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The 2 nd Young Investigators<br />
Stem Cell meeting<br />
Sponsored by<br />
Legacy Heritage Fund of New York<br />
Biological Industries<br />
PeproTech<br />
Lavi Ltd<br />
Mintz Auditorium , Bar-Ilan University,<br />
Tuesday, December 22, 2009<br />
השתתפות בכנס וחברות באגודה לתאי גזע<br />
כרוכים בתשלום בסך ₪ 50<br />
אנא אשרו הגעה לדוא"ל: iscs2009young@gmail.com
The 2 nd Young Investigators Stem Cell<br />
meeting<br />
Mintz Auditorium, Bar-Ilan University,<br />
Tuesday, December 22, 2009<br />
0830-0900 Registration, coffee<br />
0900-0910 Opening Remarks<br />
0910-1110 Session 1<br />
Chairmen: Prof. Ron Goldstein, Dr. Michal Amit<br />
0910-0925 Re-activation of dormant renal stem/progenitor genes in somatic human kidney cells<br />
via transcriptional re<strong>program</strong>ming and Wnt pathway modulation<br />
D. Omer<br />
Dept. of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical<br />
Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv<br />
0925-0940 Molecular mechanisms controlling gene expression in developing and mature<br />
pancreatic beta-cells<br />
K. Bahar<br />
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot<br />
0940-0955 Macrophage Subpopulations are Essential for Infarct Repair With and Without Stem<br />
Cell Therapy<br />
T. Ben-Mordechai<br />
Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center<br />
0955-1010 Bronchial and Alveolar Epithelium Differentiated from Embryonic Stem Cells A143<br />
A. Ben-Yehudah<br />
Division of Developmental and Regenerative Medicine, Department of Obstetrics,<br />
Gynecology, and Reproductive Sciences<br />
1010-1025 Endothelial progenitors contribute to the heart endocardium and play key roles in<br />
cardiac development<br />
M. Milgrom-Hoffman<br />
Department of Biological Regulation, Weizmann Institute of Science, Rehovot<br />
1025-1040 Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells A117<br />
L. Zwi<br />
Sohnis Family Research Laboratory for Cardiac Electrophysiology and<br />
Regenerative Medicine, the Rappaport Family Institute for Research in the Medical<br />
Sciences, Technion<br />
1040-1055 A human neuron injury model for molecular studies of axonal regeneration A139<br />
L. Ziegler<br />
Bar-Ilan Univ., Ramat-Gan<br />
1055-1110 Clone and gene specific aberrations of parental imprinting in human induced<br />
pluripotent stem cells<br />
M. Pick<br />
Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew<br />
University, Jerusalem<br />
A127<br />
A114<br />
A137<br />
A123<br />
A118
1110-1140 Coffee break, posters, exhibition<br />
1140-1340 Session 2<br />
Chairmen: Dr. Benjamin Dekel, Prof. Dan Gazit<br />
1140-1155 Expansion of Normal and Leukemic Hematopoietic Stem/Progenitor Cells requires<br />
bFGF Downregulation of ROS Levels and Activation of c-Kit and Its Downstream<br />
JAK2/STAT5 Signaling<br />
T. Itkin<br />
Department of Immunology, Weizmann Institute of Science, Rehovot<br />
1155-1210 Role of RNA editing in differentiation of human embryonic stem cells A135<br />
S. Osenberg<br />
Cancer Research Center, Sheba Medical Center, Tel Hashomer, Sackler School of<br />
Medicine, Tel Aviv University<br />
1210-1225 Oligodendrocytes derived from human embryonic stem cells myelinate DRG<br />
neurons in-vitro: study of gene expression and signaling<br />
I. Michal<br />
Molecular Genetics, Weizmann Institute of Sciences, Rehovot<br />
1225-1240 Enhancement of pig embryonic implants in factor VIII KO mice:<br />
A novel role for the coagulation cascade in organ size control<br />
A. Aronovich<br />
Department of Immunology, Weizmann Institute of Science, Rehovot<br />
1240-1255 Transplanted Neural Precursors Enhance Host Brain- Derived Myelin Regeneration A141<br />
O. Einstein<br />
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics,<br />
Hadassah – Hebrew University Medical Center, Jerusalem<br />
1255-1310 Adipose Originated Human Mesenchymal Stem Cells Modulate HUMAN CD8<br />
Expression<br />
I. Nahor<br />
Bruce Rappaport Faculty of Medicine, Technion Haifa<br />
1310-1325 Murine Mesenchymal Stromal Cells Show Limited Tumorigenic Potential Even<br />
Following Prolonged Culture and Repeated Passaging<br />
O. Shoshani<br />
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot<br />
1325-1340 Non Union Bone Defect Regeneration using In-vivo Electroporation of Host<br />
Progenitor Cells<br />
N. Kimelman-Bleich<br />
Hebrew University–Hadassah Medical Campus, Jerusalem<br />
A138<br />
A122<br />
A103<br />
A125<br />
A110<br />
A124<br />
1340-1440 Lunch, posters, exhibition
1440-1610 Session 3 (8 min presentation 2 min Q&A)<br />
Chairmen: Prof. Daniel Offen, Prof. Dafna Benayahu<br />
1440-1450 Molecular characterization of Mesenchymal Stem Cells and the involvement in<br />
driving tumor growth and metastatic progression<br />
G. Santar Chen<br />
Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-<br />
Aviv University, Tel-Aviv<br />
1450-1500 Neurotrophic factors secreted by differentiated mesenchymal stem cells rescue<br />
motorneurons in culture and in animal models<br />
M. Dadon- Nachum<br />
Laboratory of Neurosciences, Felsenstien Medical Research Center, Sackler Faculty<br />
of Medicine, Tel Aviv University<br />
1500-1510 Molecular characterization and functional properties of cardiomyocytes derived<br />
from human inducible pluripotent stem cells<br />
O. Sedan<br />
The Sohnis Family Stem Cells Center, The Rappaport Family Institute for Research<br />
in the Medical Sciences, Technion<br />
1510-1520 Developmental plasticity of adult stem cells derived from the bone marrow A115<br />
L. Iskovich<br />
Frankel Laboratory, Department of Pediatric Hematology Oncology, Schneider<br />
Children’s Medical Center of Israel, Petach Tikva<br />
1520-1530 TGFβ1/Affinity-bound Alginate Scaffold Enhances Chondrogenic Differentiation of<br />
Human Mesenchymal Stem Cells<br />
T. Re'em<br />
Department of Biotechnology Engineering, Ben-Gurion University of the Negev<br />
1530-1540 Activated mesenchymal cells and Kynurenine as therapy for graft versus host<br />
disease in bone marrow transplanted mice<br />
L. Hinden<br />
Department of Bone marrow transplantation, Hadassah-Hebrew University Medical<br />
Center, Jerusalem, Israel.<br />
1550-1600 Growth Factors Enhance Differentiation of Adult Bone Marrow Derived Stem Cells<br />
in Ischemic Murine Retina<br />
B.C. Revital<br />
The Krieger Eye Research Laboratory, Ophthalmology Department, Rabin Medical<br />
Center, Petah Tikva; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv<br />
1600-1610 A New In Vivo Platform for Studying the Growth of Neoplastic Hematopoietic<br />
Cells and the Preclinical Assessment of Anti-Cancer Therapies<br />
M. Cipok<br />
The Hematology Institute, Tel Aviv Tel Aviv Sourasky Medical Center, Tel-Aviv<br />
1610-1625 Announcement of winners and awarding of prizes<br />
A107<br />
A121<br />
A128<br />
A136<br />
A116<br />
A105<br />
A120
Poster Session<br />
Proteomics and Molecular Profiling of Human Embryonic Stem Cells in Early Differentiation Stage<br />
A. Novak-Petraro<br />
Stem Cell Center, Faculty of Medicine, Technion<br />
Cell sorting, clonal analysis and sphere-formation identify cells with progenitor potential in the adult<br />
human kidney<br />
E. Buzhor<br />
Dept. of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel<br />
Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel<br />
Toll-like receptors regulate mesenchymal stromal cell (MSC) functions<br />
M. Pevsner-Fischer<br />
Department of Molecular Cell Biology and Immunology, Weizmann Institute of Science, Rehovot,<br />
Genetically Modified Mesenchymal Stem Cells Induce Brown Adipose Tissue Formation<br />
D. Sheyn<br />
Hebrew University of Jerusalem, Jerusalem<br />
Embryonic pig pancreatic tissue for the treatment of diabetes: Potential role of immune suppression<br />
with ‘off-the-shelf’ 3rd party Tregs<br />
D. Tchorsh-Yutsis<br />
Department of Immunology, Weizmann Institute of Science, Rehovot<br />
Directed differentiation of human embryonic stem cells towards mesenchymal stem cells<br />
H. Domev<br />
Technion, Israel Institute of Technology, Medicine Faculty, Stem Cells Center<br />
Human Mesenchymal Stem Cells: A potential therapeutic tool in immune-mediated &<br />
neurodegenerative diseases<br />
I. Kassis<br />
Department of Neurology and Multiple Sclerosis Center, Hadassah-Hebrew University Medical<br />
Center, Jerusalem, Israel<br />
Stem Cell-Mediated Regenerated Bone Remodels and Regains Biomechanical Competence Based<br />
on Micro Finite Element Analysis<br />
I. Kallai<br />
Skeletal Biotech Laboratory, The Hebrew University of Jerusalem, Israel<br />
Expression of Stem Cell Markers in the Human Fetal Kidney<br />
S. Metsuyanim<br />
Dept. of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center<br />
Characterization of Gastrulation-Stage Progenitor Cells and Their Inhibitory Cross-Talk in Human<br />
Embryoid Bodies<br />
O. Kopper<br />
Stem Cell Unit, Department of Genetics, The Institute of Life Sciences, The Hebrew University<br />
Resistance or sensitivity of Wilms’ tumor to anti-FZD7 antibody highlights the Wnt pathway as a<br />
possible therapeutic target<br />
N. Pode-Shakked<br />
Poster no<br />
P104<br />
P106<br />
P101<br />
P108<br />
P109<br />
P111<br />
P112<br />
P113<br />
P119<br />
P126<br />
P129
Poster Session<br />
Poster no<br />
Dept. of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Sackler<br />
School of Medicine, Tel Aviv University<br />
In vivo tumor formation and tumor - initiating cells in nephroblastoma/Wilms tumor<br />
N. Pode-Shakked<br />
Dept. of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Sackler<br />
School of Medicine, Tel Aviv University<br />
Targeting the hair follicle bulge stem cells<br />
R. Kedmi<br />
Dept. of Cell Research & Immunology,George S. Wise Faculty of Life Sciences ,Tel Aviv<br />
University<br />
Using high-throughput proteomics approaches to promote efficient differentiation of hESCs to<br />
pancreatic β-cells<br />
R. Sharivkin<br />
Biological Chemistry Weizmann Institute of Science<br />
Induced mesenchymal stem cells secrete neurotrophic factors and attenuate neurotoxicity in animal<br />
models of Parkinson's disease<br />
O. Sadan<br />
Laboratory of Neurosciences, Felsenstien Medical Research Center, Sackler Faculty of Medicine,<br />
Tel Aviv University<br />
Heterogeneity in the response of mesenchymal stromal cells to Toll-like receptor activation<br />
L. Sarit<br />
Department of Molecular Cell Biology and Immunology, Weizmann Institute of Science, Rehovot,<br />
Israel<br />
Epigenetic Memory in Fragile-X Induced Pluripotent Stem Cells<br />
O. Bar-Nur<br />
Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew<br />
University, Jerusalem<br />
Apoptotic and tropic functions of TRAIL in human umbilical cord blood<br />
K. Mizrahi<br />
Frankel Laboratory, Center for Stem Cell Research<br />
P130<br />
P131<br />
P132<br />
P133<br />
P134<br />
P140<br />
P142<br />
Thank you:<br />
Prof. Ron Goldstein for organizing and hosting<br />
Abstract Reviewers and graders:<br />
Dr. Michal Amit, Prof. Nissim Benvenisty , Dr. Benny Dekel, Prof. Dan Gazit,<br />
Prof. Ron Goldstein, Dr. Miguel Weil , Prof. Dov Zipori.<br />
Evaluation committee:<br />
Dr. Michal Amit, Prof. Nissim Benvenisty , Dr. Zulma Gazit, Dr. Eldad Tzahor,<br />
Dr. Miguel Weil.
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