Liberation from Mechanical Ventilation E. Wesley Ely, MD, MPH

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Study Aim To test the effect of two different sedation goals, light and deep sedation, on short and long-term mental health Treggiari M, Crit Care Med. 2009;37:2527-34
Outcome Primary Endpoint 4 weeks after ICU discharge Ramsay 1-2 Ramsay 3-4 n = 52 n = 50 P PTSD score 46 29 56 29 .07 Anxiety score 5.3 5.0 5.0 4.2 .64 Depression score 3.4 3.7 3.1 3.7 .72 Treggiari M, Crit Care Med. 2009;37:2527-34
Page 1 and 2: Wake Up and Breathe: Liberation and
Page 3 and 4: Pain Lack of sleep Difficulty breat
Page 5 and 6: % Neurocognitive Sequelae No ICU Re
Page 7 and 8: Liberation & Animation Ely EW, et a
Page 9 and 10: Sedation Protocols: The Evidence Tr
Page 11 and 12: Patients Receiving Mechanical Venti
Page 13 and 14: ABC Trial - Objectives • To deter
Page 15 and 16: Spontaneous Breathing Trial
Page 17 and 18: Daily Dose of Opiates 6000 Usual Ca
Page 19 and 20: Patients Discharged from the ICU (%
Page 21 and 22: Patients Alive (%) 100 80 One-Year
Page 23 and 24: Long-Term Cognitive Outcomes Time o
Page 25: Randomized Trial of Light vs. Deep
Page 29 and 30: Animation early mobilization
Page 31 and 32: Schweickert et al, Lancet 2009;373:
Page 33 and 34: Animation = Less Delirium Variable
Page 36 and 37: The BRAIN ICU Project - Overview -

Liberation from Mechanical Ventilation E. Wesley Ely, MD, MPH

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