Liberation from Mechanical Ventilation E. Wesley Ely, MD, MPH

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Baseline Characteristics Characteristic* Control (n=168) Intervention (n=167) Age, years 64 [51-75] 60 [48-71] Female, % 49 46 APACHE II score 26.5 [21-31] 26 [21-33] ICU admission diagnosis, n (%) Sepsis/ARDS 53 47 MI/CHF 17 13 COPD/Asthma 7 10 Altered mental status 7 11 Other 16 19 Girard TD, et al. Lancet 2008;371:126-34
Patients Discharged <strong>from</strong> the ICU (%) ICU Length of Stay 100 reduced ICU stay by =4 days 80 60 SAT+SBT (n=167) 40 SBT (n=168) 20 p=.01 0 0 7 14 21 28 Days Girard TD, et al. Lancet 2008;371:126-34
Page 1 and 2: Wake Up and Breathe: Liberation and
Page 3 and 4: Pain Lack of sleep Difficulty breat
Page 5 and 6: % Neurocognitive Sequelae No ICU Re
Page 7 and 8: Liberation & Animation Ely EW, et a
Page 9 and 10: Sedation Protocols: The Evidence Tr
Page 11 and 12: Patients Receiving Mechanical Venti
Page 13 and 14: ABC Trial - Objectives • To deter
Page 15 and 16: Spontaneous Breathing Trial
Page 17: Daily Dose of Opiates 6000 Usual Ca
Page 21 and 22: Patients Alive (%) 100 80 One-Year
Page 23 and 24: Long-Term Cognitive Outcomes Time o
Page 25 and 26: Randomized Trial of Light vs. Deep
Page 27 and 28: Outcome Primary Endpoint 4 weeks af
Page 29 and 30: Animation early mobilization
Page 31 and 32: Schweickert et al, Lancet 2009;373:
Page 33 and 34: Animation = Less Delirium Variable
Page 36 and 37: The BRAIN ICU Project - Overview -

Liberation from Mechanical Ventilation E. Wesley Ely, MD, MPH

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