Innovative Imaging Probes - Encite
Innovative Imaging Probes - Encite
Innovative Imaging Probes - Encite
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How to increase the number of mobile protons <br />
Use of nanoparticles<br />
Liposomes<br />
- well-known biocompatible systems<br />
- a liposome with 200 nm of diameter contains<br />
k ex<br />
about 2.410 8 mobile water protons!<br />
- k ex values cover a wide range (10-10 6 s -1 )<br />
depending on the chemical composition of<br />
the liposome membrane<br />
In order to act as CEST agent, the resonance frequency of<br />
the water protons inside the liposome must be shifted<br />
LIPOCEST agents: a new entry for highly-sensitive CEST probes<br />
The encapsulation of a paramagnetic shift reagent (SR) in liposomes<br />
affects the resonance frequency of the water protons inside the vesicle<br />
bulk<br />
water<br />
k ex<br />
SR<br />
Ln<br />
<br />
d wat-lip<br />
water<br />
inside lipos.<br />
40 30 20 10 0 -10 -20 -30 -40<br />
KHz<br />
d wat-lip depends on the type and concentration of SR<br />
k ex depends on the membrane composition and liposome size<br />
4
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