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Chance, bias and confounding - The INCLEN Trust

Chance, bias and confounding - The INCLEN Trust

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Confounding <strong>and</strong> effect<br />

modification<br />

• Confounding distorts the true relationship between<br />

the exposure <strong>and</strong> disease <strong>and</strong> should be controlled<br />

• Effect modification tells us that the association<br />

between exposure <strong>and</strong> disease is modified by a<br />

third factor. It should not be controlled for, the<br />

magnitude of effect modification should be<br />

reported <strong>and</strong> biological explanation for its<br />

presence sought.

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