Liberation from Mechanical Ventilation E. Wesley Ely, MD, MPH

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Girard TD, et al. Lancet 2008;371:126-34
ABC Trial – Objectives • To determine the efficacy and safety of a protocol combining spontaneous daily interruption awakenings of sedatives trials and (SATs) and spontaneous breathing trials (SBTs) • Ventilator-free days • ICU and hospital length of stay • Survival • Duration of coma and delirium • Long-term neuropsychological outcomes
Page 1 and 2: Wake Up and Breathe: Liberation and
Page 3 and 4: Pain Lack of sleep Difficulty breat
Page 5 and 6: % Neurocognitive Sequelae No ICU Re
Page 7 and 8: Liberation & Animation Ely EW, et a
Page 9 and 10: Sedation Protocols: The Evidence Tr
Page 11: Patients Receiving Mechanical Venti
Page 15 and 16: Spontaneous Breathing Trial
Page 17 and 18: Daily Dose of Opiates 6000 Usual Ca
Page 19 and 20: Patients Discharged from the ICU (%
Page 21 and 22: Patients Alive (%) 100 80 One-Year
Page 23 and 24: Long-Term Cognitive Outcomes Time o
Page 25 and 26: Randomized Trial of Light vs. Deep
Page 27 and 28: Outcome Primary Endpoint 4 weeks af
Page 29 and 30: Animation early mobilization
Page 31 and 32: Schweickert et al, Lancet 2009;373:
Page 33 and 34: Animation = Less Delirium Variable
Page 36 and 37: The BRAIN ICU Project - Overview -

Liberation from Mechanical Ventilation E. Wesley Ely, MD, MPH

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