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Human Arterial Tree Simulation on TeraGrid - Center for Fluid ...

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<str<strong>on</strong>g>Human</str<strong>on</strong>g> <str<strong>on</strong>g>Arterial</str<strong>on</strong>g> <str<strong>on</strong>g>Tree</str<strong>on</strong>g><br />

<str<strong>on</strong>g>Simulati<strong>on</strong></str<strong>on</strong>g> <strong>on</strong> <strong>TeraGrid</strong><br />

The CRUNCH group is a research group in the Divisi<strong>on</strong> of Applied Mathematics<br />

at Brown University. The thrust of its research is the development of numerical<br />

algorithms, visualizati<strong>on</strong> methods and parallel software <strong>for</strong> c<strong>on</strong>tinuum and<br />

atomistic simulati<strong>on</strong>s in fluid mechanics and related applicati<strong>on</strong>s.<br />

Sketch of the human<br />

vascular system<br />

<str<strong>on</strong>g>Arterial</str<strong>on</strong>g> <str<strong>on</strong>g>Tree</str<strong>on</strong>g> Project<br />

Cranial arteries rec<strong>on</strong>structed<br />

from MRI images with gOREK<br />

! Goal: to model blood flow interacti<strong>on</strong>s in different<br />

regi<strong>on</strong>s of the cardiovascular system.<br />

! High-per<strong>for</strong>mance computing is essential <strong>for</strong> modeling<br />

3D unsteady fluid mechanics in arterial systems.<br />

! Accurately capturing flow dynamics requires high<br />

spatial resoluti<strong>on</strong> and meshes with milli<strong>on</strong>s of elements.<br />

! CFD code NEKTAR-G2, developed at Brown, is based<br />

<strong>on</strong> spectral/hp element methods; NEKTAR-G2 can<br />

efficiently handle cross-site simulati<strong>on</strong>s <strong>on</strong> the <strong>TeraGrid</strong>.<br />

! Recent simulati<strong>on</strong>s of 3D flow in the cranial vascular<br />

system involved 65 arteries and the soluti<strong>on</strong> of flow<br />

equati<strong>on</strong>s with over a billi<strong>on</strong> degrees of freedom.<br />

Collaborators:<br />

Brown University<br />

Leopold Grinberg<br />

Susanna Makela<br />

George Karniadakis<br />

Arg<strong>on</strong>ne Nati<strong>on</strong>al Lab<br />

Joseph Insley<br />

Mike Papka<br />

NIU/Arg<strong>on</strong>ne<br />

Nicholas Kar<strong>on</strong>is<br />

Brian To<strong>on</strong>en<br />

Imperial College, UK<br />

Spencer Sherwin<br />

Children's Hospital,<br />

Harvard Medical School<br />

Tomer Anor<br />

Joseph Madsen<br />

Supported by an NSF CI-TEAM grant.<br />

Special thanks to Leland James<strong>on</strong>, Frederica<br />

Darema, and Almadena Chtchelkanova.


Parallel Paradigm <strong>on</strong> <strong>TeraGrid</strong><br />

To handle the computati<strong>on</strong>al demands of these simulati<strong>on</strong>s we turn to the<br />

supercomputing resources offered by the <strong>TeraGrid</strong>, a network integrating powerful<br />

open computing resources in the USA. We are working closely with computer<br />

scientists at Northern Illinois University and Arg<strong>on</strong>ne Nati<strong>on</strong>al Lab to develop<br />

middleware that can facilitate in the transiti<strong>on</strong>ing of simulati<strong>on</strong> executi<strong>on</strong>s from a<br />

single supercomputer to a cluster of supercomputers such as the <strong>TeraGrid</strong>. In<br />

particular, we have focused <strong>on</strong> the use and further development of MPIg, which,<br />

through services provided by the Globus Toolkit, relieves the computati<strong>on</strong>al scientist<br />

from low-level details of secure process management, communicati<strong>on</strong>, and network<br />

topology.<br />

We aim to establish a biomechanics gateway <strong>on</strong> the <strong>TeraGrid</strong> and make the arterial<br />

tree a plat<strong>for</strong>m and a simulati<strong>on</strong> framework <strong>for</strong> further developments and systematic<br />

studies in hemodynamics, disease modeling, and drug delivery.<br />

Computati<strong>on</strong><br />

Visualizati<strong>on</strong><br />

Viewer client: SC07, Reno, NV<br />

Flow data<br />

Servers<br />

Globus handles<br />

secure process<br />

management,<br />

MPIg handles<br />

communicati<strong>on</strong>s<br />

For more in<strong>for</strong>mati<strong>on</strong>, visit http://www.cfm.brown.edu/crunch/ATREE/index.html

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