Prediction of individual antibiotic dose in the clinic - WorldPharma ...

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Pharmacokinetics of cloxacillin • Cmax after a 30 min infusion=100 mg/l (2g) Free concentration=6 mg/l • Proteinbindning= 94% • T1/2=30 min • After 2 h conc= 0.35 mg/l • 2h x 3=6/24= 25% T>MIC!
Dosing T>MIC; MIC=0.25 mg/L 2g x 3 25% 2g x 4 33% 2g x 6 50% 3g x 4 42% 3g x 6 63%
Page 1: Prediction of individual antibiotic
Page 4 and 5: Concentration dependent killing of
Page 6 and 7: Intergration between pharmacokineti
Page 8 and 9: ß-lactam antibiotics • Efficacy
Page 10 and 11: Quiolones och aminoglycosids • Ef
Page 12 and 13: Depends on • How long has the pat
Page 14 and 15: Relationship Between Time Above MIC
Page 16 and 17: www.eucast.org
Page 18 and 19: MIC MIC-gränser breakpoints • Ph
Page 20 and 21: Dosing T>MIC; MIC=0.03 mg/L T>MIC;
Page 26 and 27: Piperacillin/tazobactam Spectrum MI
Page 28 and 29: S I R
Page 30: Dosing T>MIC; MIC=1 mg/L T>MIC; MIC
Page 33 and 34: MIC MIC-gränser breakpoints • Ph
Page 35: Dosing T>MIC; MIC=0.03 mg/ L T>MIC;

Prediction of individual antibiotic dose in the clinic - WorldPharma ...

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