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Innovative Imaging Probes - Encite

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Routes to hyperpolarization<br />

Laser excitation ( 3 He or 129 Xe)<br />

“Brute Force”<br />

Dynamic Nuclear Polarization (DNP)<br />

Para-hydrogen Induced Polarization (PHIP)<br />

Laser-Polarized 3 He and 129 Xe<br />

h n<br />

Rb<br />

Rb<br />

Rb<br />

Rb<br />

Rb<br />

Rb<br />

Hyperpolarization<br />

of Rb atoms<br />

The radiation is circularly polarized;<br />

the Rb D1 line is used (corresponding<br />

to the 5s 1 -/ 25p transition)<br />

1 / 2<br />

Collisions between<br />

Rb and Xe<br />

Rb<br />

Xe<br />

(Van der Waals molecule)<br />

Polarization transfer to Xe atoms<br />

via “spin exchange”<br />

Xe<br />

Xe<br />

Xe<br />

8

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