Soft Lithography
Soft Lithography
Soft Lithography
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Microcontact Printing of Proteins<br />
I<br />
Ink Stamp<br />
Protein<br />
solution<br />
II Blow dry<br />
III Contact<br />
IVSeparate<br />
Structured<br />
PDMS<br />
Stamp<br />
Inked<br />
stamp<br />
Hard<br />
substrate<br />
Patterned<br />
surface<br />
Transfer of proteins from<br />
low to high surface energy<br />
Proteins act as a “solid” ink<br />
– no spreading<br />
Greater than 99% protein<br />
transfer in less than 1<br />
second<br />
Bernard, A., et al., Langmuir 1998, 14, 2225-2229.<br />
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