JAFES-Booklet (English - pdf - 1103 Kb) - MEMS

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Trimester-specific Reference Range For Thyroid Function Among Pregnant Women Attending UMMC, Malaysia SC Lim, SP Chan, R Raduan, N Sabir, S Zawiah, YY Chew, M Thevarajah. University of Malaya Medical Centre, Kuala Lumpur Introduction: Thyroid disease is common in women of reproductive age. The necessity to detect and manage thyroidal illness in pregnancy is becoming increasingly important. Overt or even subclinical hypothyroidism has been shown in many instances to result in adverse maternal and fetal outcomes. In order to detect thyroid abnormalities during pregnancy, defining trimesterspecific reference intervals is necessary. Methods: This is a cross-sectional study carried out in the antenatal clinic and ward of University of Malaya Medical Centre from July to December 2007. 631 consecutive pregnant women with no known thyroid disorders were recruited. The ABBOTT AxSym system using microparticle enzyme immunoassays were utilized for analysis of TPOAb, TSH, fT4 and TT4. Subjects who were TPOAb positive or with moderate to large goiters were excluded from the analysis. 5th and 95th percentile values were used to determine the reference ranges. Results: A total of 537 subjects (1st trimester: 2nd trimester: 3rd trimester N=90:204:243) were available for analysis. Trimester-specific reference range for TSH, fT4 and TT4 were as follows: TSH FT4 TT4 1 st trimester 0.06 - 3.19 9.35 - 27.82 95.28 - 215.4 2 nd trimester 0.28 - 3.45 6.69 - 12.79 103.0 - 184.6 3 rd trimester 0.56 - 3.56 6.46 - 10.72 100.1 - 175.8 Conclusion: The main limitation of this study was we did not exclude patients with hyperemesis gravidarum resulting in a possible skewed data for thyroid hormone level in the 1st trimester. Nevertheless, we have established the trimester-specific reference intervals for TSH, fT4 and TT4 for second and third trimesters among the antenatal pregnant population in UMMC. 21
CASE REPORTS 22
Page 1 and 2: Vol 24, No 1 (SUPPLEMENT) ISSN 0857
Page 3 and 4: CLINICAL TRIALS AND STUDIES
Page 5 and 6: A Randomized Control Trial To Asses
Page 7 and 8: Abnormal Glucose Tolerance In Tanju
Page 9 and 10: Binge Eating Behavior And The Prefe
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Page 13 and 14: Growth Hormone Deficiency And Cogni
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Page 17 and 18: Prevalence Of Glucose Intolerance I
Page 19 and 20: Role of Adrenal Venous Sampling in
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Page 23: Treatment Outcome And Complications
Page 27 and 28: A Case Of Persistent Parathyroid Ca
Page 29 and 30: Bilateral Adrenal Hyperplasia In Mu
Page 31 and 32: Carney Complex: Cardiac Myxoma And
Page 33 and 34: McCune-Albright Syndrome Dr. Suhaim
Page 35 and 36: The Case Of A Troubled Patient, Tro
Page 37: TSH- Secreting Pituitary Macroadeno

JAFES-Booklet (English - pdf - 1103 Kb) - MEMS

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