIAL OVARIAN CANCER CELLS. Alicia Tone [G] (1-4), Carl Virtanen (5), Patricia Shaw (2-4) and Theodore J. Brown (1,3). (1)The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Departments of (2)Laboratory Medicine and Pathobiology, and (3)Obstetrics and Gynaecology, University of Toronto, and (4)Department of Pathology, and the (5)Microarray Center, University Health Network. *Abstract available in hardcopy version only.
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Department of Obstetrics and Gynaec
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2 PROGRAMME-AT-A-GLANCE (A.M.) 7:30
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5 PROGRAMME 26TH ANNUAL RESEARCH DA
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7 P-A4 PHENOTYPE OF EARLY ONSET INT
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9 P-C2 ESTROGEN EXTRACTION FROM MIC
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11 P-E4 LAPAROSCOPIC PERITONEAL ENT
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13 12:05 - 1:05 p.m. LUNCH [Dining
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15 P-G2 P16 ONCOPROTEIN AS A TRIAGE
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17 GROUP I: Chairs/Judges: Drs. Jon
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19 GROUP K: Chairs/Judges: Drs. Gra
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21 4:15 - 5:15 p.m. Henderson Lectu
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23 AWARDS The Papsin Award The Dr.
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26 ABSTRACT #O1* CO-ENZYME Q10 SUPP
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28 ABSTRACT #O3* VEPH1 IS A NOVEL R
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30 ABSTRACT #O5* TISSUE SPECIFIC TR
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32 ABSTRACT #O7 JOB SATISFACTION AM
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34 ABSTRACT #O9 ABDOMINAL VISCERAL
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36 ABSTRACT #O11 REGULATORY EFFECTS
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38 ABSTRACT #O13 THE EFFECT OF CHRO
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POSTER ABSTRACTS 40
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42 ABSTRACT #P-A2 INCREASED MATERNA
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44 ABSTRACT #P-A4 PHENOTYPE OF EARL
Page 48 and 49: 46 ABSTRACT #P-B1* ANGIOGENIC CD56
Page 50 and 51: 48 ABSTRACT #P-B3 UNDERSTANDING THE
Page 52 and 53: 50 ABSTRACT #P-B5 LOW VITAMIN D LEV
Page 54 and 55: 52 ABSTRACT #P-C2* ESTROGEN EXTRACT
Page 56 and 57: 54 ABSTRACT #P-C4 PRETERM PERMATURE
Page 58 and 59: 56 ABSTRACT #P-D2 CRYOPRESERVATION
Page 60 and 61: 58 ABSTRACT #P-D4 DIFFERENTIAL EXPR
Page 62 and 63: 60 ABSTRACT #P-E1 THE ROLE OF ANDRO
Page 64 and 65: 62 ABSTRACT #P-E3 CELL CYCLE INHIBI
Page 66 and 67: 64 ABSTRACT #P-F1 DEXAMETHASONE STI
Page 68 and 69: 66 ABSTRACT #P-F3 EDUCATING SURGICA
Page 70 and 71: 68 ABSTRACT #P-F5 OUTCOMES IN ROBOT
Page 72 and 73: 70 ABSTRACT #P-G2 P16 ONCOPROTEIN A
Page 74 and 75: 72 ABSTRACT #P-G4 ALTERED ADRENOCOR
Page 76 and 77: 74 ABSTRACT #P-H1 RETINAL HEMORRHAG
Page 78 and 79: 76 ABSTRACT #P-H3 A ROLE FOR MCL-1
Page 80 and 81: 78 ABSTRACT #P-H5 A NOVEL ROLE FOR
Page 82 and 83: 80 ABSTRACT #P-I2 THE TIMING OF DEL
Page 84 and 85: 82 ABSTRACT #P-I4 OMEGA-3 FATTY ACI
Page 86 and 87: 84 ABSTRACT #P-J1* WHAT IS KEEPING
Page 88 and 89: 86 ABSTRACT #P-J3 HUMAN EMBRYONIC F
Page 90 and 91: 88 ABSTRACT #P-J5 BARRIERS TO COMPL
Page 92 and 93: 90 ABSTRACT #P-K2 THE “DUC” TRI
Page 94 and 95: 92 ABSTRACT #P-K4 IS THERE A ROLE F
Page 96 and 97: 94 ABSTRACT #P-L1 EXPRESSION AND RE
Page 100 and 101: 98 ABSTRACT #P-L5 SPECTRUM OF VASCU
Page 102 and 103: 100 Presenters by Last Name cont’
Page 104 and 105: 102 Presenters by Abstract # and Se
Page 106 and 107: 104 Presenters by Abstract # and Se
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