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March/April - West Virginia State Medical Association

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Scientific Article |<br />

Figure 2.<br />

A 66 year old female on alendronate for 7 years noted bilateral thigh pain for several<br />

weeks. When turning from a standing position, she experienced severe thigh pain and<br />

was caught by a friend. A transverse fracture was noted at a thickened cortical site (a).<br />

Nuclear imaging revealed a contralateral stress reaction (b).<br />

Figure 3.<br />

A 68 year-old white female who received<br />

estrogen and bisphosphonates for 5.5<br />

years experienced right thigh pain for 2<br />

weeks causing her to fall which resulted<br />

in a subtrochanteric fracture.<br />

orthopedists William G. Sale, MD<br />

and Tony C. Majestro, MD for their<br />

review of cases and radiographic<br />

images; and the late Paul D.<br />

Saville, MD for his comments.<br />

References<br />

1. Chavassieux P, Seeman E, Delmas PD.<br />

Insights into the material and structural<br />

basis of bone fragility from diseases<br />

associated with fracture: How determinants<br />

of the biomechanical properties of bone are<br />

compromised by disease. Endocrine<br />

Reviews. 2007;28:151-164.<br />

2. NIH Consensus Development Panel on<br />

Osteoporosis, Diagnosis, and Therapy.<br />

Osteoporosis diagnosis, and therapy. JAMA<br />

2001;285:785-795.<br />

3. Greenspan S, Parker RA, Ferguson L,<br />

Rosen HN, Maitland-Ramsey L, Karpf DB.<br />

Early changes in biochemical markers of<br />

bone turnover predict the long-term<br />

response to alendrodronate therapy in<br />

representative elderly women. J Bone Miner<br />

Res 1998;13:1431- 1438.<br />

4. Cummings SR, Karpf DB, Harris F, et al.<br />

Improved spine bone mineral density and<br />

reduction in risk of vertebral fractures during<br />

treatment with antiresorptive drugs. Am J<br />

Med. 2002;112;281-289.<br />

5. Wells GA, Craney A, Peterson J, et al.<br />

Alendronate for the primary and secondary<br />

prevention of osteoporotic fractures in<br />

postmenopausal women. Cochrane<br />

Database of Systematic Reviews. 2008,<br />

Issue 1. Art No.:CD001155.<br />

DOI:10.1002/14651858. CD001155.pub2.<br />

6. Bone HG, Hosking D, Devogelaer J-P, et al.<br />

Ten years’ experience with alendronate for<br />

osteoporosis. New Engl J Med<br />

2004;350:1189-1199.<br />

7. Tonino R, Meunier PJ, Emkey R, et al.<br />

Skeletal benefits of alendronate: 7-Year<br />

treatment of postmenopausal osteoporotic<br />

women. J Clin Endocrinol Metab<br />

2000;85:3109-3115.<br />

8. Black DM, Schwartz AV,Ensrud KE, et al.<br />

Effects of continuing or stopping<br />

alendronate after 5 years of treatment.<br />

JAMA 2006;296:2927-2938.<br />

9. Ott SM. Fractures after long-term<br />

alendronate therapy. J Clin Endocrinol<br />

Metab. 2001;86: 1835.<br />

10. Hirano T, Turner CH, Forwood MR,<br />

Johnston CC, Burr DB. Does suppression<br />

of bone turnover impair mechanical<br />

properties by allowing microdamage<br />

accumulation Bone. 2000;21:13-20.<br />

11. Odvina CV, Zerwekh JE, Sudhaker Rao D,<br />

Maalouf N, Gottshalk FA, Pak CYC.<br />

Severely suppressed bone turnover: A<br />

potential complication of alendronate<br />

therapy. J Clin Endo- crinol Metab.<br />

2005;90:1294-1301.<br />

12. Goh SK, Yang KY, Koh JSB, et al.<br />

Subtrochanteric insufficiency fractures in<br />

patients on alendronate therapy: A caution.<br />

J Bone Joint Surg Br. 2007;89:349-353.<br />

13. Cheung RKH, Leung KK, Lee KC, Chow<br />

TC. Sequential non-traumatic femoral neck<br />

fractures in a patient on long-term<br />

alendronate. Hong Kong Med J.<br />

2007;13:485-489.<br />

12 <strong>West</strong> <strong>Virginia</strong> <strong>Medical</strong> Journal

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