JAFES-Booklet (English - pdf - 1103 Kb) - MEMS
JAFES-Booklet (English - pdf - 1103 Kb) - MEMS
JAFES-Booklet (English - pdf - 1103 Kb) - MEMS
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A Genome Scan for Malay<br />
Type 2 Diabetes Mellitus Patients<br />
Norhashimah AS a , Wan Nazaimoon WM a , Aziz Al-Safi b , Norlaila Mustafa c , Amir S Khir d , Zanariah Hussein e , Wan Mohamad WB b<br />
a Institute For Medical Research, b Hospital Universiti Sains Malaysia,<br />
c Hospital Universiti Kebangsaan Malaysia, d Penang Medical College, eHospital Putrajaya,<br />
Genetics have been implicated to affect susceptibility to diabetic nephropathy. Genomewide<br />
association study was carried out to elucidate and identify possible genetic markers<br />
for diabetes nephropathy in Malay Type 2 Diabetes Mellitus patients. DNA samples from<br />
84 subjects with normoalbuminuria, 51 subjects with microalbuminuria, 34 subjects with<br />
macroalbuminuria and 27 subjects with ESRD were genotyped on the Affymetrix 100K<br />
Single Nucleotide Polymorphism (SNP) array. Using Partek Genomic Suite to analyse the<br />
data, our results suggested that deletions on chromosome 6 starting position 19064 KBps<br />
to 73265 KBps and amplifications on chromosome 8 (5501 KBps to 137.1 MBps) were<br />
associated with different stages of albuminuria; most significance being in ESRD. In addition,<br />
there were significant amplifications and deletions (11719 KBps to 124.8 MBps and<br />
132 KBps to 65694 KBps respectively) on chromosome 12 in with macroalbuminuria and<br />
ESRD. The significance of these findings will be discussed.<br />
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