Transplant Immunosuppression 2007 - University of Minnesota ...

F 

I 

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TRANSPLANT 

IMMUNOSUPPRESSION 

2007: 

The Ongoing Search 

for Improvement 

A 

L 

A 

NN 

O 

UNCE 

M 

ENT 

October 17-20, 2007 

Radisson University Hotel 

University of Minnesota Campus 

Minneapolis, Minnesota 

EARLY 

REGISTRATION 

DISCOUNT 

ENDS 

SEPTEMBER 14, 2007 

REGISTER NOW! 

Presented by 

Division of Transplantation 

Department of Surgery 

Continuing Medical Education 

University of Minnesota

TRANSPLANT 

IMMUNOSUPPRESSION 2007: 

The Ongoing Search for Improvement 

The congress will focus on immunosuppressive protocols used at different times posttransplant, including efforts to 

improve posttransplant patient and graft survival and to decrease posttransplant morbidity. A major component will 

be the opportunity to interact with faculty who use different immunosuppressive protocols. Arguments for and 

against each protocol will be raised and discussed. Sessions will be devoted to the need (or lack thereof) for steroid 

and/or calcineurin inhibitors and to differing immunosuppressive protocols for the sensitized recipient and recipients 

of ECD and DCD kidneys. 

In addition, plenary lectures will address the supply of organs, antibody-mediated rejection, risk factors for poor longterm 

outcome, immunosuppression for high-risk groups, and protocols utilizing new immunosuppressive agents. 

Again this year we are offering a pre-conference session and afternoon sessions for transplant coordinators. Please 

see the details inside this announcement. 

We look forward to welcoming you in Minneapolis! 

CHAIRMAN 

Arthur J. Matas, MD 

Professor of Surgery 

University of Minnesota Medical School 

LOCAL ORGANIZING 

COMMITTEE 

Blanche Chavers, MD 

Ty B. Dunn, MD 

Rainer Gruessner, MD 

Cynthia Herrington, MD 

Marshall Hertz, MD 

Abhi Humar, MD 

Hassan Ibrahim, MD 

Raja Kandaswamy, MD 

Clifford Kashtan, MD 

Bertram Kasiske, MD 

Aleksandra Kukla, MD 

John Lake, MD 

Connie Manske, MD 

Michael Mauer, MD 

John Najarian, MD 

Tom Nevins, MD 

William Payne, MD 

Mark Rosenberg, MD 

Sara Shumway, MD 

Richard Spong, MD 

David Sutherland, MD, PhD 

The University of Minnesota is committed to the policy that all persons 

shall have equal access to its programs, facilities, and employment 

without regard to race, creed, religion, color, sex, age, marital status, 

disability, public assistance status, veteran status, or sexual orientation. 

Disability/Dietary accommodations will be provided upon request. 

Call Continuing Medical Education at 612-626-7600 or 

1-800-776-8636. 

PLANNING COMMITTEE 

Chair: Catherine Garvey, RN 

Louise Berry, RN 

Marie Cook, RN 

Mary Beth Drangstveit, RN 

Elana Glumac, RN 

Mary Huepfel, RN 

Marci Knaak, RN 

Louis Larmeu, RN 

Marilyn Leister, RN 

Erin Norris, RN 

Mary Rolf, RN 

Marci Siers, RN 

Dawn Thell, RN 

TARGET AUDIENCE 

The conference has been planned to be of 

interest to transplant surgeons, physicians, 

coordinators, researchers, and other health 

professionals involved in the care of these 

patients. 

EDUCATIONAL OBJECTIVES 

Following this activity, participants should 

be able to: 

• Describe the risks (donor and patient) 

associated with transplantation 

• Describe the indications and 

contraindications of the highly sensitized 

and desensitized patient 

• Discuss methods to improve long-term 

recipient survival 

• Describe the new therapies and treatment 

options for transplantation 

• Discuss new immunosuppressive drugs, and 

new protocols to improve long-term graft 

survival (and function), and to minimize 

morbidity (including calcineurin-sparing and 

steroid-sparing protocols) 

COORDINATORS' SESSION

ACCREDITATION 

American Medical Association / PRA 

The University of Minnesota is accredited by the 

Accreditation Council for Continuing Medical 

Education (ACCME) to provide continuing 

medical education for physicians. 

The University of Minnesota designates this educational 

activity for a maximum of 3.0 AMA PRA 

Category 1 Credits for the pre-conference and 

25.5 AMA PRA Category 1 Credits for the main 

conference. Physicians should only claim credit commensurate 

with the extent of their participation in the 

activity. 

Minnesota Board of Nursing 

This activity has been designed to meet the 

Minnesota Board of Nursing continuing education 

requirements. This activity offers 3.6 contact hours of 

continuing education for the pre-conference and 31.5 

contact hours for the main conference, however, the 

nurse is responsible for determining whether this activity 

meets the requirements for acceptable continuing 

education. 

AACN/ABTC 

An application has been submitted to the 

International Transplant Nurses Society. Final 

determination of credits is pending. 

Accreditation Council for Pharmacy Education 

The University of Minnesota College of 

Pharmacy is accredited by the 

Accreditation Council for Pharmacy 

Education as a provider of continuing 

pharmacy education. This program has been planned 

in accordance with the ACPEs Criteria for Quality. 

The Universal Program Numbers are 031-999-07- 

202-L04 through 031-999-07-206-L04. 

This program provides up to 28.25 hours of pharmacy 

continuing education credit. Release date: 

October 2007. 

Following attendance at the program and completion 

of the Verification of Attendance and Program 

Evaluation forms, statements of credit will be mailed to 

participants within 4 weeks. 

MEETING VENUE/LODGING 

Radisson University Hotel - Minneapolis 

University of Minnesota East Bank Campus 

615 Washington Avenue SE 

Minneapolis, Minnesota 55414 

Telephone (612) 379-8888 

or 800-822-6757 

Web Site: wwww.radisson.com/univ_minneapolis 

Rate: $112.00 plus taxes 

Cut-off Date: October 2, 2007 

A block of sleeping rooms is available at the discounted 

rate listed above. Please make your 

reservations directly with the hotel by the cut-off 

date and refer to the course by name to receive 

the discounted rate. Reservations will be accepted 

on space and rate availability. 

DISCLOSURE POLICY 

It is the policy of the University of Minnesota Office 

of Continuing Medical Education to ensure balance, 

independence, objectivity and scientific rigor in all of 

its sponsored educational activities. All participating 

faculty, course directors, and planning committee 

members are required to disclose to the program 

audience any financial relationships related to the subject 

matter of this program. Disclosure information is 

reviewed in advance in order to manage and resolve 

any possible conflicts of interest. Specific disclosure 

information for each course faculty will be shared with 

the audience prior to the faculty’s presentation. 

REGISTRATION FEES AND EARLY 

REGISTRATION DISCOUNT 

Register by SEPTEMBER 14, 2007 to take advantage 

of our Early Registration Discount! See the registration 

form in this brochure for more information. 

A letter of confirmation, driving directions, and parking 

information will be mailed to you once we receive 

your completed registration form. 

REGISTRATION FEES Before After 

Sept. 14 Sept. 14 

Physician $400 $450 

Scientist $300 $350 

Pharmacist $300 $350 

Medical Resident/Fellow $200 $250 

Transplant Coordinator $200 $250 

Other Health Professional $200 $250 

Medical Industry Professional $400 $450 

REGISTRATION FEES INCLUDE: 

• Participation in scientific sessions 

• Conference materials 

• Continental breakfast, lunch and refreshment breaks 

• Welcome reception 

The fee does not include parking. 

CANCELLATION POLICY 

In the event you need to cancel your registration, 

the registration fee, less a $50 administrative fee, 

will be refunded if you notify us by 4:30 p.m. 

Central Time on OCTOBER 1, 2007. No 

refunds will be made after this date. 

TO REGISTER 

You may choose ONE of the following 

methods to register for this conference. 

ONLINE: Go to www.cmecourses.umn.edu 

CALL: (612) 626-7600 or 

(800) 776-8636 

FAX: (612) 626-7766 

MAIL: 

Transplant Immunosuppression 

Conference, Office of Continuing 

Medical Education, 

University of Minnesota, 

190 McNamara Alumni Center, 

200 Oak Street SE, 

Minneapolis, MN 55455 

If you have any questions, please contact our office 

at the number above, or e-mail us at cme@umn.edu.

PRE-CONFERENCE SESSION 

Transplant Program Regulations: 

What Do All The Rules Mean 

Radisson University Hotel • Minneapolis, Minnesota 

PRELIMINARY AGENDA 

Pre-registration and payment is required. See Registration Form for more details. 

WEDNESDAY, OCTOBER 17 

7:00 Registration and Continental Breakfast 

8:00 Welcome and Overview 

Catherine Garvey (Minneapolis, Minnesota) 

8:10 CMS and JCAHO Regulations “Making the Grade” 

Frances Hoffman (Minneapolis, Minnesota) 

9:00 The Rule of UNOS Regulations in Your Transplant Center: 

What’s In Style and What’s Out of Style 

Barry Friedman (Minneapolis, Minnesota) 

9:45 Panel Discussion 

10:00 Break 

TRANSPLANT: READY OR NOT HERE THEY COME! 

10:15 Keeping Patients Ready for Transplant – Why 

Ty B. Dunn (Minneapolis, Minnesota) 

10:30 How I Do It: Keeping Patients Ready for Kidney Transplant 

Kay Kosberg (Rochester, Minnesota) 

Patty Evans (Minneapolis, Minnesota) 

Elana Glumac (Minneapolis, Minnesota) 


Moderator: Mary Beth Drangstveit (Minneapolis, Minnesota) 

11:30 Adjourn

TRANSPLANT IMMUNOSUPPRESSION 2007 

The Ongoing Search for Improvement 

PRELIMINARY AGENDA 

WEDNESDAY, OCTOBER 17 

10:30 Registration 

11:00 Light Buffet Lunch 

12:15 Welcome and Introduction 

Selwyn Vickers (Minneapolis, Minnesota) 

John Najarian (Minneapolis, Minnesota) 

John Najarian, Moderator 

12:30 The Kidney Transplant Wait List – A Growing Crisis 

Robert S. Gaston (Birmingham, Alabama) 

12:55 Risk of Donor Nephrectomy 

Raja Kandaswamy (Minneapolis, Minnesota) 

1:20 Risk of Donor Hepatectomy 

Elizabeth Pomfret (Burlington, Massachusetts) 

1:45 Pregnancy after Donation 

Hassan Ibrahim (Minneapolis, Minnesota) 

2:10 Long-Term Donor Care – The Provider’s Perspective 

Richard Migliori (Minneapolis, Minnesota) 

2:35 Break and Exhibits 

Arthur Matas, Moderator 

3:00 How I Do It (Session I) Living Donors: The Hard Questions 

Carl Cardella (Toronto, Ontario) 

Darla Granger (Detroit, Michigan) 

Daniel Frey (Lafayette, Louisiana) 

Fernando Cosio (Rochester, Minnesota) 

Raja Kandaswamy, Moderator 

3:45 Pros and Cons of Induction Therapy 

Herwig-Ulf Meier-Kriesche (Gainesville, Florida) 

4:10 Symphony Trial 

Philip Halloran (Edmonton, Alberta) 

4:30 How I Do It (Session II) Initial Immunosuppression for LDs 

Fernando Cosio (Rochester, Minnesota) 

Vivian Tellis (Bronx, New York) 

Enrico Benedetti (Chicago, Illinois) 

Lucille Wrenshall (Omaha, Nebraska)

CONCURRENT SESSIONS: 

5:15 Transplant Coordinators’ Session 

Moderator: Marie Cook (Minneapolis, Minnesota) 

Complimentary, Alternative and Integrative Therapies: 

Implications for Transplant Nursing 

Mary Jo Kreitzer (University of Minnesota) 

5:15 Oral Abstract Session 

Pharmacokinetics of Mycophenolic Acid in Liver Transplant Patients After 

Intravenous and Oral Administration of Mycophenolate Mofetil (MMF) 

Ashok Jain MD 1 , 2 , Raman Venkataramanan PhD 2 Tai Kwong PhD 3 ,Ravi Mohanka 

MD 1 , Mark Orloff MD 1 , Peter Abt MD 1 , Randeep Kashyap MD 1 , Georgios 

Tsoulfas, MD 1 , Rajeev Saharma MD 1 , Cindy Mack RN 1 , Pam Batzold RN 1 , 

Adel Bozorgzadeh MD 1 

1 

Department of Surgery, Division of Transplantation: University of Rochester 

Medical Center, Rochester, NY 2 School of Pharmacy University of Pittsburgh 

3 

Department of Biochemistry University of Rochester Medical Center, 

Rochester, NY 

Immunological Advantage of Intravenous Mycophenolate Mofetil with 

Tacrolimus and Steroids in Primary Deceased Donor Liver Transplantation and 

Live Donor Liver Transplantation Without Antibody Induction 

Ashok Jain MD 1 , Rajeev Sharma MD 1 , Charlotte Ryan MD 2 , Georgious Tsoulfas 

MD 1 , Mark Orloff MD 1 , Peter Abt MD 1 , Randeep Kashyap MD 1 , Pam Batzold 

RN 1 , Lisa Sauberman Pharm.D 3 , Saman Safadjou MD 1 , Maureen Graham RN 1 , 

Adel Bozorgzadeh MD 1 

1 

Department of Surgery, Division of Transplantation, University of Rochester 

Medical Center, Rochester, NY 2 Department of Pathology, University of Rochester 

Medical Center, Rochester, NY 3 Department of Pharmacy, University of Rochester 

Medical Center, Rochester, NY 

Rejection Following Thymoglobulin or Alemtuzumab Induction in Deceased 

Donor Renal Transplant 

Mark A Schnitzler MD 1 , Paula Buchanan, MPH, Ambyr Godboldo-Brooks, 

MSW 

1 

Internal Medicine, Saint Louis University, St. Louis, MO 

Long-Term Outcome of Liver Transplant Patients Treated with Induction 

Therapy (IT) with Anti-CD25 Monoclonal Antibodies (MA) 

Sabina C. Magalini MD 1 , Alfonso W. Avolio MD, Francesco Frongillo MD, 

Raffaella Barbarino, MD, Erida Nure MD, Gilda Pepe MD, Salvatore Agnes MD 

1 

Catholic University Department of Surgery, Rome, Italy 

6:15 Welcome Reception at 

Frederick R. Weisman Art Museum

THURSDAY, OCTOBER 18 

7:00 Continental Breakfast and Exhibits 

Ty Dunn, Moderator 

8:00 Understanding the Highly Sensitized Patient 

Ronald Kerman (Houston, Texas) 

8:30 Indications and Contraindications: 

ABO Incompatible, Paired Exchange, Desensitization 

Robert Montgomery (Baltimore, Maryland) 

8:50 Commentary 

James Gloor (Rochester, Minnesota) 

9:00 Desensitization and ABO Incompatible in African Americans 

Bruce Kaplan (Chicago, Illinois) 

9:20 The Protocol 


9:40 Commentary 



Kerman, Montgomery, Gloor, Kaplan 


Hassan Ibrahim, Moderator 

10:45 Pathology of Humoral Rejection 

Robert Colvin (Boston, Massachusetts) 

11:10 The Importance of Late Donor Specific Antibody 

Philip Halloran (Edmonton, Alberta) 

11:30 Treatment of Early C4d positive AR 


11:50 Long-term Immunosuppression in the Highly Sensitized Patient 



Colvin, Halloran, Montgomery, Gloor 

12:30 Lunch 

David Sutherland, Moderator 

1:30 What’s New in the Pipeline 

Allan Kirk (Bethesda, Maryland) 

2:00 When to Say “No” to Transplantation 

Douglas Hanto (Boston, Massachusetts) 

2:20 Wait List Management 

Suphamai “Mike” Bunnapradist (Los Angeles, California) 

2:40 Pretransplant Malignancy: When is it Acceptable to Transplant 

Joseph Buell (Louisville, Kentucky) 

3:00 How I Do It (Session III) Initial Immunosuppression for 

Standard Criteria Deceased Donor Transplant 

R. Brian Stevens (Omaha, Nebraska) 

Flavio Vincenti (San Francisco, California) 

Robert Gaston (Birmingham, Alabama) 

3:40 Break and Exhibits

William Payne, Moderator 

4:00 Pregnancy after Transplantation 

Vincent Armenti (Philadelphia, Pennsylvania) 

4:20 Expanded Criteria Donor Outcome 

Herwig-Ulf Meier-Kriesche (Gainesville, Florida) 

4:40 How I Do It (Session IV) Initial Immunosuppression for Expanded Criteria Donor Transplants 

Ronald Ferguson (Columbus, Ohio) 

Douglas Hanto (Boston, Massachusetts) 

Vivian Tellis (Bronx, New York) 

Enrico Benedetti (Chicago, Illinois) 



Moderator: Mary Beth Drangstveit (Minneapolis, Minnesota) 

Show Me the Money: Medicare Part D and Insurance Issues 

Kari Amundson (Minneapolis, Minnesota) 

5:15 Oral Abstract Session 

Sirolimus Versus Mycophenolate Mofetil in Simultaneous Pancreas-Kidney 

Transplantation: 1 Year Results of A Multicenter Trial 

6:15 Adjourn 

Jacques Malaise, MD 1 , J. Pratschke, F. Saudek, R. Margreiter, H. Arbogast, L. 

Fernandez-Cruz, P. Pisarski, R. Viebahn, P. Peeters, R. Nakache, T. Berney, Y. 

Vanrenterghem, W. Bechstein, EuroSPK Study Group 2 

1 

Universite Catholique de Louvain Medical School, Department of Surgery and 

Abdominal Transplantation, Brussels Belgium 

2 

EuroSPK Central Office, Brussels, Belgium 

Switch to Rapamune (RAPA) and Switch Back to Calcineurin Inhibitors (CNI) 

in Kidney Transplantation: What Is The Cost 

Mark Reza Laftavi 1 , Ahmad Kandeel 1 , Melissa Denik 1 , Ramesh Kohli 2 , 

Mohammad Ibrahim 1 , Oleh Pankewycz 1 

1 

University at Buffalo and Kaleida Health, Transplantation Surgery, Buffalo, New York 

2 

University at Buffalo and Kaleida Health, Department of Medicine, Buffalo, New York 

Pharmacokinetics of Tacrolimus in Living Donor Liver Transplant (LDLT) and 

Deceased Donor Liver Transplant (DDLT) Recipients 

Ashok Jain MD 1 , 2 , Raman Venkataramanan PhD. 2 Tai Kwong PhD. 3 ,Ravi 

Mohanka MD 1 , Mark Orloff MD 1 , Peter Abt MD 1 , Randeep Kashyap MD 1 , 

Georgios Tsoulfas, MD 1 , Rajeev Saharma MD 1 , Cindy Mack RN 1 , Pam Batzold 

RN 1 , Adel Bozorgzadeh MD 1 

1 

Department of Surgery, Division of Transplantation: University of Rochester 

Medical Center, Rochester, NY. 

2 

School of Pharmacy University of Pittsburgh 

3 

Department of Biochemistry University of Rochester Medical Center, Rochester, NY 

Desensitization of Hepatitis C Viremic Patients Awaiting Live-Donor Renal 

Transplantation 

John Philip Leone 1 , W LeFlor 2 

1 

LifeLink HealthCare Institute, Tampa General Hospital, Tampa, FL 

2 

LifeLink Immunology Laboratory, Tampa, FL

FRIDAY, OCTOBER 19 

7:00 Continental Breakfast and Exhibits 

Mark Rosenberg, Moderator 

8:00 Indications for Changing Maintenance Immunosuppressive Therapy 

Robert Gaston (Birmingham, Alabama) 

Can We Individualize Immunosuppression 

8:30 Genomics 

William Oetting (Minneapolis, Minnesota) 

8:50 Proteomics 

David Rush (Winnipeg, Manitoba) 

9:10 Microarray 

Allan Kirk (Bethesda, Maryland) 

9:30 Cylex/Elispot 

Donald Hricik (Cleveland, Ohio) 


Oetting, Rush, Kirk, Hricik 


Bert Kasiske, Moderator 

10:30 Belatacept 

Flavio Vincenti (San Francisco, California) 

10:50 Do De Novo Calcineurin-Free Protocols Only Work in Cleveland 

Stuart Flechner (Cleveland, Ohio) 

11:10 Steroid and Calcineurin Sparing 

Darla Granger (Detroit, Michigan) 

11:30 How I Do It (Session V) Renal Dysfunction and a Biopsy with IF/TA 

Ronald Ferguson (Columbus, Ohio) 

Daniel Frey (Lafayette, Louisiana) 

Carl Cardella (Toronto, Ontario) 

Suphamai “Mike” Bunnapradist (Los Angeles, California) 

12:15 Lunch 

Connie Manske, Moderator 

1:00 Beyond Lip Service 

How (Should) I Do It: (Session VI) Reducing Long-term Mortality 

Bertram Kasiske (Minneapolis, Minnesota) 

Donald Hricik (Cleveland, Ohio) 

Edward Cole (Toronto, Ontario) 

Bruce Kaplan (Chicago, Illinois) 

2:00 Posttransplant Skin Cancer 

Maria Hordinsky (Minneapolis, Minnesota) 

2:25 BK Infection 

Ronald Shapiro (Pittsburgh, Pennsylvania) 


John Lake, Moderator 

3:15 What’s New in Liver Transplant Immunosuppression 

Abhi Humar (Minneapolis, Minnesota) 

3:40 What’s New in Pancreas Transplant: A Review of the International Conference 

David Sutherland (Minneapolis, Minnesota) 

4:05 ESRD in Recipients of Extrarenal Transplants 

Marshall Hertz (Minneapolis, Minnesota)



Moderator: Marci Knaak (Minneapolis, Minnesota) 

5:30 Adjourn 

Can You Top This Selected Case Studies 

Obesity 

Eugenia Steffens (Minneapolis, Minnesota) 

BK Infection 

Norma Sherwood (Rochester, Minnesota) 

Oxygen Requirement in Pretransplant Patients 

Marilyn Leister (Minneapolis, Minnesota) 

Antibody Lowering Protocol: Twice in One Patient 

Marci Siers (Minneapolis Minnesota) 

SATURDAY, OCTOBER 20 

7:00 Continental Breakfast 

Arthur Matas, Moderator 

8:30 Special Issues in Infants and Children (≤ 5) 

Blanche Chavers (Minneapolis, Minnesota) 

9:00 Special Issues in Children and Adolescents (> 5) 

Thomas Nevins (Minneapolis, Minnesota) 

9:30 Randomized Trials of Rapid Discontinuation of Prednisone 

Steve Woodle (Cincinnati, Ohio) 

9:55 Prednisone-free for Subgroups 

(African Americans, Children, Immunologic Diseases, Sensitized Recipients) 

Hassan Ibrahim (Minneapolis, Minnesota) 

10:20 Break 

Abhi Humar, Moderator 

10:40 Prednisone-free for Pancreas and SKP Recipients 

Dixon B. Kaufman (Chicago, Illinois) 

11:05 Contraindications to Prednisone-free Immunosuppression 

Edward Cole (Toronto, Ontario) 

11:30 Should Steroids be Restarted after Treatment for AR 

Abhi Humar (Minneapolis, Minnesota) 

11:50 The Pittsburgh Experience 

Ronald Shapiro (Pittsburgh, Pennsylvania) 


Woodle, Ibrahim, Kaufman, Cole, Humar, Shapiro 

12:30 Adjourn

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