Innovative Imaging Probes - Encite

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NMR and its Holy Grail <strong>Imaging</strong> 13 C-labelled urea in a rat Metabolic imaging of a rat tumor with hyperpolarized 13 C-pyruvate R3230AC, mammary adenocarcinoma 1 H-reference pyruvate alanine lactate 10
Equilibrium p-H 2 percentage Para-hydrogen Induced Polarization (PHIP) What Para-Hydrogen is bb c(ab+ba) Triplet (ortho) aa c(ab-ba) Singlet (para) 100 80 60 Normal Hydrogen = 75% ortho + 25% para 40 20 0 100 200 300 400 500 Temperature (K) Para-Hydrogen Induced Polarization (PHIP) D D H H D D d 5 D + p-H 2 D d 5 Resulting 1 H NMR spectrum: Ortho-H 2 I = 0 ab bb Para-H 2 I = 0 Para-H 2 aa AX spin system ba Signal enhancement up to 10 5 11
Page 1 and 2: The European Network for Cell Imagi
Page 3 and 4: ST % The MR-CEST experiment Aqueous
Page 5 and 6: ST% SR LIPOCEST agents Hydration Vo
Page 7 and 8: Innovative Imaging Probes CEST age
Page 9: Dynamic Nuclear Polarization (DNP)
Page 13 and 14: The Nycomed approach: Para-H 2 cont

Innovative Imaging Probes - Encite

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