Company presentation - Mondobiotech

Examples of platforms’ rationales
Interferon - γ (DK 1001)
Known biological activity:
• Antifibrotic
• Antiproliferative
• Antibiotic
Safety:
• Approved for pediatric
and adult use via subcutaneous
injection in Chronic
Granulomatous disease
(CGD) and severe malignant
osteopetrosis.
Rare indications and route
of administration:
• IPF via inhalation.
• Two other indications
via injection and inhalation
to be disclosed after
IP protection.
Aviptadil (DK 1000)
Known biological activity:
• Antinflammatory
• Immunoregulatory
• Antiproliferative
• Antibiotic
• Antiapoptotic
Safety:
• Approved in combination
with phentolamine
in erectile dysfunction.
• Used in various clinical
trials in lung diseases over
more than 2 decades
and hundreds of patients.
Homology with other species:
• Identical in the following species:
human, cow, rat, pig, dog, goat,
sheep, mouse, monkey.
Rare indications and route
of administration:
• PAH via inhalation.
• Sarcoidosis via inhalation.
• ARDS via injection.
• IPF via inhalation.
DasKloster 0210 (DK 0210)
Known biological activity:
• Immunoregulatory
• Anti-pyretic
• Antiproliferative
• Antiallergic
• Antifibrotic
• Antinflammatory
Safety:
• Approved in combination
with met-enkephaline
for multiple sclerosis.
Homology with other species:
• Identical in Human, mice, rat, pig.
Rare indications and route
of administration:
• Chronic Beryllium Disease
via injection.
• Glomerulonephrytis
via injection.
• Chronic Fatigue Syndrome
via injection.
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