March/April - West Virginia State Medical Association
March/April - West Virginia State Medical Association
March/April - West Virginia State Medical Association
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Scientific Article |<br />
Figure 2.<br />
A 66 year old female on alendronate for 7 years noted bilateral thigh pain for several<br />
weeks. When turning from a standing position, she experienced severe thigh pain and<br />
was caught by a friend. A transverse fracture was noted at a thickened cortical site (a).<br />
Nuclear imaging revealed a contralateral stress reaction (b).<br />
Figure 3.<br />
A 68 year-old white female who received<br />
estrogen and bisphosphonates for 5.5<br />
years experienced right thigh pain for 2<br />
weeks causing her to fall which resulted<br />
in a subtrochanteric fracture.<br />
orthopedists William G. Sale, MD<br />
and Tony C. Majestro, MD for their<br />
review of cases and radiographic<br />
images; and the late Paul D.<br />
Saville, MD for his comments.<br />
References<br />
1. Chavassieux P, Seeman E, Delmas PD.<br />
Insights into the material and structural<br />
basis of bone fragility from diseases<br />
associated with fracture: How determinants<br />
of the biomechanical properties of bone are<br />
compromised by disease. Endocrine<br />
Reviews. 2007;28:151-164.<br />
2. NIH Consensus Development Panel on<br />
Osteoporosis, Diagnosis, and Therapy.<br />
Osteoporosis diagnosis, and therapy. JAMA<br />
2001;285:785-795.<br />
3. Greenspan S, Parker RA, Ferguson L,<br />
Rosen HN, Maitland-Ramsey L, Karpf DB.<br />
Early changes in biochemical markers of<br />
bone turnover predict the long-term<br />
response to alendrodronate therapy in<br />
representative elderly women. J Bone Miner<br />
Res 1998;13:1431- 1438.<br />
4. Cummings SR, Karpf DB, Harris F, et al.<br />
Improved spine bone mineral density and<br />
reduction in risk of vertebral fractures during<br />
treatment with antiresorptive drugs. Am J<br />
Med. 2002;112;281-289.<br />
5. Wells GA, Craney A, Peterson J, et al.<br />
Alendronate for the primary and secondary<br />
prevention of osteoporotic fractures in<br />
postmenopausal women. Cochrane<br />
Database of Systematic Reviews. 2008,<br />
Issue 1. Art No.:CD001155.<br />
DOI:10.1002/14651858. CD001155.pub2.<br />
6. Bone HG, Hosking D, Devogelaer J-P, et al.<br />
Ten years’ experience with alendronate for<br />
osteoporosis. New Engl J Med<br />
2004;350:1189-1199.<br />
7. Tonino R, Meunier PJ, Emkey R, et al.<br />
Skeletal benefits of alendronate: 7-Year<br />
treatment of postmenopausal osteoporotic<br />
women. J Clin Endocrinol Metab<br />
2000;85:3109-3115.<br />
8. Black DM, Schwartz AV,Ensrud KE, et al.<br />
Effects of continuing or stopping<br />
alendronate after 5 years of treatment.<br />
JAMA 2006;296:2927-2938.<br />
9. Ott SM. Fractures after long-term<br />
alendronate therapy. J Clin Endocrinol<br />
Metab. 2001;86: 1835.<br />
10. Hirano T, Turner CH, Forwood MR,<br />
Johnston CC, Burr DB. Does suppression<br />
of bone turnover impair mechanical<br />
properties by allowing microdamage<br />
accumulation Bone. 2000;21:13-20.<br />
11. Odvina CV, Zerwekh JE, Sudhaker Rao D,<br />
Maalouf N, Gottshalk FA, Pak CYC.<br />
Severely suppressed bone turnover: A<br />
potential complication of alendronate<br />
therapy. J Clin Endo- crinol Metab.<br />
2005;90:1294-1301.<br />
12. Goh SK, Yang KY, Koh JSB, et al.<br />
Subtrochanteric insufficiency fractures in<br />
patients on alendronate therapy: A caution.<br />
J Bone Joint Surg Br. 2007;89:349-353.<br />
13. Cheung RKH, Leung KK, Lee KC, Chow<br />
TC. Sequential non-traumatic femoral neck<br />
fractures in a patient on long-term<br />
alendronate. Hong Kong Med J.<br />
2007;13:485-489.<br />
12 <strong>West</strong> <strong>Virginia</strong> <strong>Medical</strong> Journal