Curriculum Vitae - College of Pharmacy - Nova Southeastern ...
Curriculum Vitae - College of Pharmacy - Nova Southeastern ...
Curriculum Vitae - College of Pharmacy - Nova Southeastern ...
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A. LYMPEROPOULOS-CV<br />
27) Lymperopoulos, A., Rengo, G., Gao, E., Ebert, S.N., Dorn, G.W. 2nd, Koch, W.J. Reduction<br />
<strong>of</strong> sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure<br />
progression and improves cardiac function after myocardial infarction. J. Biol. Chem. 285:<br />
16378-16386 (2010)<br />
28) Rengo, G., Leosco, D., Zincarelli, C., Marchese, M., Corbi, G., Liccardo, D., Filippelli, A.,<br />
Ferrara, N., Lisanti, M.P., Koch, W.J., Lymperopoulos, A. Adrenal GRK2 lowering is an<br />
underlying mechanism for the beneficial sympathetic effects <strong>of</strong> exercise training in heart<br />
failure. Am. J. Physiol. Heart Circ. Physiol. 298: H2032-H2038 (2010)<br />
29) Kassimatis, T.I., Nomikos, A., Giannopoulou, I., Lymperopoulos, A., Moutzouris, D.A.,<br />
Varakis, I., Nakopoulou, L. Transcription factor Sp1 expression is upregulated in human<br />
glomerulonephritis: correlation with pSmad2/3 and p300 expression and renal injury. Ren.<br />
Fail. 32: 243-253 (2010)<br />
30) Lymperopoulos, A., Rengo, G., Zincarelli, C., Kim, J., Soltys, S., Koch W.J. An adrenal β-<br />
arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone<br />
production in vitro and in vivo. Proc. Natl. Acad. Sci. USA 106: 5825-5830 (2009)<br />
31) Rengo, G., Lymperopoulos, A., Koch W.J. Future G-protein coupled receptor targets for<br />
treatment <strong>of</strong> heart failure. Curr. Treat. Options Cardiovasc. Med. 11: 328-338 (2009).<br />
Review.<br />
32) Rengo, G., Lymperopoulos, A., Zincarelli, C., Donniacuo, M., Soltys, S., Rabinowitz, J.E.,<br />
Koch W.J. Myocardial adeno-associated virus serotype 6-betaARKct gene therapy<br />
improves cardiac function and normalizes the neurohormonal axis in chronic heart failure.<br />
Circulation 119: 89-98 (2009)<br />
33) Lymperopoulos, A., Rengo, G., Zincarelli, C., Soltys, S., Koch W.J. Modulation <strong>of</strong> Adrenal<br />
Catecholamine Secretion by In Vivo Gene Transfer and Manipulation <strong>of</strong> G Protein-Coupled<br />
Receptor Kinase-2 Activity. Mol. Ther. 16: 302-307 (2008)<br />
34) Lymperopoulos, A., Rengo, G., Koch, W.J. Adrenal adrenoceptors in heart failure: Finetuning<br />
cardiac stimulation. Tr. Mol. Med. 13: 503-511 (2007). Invited review, featured<br />
cover article.<br />
35) Lymperopoulos, A., Rengo, G., Funakoshi, H., Eckhart, A.D., Koch, W.J. Adrenal GRK2<br />
upregulation mediates sympathetic overdrive in heart failure. Nat. Med. 13: 315-323<br />
(2007). Important Note: This journal (“Nature Medicine”) is the top primary research<br />
journal in Medicine (Research and Experimental), with an “Impact Factor” <strong>of</strong> 27.553 (2008<br />
ISI Journal Citation Reports).<br />
36) Leosco, D., Rengo, G., Iaccarino, G., Filippelli, A., Lymperopoulos, A., Zincarelli, C.,<br />
Fortunato, F., Golino, L., Marchese, M., Esposito, G., Rapacciuolo, A., Rinaldi, B., Ferrara,<br />
N., Koch, W.J., Rengo, F. Exercise training and beta-blocker treatment ameliorate agedependent<br />
impairment <strong>of</strong> beta-adrenergic receptor signaling and enhance cardiac<br />
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