Inflammatory Bowel Diseases and Multiple Sclerosis
Inflammatory Bowel Diseases and Multiple Sclerosis
Inflammatory Bowel Diseases and Multiple Sclerosis
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GýíBoüùBÿ AèPùBGþ oôkû ìþ|OõAðñl GB uñloï|øBÿ οHþ ìhPé×þ øípAøþ kAyPú GByñl. AgýpA« ko ìÇBèÏBOþ Gpôq øírìBó GýíBoüùBÿ AèPùBGþ oôkû ô<br />
|âõAo}, 3831|; uBë ðùî:| 09|-881<br />
øírìBðþ GýíBoüùBÿ AèPùBGþ oôkû ô GýíBoÿ ìõèPýLê Außépôq:<br />
ìÏpÖþ kô GýíBo<br />
kÞPp ðB¾p AGpAøýíþ koüBðþ1* , kÞPp ìpüî OBWýà 2 , kÞPpìdíl GzByPþ 2 , kÞPp GBGà cÜ KñBû 2<br />
1 AuPBk, Gh{ âõAo}, GýíBouPBó AìBï gíýñþ, kAðzãBû Îéõï Kryßþ OùpAó<br />
2<br />
Ktôøzãp, GýíBouPBó AìBï gíýñþ, kAðzãBû Îéõï Kryßþ OùpAó<br />
ìõèPýLê Außépôq ko OÏlAkÿ Aq GýíBoAó ârAo} ylû AuQ. Gpôq ÎçDî ô ðzBðú|øBÿ üßþ Aq Aüò k ô GýíBoÿ ko GýíBoAó ìHPç Gú GýíBoÿ küãp GBül Âíò<br />
GpAðãýhPò yà GBèýñþ ìPh¿¿ýò, ko ¾õoR èrôï GB AðXBï AÚlAìBR Ozhý¿þ ðýr øípAû GByl.<br />
ko Aüò ârAo}, Gú ìÏpÖþ k ô GýíBo ìHPç Gú GýíBoüùBÿ AèPùBGþ oôkû, Þú Gú|Æõo øírìBó Gú GýíBoÿ ìõèPýLê Außépôq ðýr ìHPç Gõkðl, KpkAgPú ylû<br />
AuQ. âõAo}, 3831; uBë ðùî: 09-881<br />
ôAsû|øBÿ Þéýlÿ: GýíBoüùBÿ AèPùBGþ oôkû, ÞõèýQ qgíþ, ìõèPýLê Außépôq<br />
ÞBø{ GýñBüþ ðlAyPú AuQ. GýíBo WùQ AoqüBGþ GýzPp ko GýíBouPBó<br />
GvPpÿ |yl. ko Aï|@o|@ÿ AðXBï ylû, KçÞùBÿ ìPÏlkÿ ko ìBkû u×ýl<br />
ìÛlìú<br />
GýíBoüùBÿ AèPùBGþ oôkû GB ^ñlüò uñloï οHþ øípAøþ kAoðl Þú<br />
ðõAcþ ìXBôo GÇñþ ô uíþ|AôôAë uñPpôï ô Wõk kAyQ (yßê 1). ko<br />
ìBüÐ ìÓrÿ- ðhBÎþ yBgÀ |GgI |GýzPp Aq 7/0 Gõk, ôèþ AèýãõÞéõ ðBë<br />
Aq Wíéú @ðùB GýíBoÿ ìõèPýLê Außépôq AuQ. ko^ñlüò ìÇBèÏú ðzBó<br />
kAkû ylû AuQ Þú ìýrAó Gpôq GýíBoÿ ìõèPýLê Außépôq ko GýíBoAó<br />
GBðl AÖrAü{ ðlAyQ. GýíBo GB OzhýÀ ìõèPýLê Außépôq<br />
|)sisorelcs elpitlum etinifed yllacinilc( |OdQ koìBó GB KBèw<br />
ìHPç Gú GýíBoüùBÿ AèPùBGþ oôkû GýzPp Aq WíÏýQ WBìÏú AuQ(7-1) .<br />
koÆþ kû uBë, Aq ìýBó 264 GýíBo ìHPç Gú GýíBoüùBÿ AèPùBGþ oôkû<br />
ÞõoOýßõuPpôDýl Gú ìlR üà ø×Pú ÚpAo âpÖQ ô GÏl Aq @ó GpAÿ GýíBo<br />
Kpkðýrôèõó gõoAÞþ (06 ìýéþ|âpï oôqAðú) @ÒBq yl. Kpkðýrôèõó Gú<br />
(604 |ìõok ÞõèýQ qgíþ ô 65 ìõok Þpôó) ìpAWÏú|Þññlû Gú koìBðãBû<br />
ìB, 2 GýíBo Gú|Æõo øírìBó GýíBoÿ ìõèPýLê Außépôq ðýr kAyPñl. ko<br />
Aüò ârAo} Gú ìÏpÖþ Aüò k ô GýíBo KpkAgPú gõAøl yl.<br />
ìÏpÖþ GýíBoAó<br />
GýíBo Aôë @ÚBÿ 42 uBèú, Aøê OùpAó ô kAðzXõ AuQ Þú ÎçDî ôÿ<br />
kouBë 8731 Gú|¾õoR Îlï øíBøñãþ ÎÃçR kooAû oÖPò (@OBÞvþ)<br />
@ÒBq yl. GýíBo yp f cBèþ Aq ÞpgPþ ô Gþ|cvþ AðlAìùB, k ô Gýñþ ô<br />
*<br />
ðõüvñlû ìvEõë: kÞPp ðB¾p AGpAøýíþ koüBðþ- OùpAó, GéõAo ÞzBôoq,<br />
GýíBouPBó AìBï gíýñþ, Gh{ âõAo}<br />
E-mail: nebrahim@sina.tums.ac.ir<br />
Oé×ò: 6 4 4 9 9 78 8 | ðíBGp: 0 48 9 9 78 8 yßê 1|: Aï|@o|@ÿ ìÓr GýíBo Aôë Þú ko@ó KçÞùBÿ ìPÏlk ko ìBkû u×ýl ðõAcþ<br />
ìXBôo GÇñþ ô uíþ|AôôAë uñPpôï ìzBølû ìþ|yõk.<br />
âõAo} / uBë ðùî / yíBoû 3 / KBüýr 3831<br />
188
ìÇp f Þññlû ÞõèýQ qgíþ Gõk. GpAÿ GýíBo Kpkðýrôèõó gõoAÞþ 04<br />
ìýéþ|âpï oôqAðú ô uõè×BuBæqüò gõoAÞþ 0003 ìýéþ|âpï oôqAðú OXõür<br />
Þõèõ ðõußõKþ AðXBï ylû AèPùBJ ko upAup Þõèõó (KBó|ÞõèýQ)<br />
øípAû GB qgíùBÿ uÇdþ ìPÏlk ô Wõk kAyQ. WõAJ GýõKvþ<br />
ìBû AkAìú KýlA Þpk. ko @qìBü{ ìlÖõÑ gõó ìh×þ ìzBølû âpkül.<br />
ðPBüY âBuPpôußõKþ ô OpAðrüQ oôkû GBoüà ÆHýÏþ Gõk; ôèþ ko<br />
ÎpÅ üà ìBû ÚÇÐ yl. üà ìBû GÏl ôÿ k^Bo AuùBë (3-2 GBo ko oôq)<br />
yl. GýíBo kÖÐ GéÓî, kë|k|ok ô AuùBë yHBðú ðlAyQ. ÎçDî clôk uú<br />
koìBó GB KBèw ÞõoOýßõuPpôDýl Gú ìlR üà ø×Pú ô uLw ÚpÁ<br />
Kpkðýrôèõó 04 ìýéþ|âpï oôqAðú ÚpAo âpÖQ. Kpkðýrôèõó Gú|OloüY ô ko<br />
ìþ|kAk. ènA GýíBo GB OzhýÀ ìõèPýLê Außépôq |<br />
)sisorelcs elpitlum etinifed detroppus yrotarobal( |OdQ<br />
AôèýãõÞéõ ðBë GBðl |1<br />
)BCO( |ìBüÐ ðhBÑ GýíBo ðýr AÖrAü{ ðzBó<br />
AuQ. koAï|@o|@ÿ AðXBï ylû KçÞùBÿ ìPÏlk koìBkû u×ýl ðõAcþ ìXBôo<br />
GÇñþ ô AKPýà ÞýBuíB oôüQ yl )IRM evitisop ecaps(|. øí`ñýò<br />
GýíBok ôï gBðíþ AuQ 32 uBèú, Aøê OùpAó ô kAðzXõÞú kouBë 1831<br />
Gú kðHBë ÞBø{ GýñBüþ GpAÿ ôÿ OzhýÀ ðõoüQ AKPýà ìÇp f ylû<br />
ÚpÁ @uBÞõë 0042 ìýéþ|âpï ko oôq ko ìpcéú gBìõyþ |<br />
)noissimer( |AuQ.<br />
@ÒBq yl. Kpkðýrôèõó Gú|OloüY ô ko ÎpÅ uú ìBû ÚÇÐ yl. ko cBë<br />
cBÂp, Kw Aq ânyQ üà uBë Aq OzhýÀ GýíBoÿ Þpôó GB ì¿pÙ<br />
)sitiloc s'nhorc( |Gõk. GB øíýò OzhýÀ koìBó gõoAÞþ GB<br />
Kpkðýrôèõó 01 ìýéþ|âpï oôqAðú ô ÚpÁ @uBÞõë 0042 ìýéþ|âpï ko oôq<br />
^zî ìþ|gõok Þú ko ÖõA¾ê @ðùB ìhBÉ uBèî )aera piks( ôWõk<br />
kAyQ||. WõAJ GýõKvþ ìÇp f Þññlû ÞõèýQ Þpô ðþ |<br />
k ôoìÛÏlÿ ô oÞPõï ÆHýÏþ Gõk; ôèþ koðBcýú uýãíõ Dýl AèPùBJ ylül<br />
ô qgíùBÿ ìPÏlk ô Wõk kAyQ. ÂBüÏBR ìzBGùþ ko upAup Þõèõó Gú<br />
ôqó Gú ìýrAó 8 Þýéõâpï yl. WùQ Gpouþ GýzPp GpAÿ GýíBo<br />
Þõèõ ðõußõKþ AðXBï yl. ko Þõèõ ðõußõKþ AðXBï ylû ðõAcþ<br />
oôqAðú) ÚpAo âpÖQ. Îç|Dî GýíBo GùHõk ðvHþ KýlA Þpk; ôèþ GB ylOþ<br />
ÞíPp OB KñY ìBû AkAìú üBÖQ ô GýíBo ko ÎpÅ Aüò ìlR, k^Bo ÞBø{<br />
gõ ðþ (01-8 GBo kÖÐ ìlÖõÑ ko oôq) ô qôoKýa âpkül ô GB OzhýÀ<br />
uBèíõ ðéõq OdQ koìBó GB ÚpÁ uýLpô ÖéõÞvBuýò (0001 ìýéþ|âpï<br />
ìpcéú GýíBo OdQ koìBó GB AüñPpÖpôó |)xenovA( |ÚpAo âpÖQ. ^ùBo<br />
uBë GÏl Aq OzhýÀ ìõèPýLê Außépôq, ôÿ k^Bo kë|kok, AuùBë<br />
OloüY ko ÎpÅ üà ìBû ô ðýî ÚÇÐ âpkül ô ÎçDî GýíBo GùHõk üBÖQ.<br />
GýíBo ko Æþ k ô uBë GÏl, 2 GBo küãp k^Bo cíéú @OBÞvþ yl. ko Aüò<br />
GýíBoüùBÿ AèPùBGþ oôkû ô ìõèPýLê Außépôq<br />
âõAo} / uBë ðùî / yíBoû 3 / KBüýr 3831<br />
ìÇBèÏBR Gú Îíê @ìlû ðzBó kAkû|Aðl Þú uýp GýíBoÿ ìõèPýLê<br />
ÎçDî GýíBoüùBÿ AèPùBGþ oôkû @ÒBq ylû Gõk Þú GB üBÖPú|øBÿ ìõWõk ko<br />
ìÇBèÏBR ÚHéþ øíhõAðþ kAyQ(5-3) .<br />
kAkû ylû Gõk(5-3)<br />
AyBoû Þpk(8)<br />
. ko GýíBoAó ìB ðýr ÎçDî ìõèPýLê Außépôq ÚHê Aq<br />
KpkAgPú|Aðl. AÞTp Aüò GýíBoAó (3 GýíBo) gBðíùBüþ Gõkðl Þú GýíBoÿ<br />
ìõèPýLê Außépôq@ðùB 8-5 uBë ÚHê Aq ypôÑ GýíBoÿ Þpôó OzhýÀ<br />
Gp AuBx WvQ|ô|Wõÿ ìÛBæR, ^ùBo ârAo} küãp Gú ìÏpÖþ 4<br />
GýíBo Þú øírìBó GýíBoüùBÿ AèPùBGþ oôkû ô ìõèPýLê Außépôq kAyPñl<br />
ôèþ Aüò ìÛlAo ðíþ|OõAðl GýBðãp yýõÑ ôAÚÏþ ìõèPýLê Außépôq ko<br />
ìHPçüBó Gú GýíBoüùBÿ AèPùBGþ oôkû|Aÿ ko WBìÏú ìB GByl.<br />
oôkû Þú ko koìBðãBû ìB ko Æõë kû uBë OdQ Kýãýpÿ ô koìBó ÚpAo<br />
âpÖPñl, ÖpAôAðþ ìõèPýLê Außépôq clôk 4/0 ko¾l Gú kuQ @ìl.<br />
oôkû oA yBìê ìþ|ylðl(2) . |ko ìýBó ìHPçüBó Gú GýíBoüùBÿ AèPùBGþ<br />
AèPùBGþ<br />
GýíBoüùBÿ Gú ìHPç GýíBoAó ko¾l 8/0 Þú kAyPñl ðýr Außépôq<br />
küãpÿ Aq @ìpüßB Aq Gýò 474 GýíBo ìHPç Gú GýíBoüùBÿ AèPùBGþ oôkû<br />
ìpAWÏú |Þññlû Gú üà koìBðãBû, ^ùBo GýíBo Gú|Æõo øírìBó ìõèPýLê<br />
(000001/5) O×BôR ÚBGê ìçcËú|Aÿ kAyPú AuQ(1)<br />
uBèýBðú ìõèPýLê Außépôq ko GýíBoAó ìHPç Gú GýíBoüùBÿ AèPùBGþ oôkû<br />
GpAGp GB 000001/81 Gp@ôok ylû Þú ðvHQ Gú WíÏýQ ÎBkÿ AðãévPBó<br />
ko ìõok Gpôq øírìBó GýíBoüùBÿ AèPùBGþ oôkû ô ìõèPýLê Außépôq<br />
@ìBo kÚýÛþ ko kuQ ðývQ. Gp AuBx ìÇBèÏú|Aÿ ko AðãévPBó Gpôq<br />
øípAû Gõkó GýíBoüùBÿ AèPùBGþ oôkû GB ìõèPýLê Außépôq AyBoû ylû<br />
AuQ|(5-1ô 9) .<br />
. øí`ñýò ârAoyùBÿ ìPÏlkÿ ô Wõk kAoðl Þú ko@ðùB Gú<br />
ylû|Aðl. Aq Wíéú Aüò OËBøpAR ìþ|OõAó Gú cõAkV ÎpôÚþ ìÓr,<br />
ìýéõKBOþ|øB, ðõoôKBOþ|øBÿ ìdýÇþ, ìýõKBOþ|øB ô ìýBuPñþ âpAôüw<br />
GdU<br />
OËBøpAR οHþ ìPÏlkÿ ko AoOHBÉ GB GýíBoüùBÿ AèPùBGþ oôkû mÞp<br />
ô Aüò GýíBoÿ ðýr ko ìpcéú gBìõyþ AuQ.<br />
. Gp AuBx @ìBo<br />
ko ìpcéú gBìõyþ AuQ. øî|AÞñõó koìBó ìõèPýLê Außépôq GB<br />
AüñPpÖpôó (|fibeR|, üà |oôq koìýBó ô Gú ¾õoR qüpWélÿ) AkAìú kAok<br />
oôqAðú ô @qAOýõKpüò 001 ìýéþ|âpï oôqAðú AkAìú üBÖQ. ko cBë cBÂp,<br />
Kw Aq ânyQ clôk k ô uBë Aq ypôÑ ÎçDî ÞõèýQ qgíþ, GýíBoÿ<br />
yl. GÏl Aq clôk uú ìBû, ÎçDî GýíBo GùHõk ÚBGê OõWùþ KýlA Þpk ô<br />
koìBó ðãùlAoðlû Gú|¾õoR uõè×BuBæqüò gõoAÞþ 0003 ìýéþ|âpï<br />
1. oligoclonal b<strong>and</strong>ing<br />
189
ìpAWÐ<br />
âõAo} / uBë ðùî / yíBoû 3 / KBüýr 3831<br />
Aq@ðñl Þú AuP×Bkû Aq kAoôøBÿ Âl ||a|-FNT |(ìBðñl |bamixilfni|) ko<br />
OõWýú oôAGÈ ìõWõk ko kuQ ðývQ(11 ,01). |Aq ÆpÖþ ârAoyùB cBÞþ<br />
WùQ<br />
ÞBÖþ AÆçÎBR AìB Þpk. AyBoû gõkAüíñþ AgPçæR GB @ðùB<br />
Aüò k ô GýíBoÿ, Aq ðËp ÎõAìê qìýñú|Aÿ, kAoAÿ ô Wõû ìzPpÞþ<br />
ìþ|GByñl Þú Aq Wíéú @ðùB ìþ|OõAó Gú OõqüÐ ðtAkÿ, uñþ ô øípAøþ<br />
GýíBoAó ìB uBGÛú gBðõAkâþ ìõèPýLê Außépôq ô GýíBoüùBÿ AèPùBGþ<br />
oôkû oA mÞp ðíþ|Þpkðl.<br />
AuPÏlAk Gú GýíBoÿ ìõèPýLê Außépôq ðÛzþ ðlAoðl(7) . øýa|üà Aq<br />
AÖrAü{<br />
|ko |)2DON( Þpôó GýíBoÿ ko ìvEõë sðùBÿ Þú yl külû<br />
Îéþ|oÒî Aüñßú uBèùB ÚHê, AoOHBÉ gBðõAkâþ Gýò GýíBoüùBÿ<br />
AèPùBGþ oôkû ô ìõèPýLê Außépôq ìõok OõWú ÚpAo âpÖQ(6) , GÏløB<br />
GýíBoüùBÿ AèPùBGþ oôkû ðýr ko øp k ô GýíBo Gú|gõGþ Gú koìBó KBui<br />
kAkðl.<br />
ÖpôÞ{ )gnittimer dna gnispaler( |øípAû Gõk. øýa|ÞlAï Aq<br />
GýíBoAó ðBOõAðBüýùBÿ οHþ øípAû ðlAyPñl. ÎçDî ìpGõÉ Gú<br />
gõGþ kAok(2) . uýp GýíBoÿ ìõèPýLê Außépôq ko øpk ô GýíBo ìB GB Îõk ô<br />
@âùþ<br />
Ký{ oôkû AèPùBGþ GýíBoüùBÿ Gú ìHPç GýíBoAó ko Außépôq<br />
kÞPp AGpAøýíþ koüBðþ ô øíßBoAó<br />
ìPh¿¿ýò ÚpAoâýpk(9,1) .<br />
Außépôq ô øí`ñýò øñãBï Gpôq ÎçDî âõAoyþ-oôkû|Aÿ ìrìò ko<br />
ìHPçüBó Gú ìõèPýLê Außépôq, GpouýùBÿ KBoAÞéýñýßþ ìõok ðËp<br />
GB OõWú Gú ìÇBèI ÖõÝ, Aüò ðßPú cBDr AøíýQ AuQ Þú ko uýp<br />
GBèýñþ GýíBoüùBÿ AèPùBGþ oôkû, ÎçDî οHþ ìÇp f|Þññlû ìõèPýLê<br />
|AuP×Bkû ðíþ|Þpkðl; ÖpÂýú Aôë Þú ko ðùBüQ GýBðãp oAGÇú GýíBoüùBÿ<br />
AèPùBGþ oôkû ô ìõèPýLê AußépôqAuQ GýzPpìþ|OõAðl ìõok OõWú ÚpAoâýpk.<br />
ìvPÛýî ì¿pÙ Aüò kAoôøB kAðvQ. cBë, GB OõWú Gú Aüñßú AÞTpüQ<br />
GýíBoAó ârAo} ylû ko ìÛBæR ìhPéØ Aq kAoôøBÿ Âl |a|-FNT<br />
ìþ|OõAðl Gú ôAuÇú ì¿pÙ kAoôøBüþ øí`õó |bamixilfni |AÖrAü{<br />
üBGl. Gp AuBx ÖpÂýú k ôï ìõèPýLê Außépôq oA ìþ|OõAó ÎBoÂú<br />
Gú Aüò ìvEéú ìþ|OõAó k ô ÖpÂýú ìP×BôR oA ìÇp f Þpk: GpAuBx ÖpÂýú<br />
Aôë Gpôq ìõèPýLê Außépôq ko ìHPçüBó Gú GýíBoüùBÿ AèPùBGþ oôkû<br />
ìõèPýLê Außépôq ðýr kAoðl, Aq Aüò kAoôøB AuP×Bkû ðzõk(31) . GB OõWú<br />
øírìBó<br />
Þú oôkû AèPùBGþ GýíBoüùBÿ Gú ìHPç GýíBoAó ko AuQ ylû<br />
kìýéýñýrAó yHýú Gú ìõèPýLê Außépôq yõk(21) . Gú øíýò kèýê Oõ¾ýú<br />
AèPùBGBR<br />
Gpôq Gú ìñXp ìþ|OõAðl oôkû AèPùBGþ GýíBoüùBÿ Gú ìHPçüBó<br />
1. Rang EH, Brooke BN, Hermon-taylor J. Association of<br />
ulcerative colitis with multiuple sclerosis[letter]. lancet<br />
1982; 2: 555.<br />
2. Keiko K, Hunter SF, Thol<strong>and</strong>er MS et al. Concurrence of<br />
inflammatory bowel disease <strong>and</strong> multiple sclerosis. Mayo<br />
Clin Proc 2000; 75: 802-6.<br />
3. Kitchin LI, Knobler RL, Friedman LS. Crohn's disease in a<br />
patient with multiple sclerosis. J Clin Gastroenterol 1991;<br />
13: 331-4.<br />
4. Bussino GP, Corrente G, visiniti D. Crohn's disease <strong>and</strong><br />
multiple sclerosis: a single case report. Ital J Neurol Sci<br />
1994; 15: 303-6.<br />
5. Agranoff D, schon F. Are focal white matter lesions in<br />
patients with inflammatory bowel disease linked to multiple<br />
sclerosis [letter]. Lancet 1995; 346: 190-1.<br />
6. Minuk GY, Lewkonia RM. Possible familial association of<br />
multiple sclerosis <strong>and</strong> inflammatory bowel disease[letter]. N<br />
Eng J Med 1986; 314: 586.<br />
7. Sawcer S, Maranian M, Hensiek A et al. Crohn's associated<br />
NOD2 gene variants are not involved in determining susceptibility<br />
to multiple sclerosis. J Neurol Neurosurg Psychiatry<br />
2003; 74: 1157.<br />
8. Lossos A, River Y, Eliamkim A et al. Neurological aspects of<br />
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190
<strong>Inflammatory</strong> <strong>Bowel</strong> <strong>Diseases</strong> <strong>and</strong> <strong>Multiple</strong> <strong>Sclerosis</strong><br />
Ebrahimi Daryani N<br />
Department of<br />
Gastroenterolgoy, Imam<br />
Khomeini Hospital, Tehran<br />
University of Medical Sciences<br />
Tajik M<br />
Department of<br />
Gastroenterolgoy, Imam<br />
Khomeini Hospital, Tehran<br />
University of Medical Sciences<br />
Bashashati M<br />
Department of<br />
Gastroenterolgoy, Imam<br />
Khomeini Hospital, Tehran<br />
University of Medical Sciences<br />
Haghpanah B<br />
Department of<br />
Gastroenterolgoy, Imam<br />
Khomeini Hospital, Tehran<br />
University of Medical Sciences<br />
ABSTRACT<br />
<strong>Inflammatory</strong> <strong>Bowel</strong> <strong>Diseases</strong> <strong>and</strong><br />
<strong>Multiple</strong> <strong>Sclerosis</strong>:<br />
A Look on Two Cases<br />
The <strong>Inflammatory</strong> bowel diseases (IBD) have been found to<br />
accompany some neurological syndromes including multiple sclerosis<br />
(MS). Recently, Several studies have reported <strong>and</strong> discussed the<br />
simultaneous presence of IBD <strong>and</strong> MS in some patients. Thus, in patients<br />
with either disease, the presence of signs <strong>and</strong> symptoms of the other<br />
should raise the clinical suspicion of the clinician <strong>and</strong> warrant special<br />
considerations.<br />
In this report, we introduce two IBD patients who have concomitant<br />
involvement of MS. Govaresh 2004; 9: 188-90<br />
Keywords: <strong>Inflammatory</strong> bowel diseases, Ulcerative colitis, <strong>Multiple</strong><br />
sclerosis<br />
Corresponding Author:<br />
Nasser Ebrahimi Daryani MD,<br />
Department of Gastroenterology,<br />
Imam Khomeini Hospital,<br />
Keshavarz Blvd, Tehran, Iran.<br />
Tel: +98 21 88799446<br />
Fax: +98 21 88799840<br />
E-mail:<br />
nebrahim@sina.tums.ac.ir<br />
Govaresh\ Vol. 9\ No. 3\ Autumn 2004 214