Prediction of individual antibiotic dose in the clinic - WorldPharma ...
Prediction of individual antibiotic dose in the clinic - WorldPharma ...
Prediction of individual antibiotic dose in the clinic - WorldPharma ...
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Pharmacok<strong>in</strong>etics <strong>of</strong><br />
benzylpenicill<strong>in</strong><br />
• 3g gives a concentration after 4 h <strong>of</strong> 4 mg/l<br />
• Prote<strong>in</strong>b<strong>in</strong>dn<strong>in</strong>g= 65%.<br />
• Free concentration 1-1.4 mg/l after 4 h<br />
• Half-life= 45 m<strong>in</strong>.<br />
• After 4.45= 0.5 mg/l<br />
• After 5.5 h= 0.25 mg/l<br />
• 3x5.5 h=17.5/24= 69% T>MIC
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