JAFES-Booklet (English - pdf - 1103 Kb) - MEMS

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A1c As A Screening Tool To Diagnose Diabetes Mellitus In A Rural Population-based Study Norlaila M, Nor Azmi K on behalf of the Malaysian Metabolic Syndrome Study (MSSM- UKM)* Objective: The objective of this analysis was to evaluate the clinical relevance of a single measurement of HbA1c as a screening tool for diabetes based on data derived from a small population based study. Methods: This was a cross sectional study of a rural population of five villages in Tanjung Karang. The survey was conducted from April to August 2008, involving Malaysians aged 18 and above. All subjects were randomly selected from households identified prior to the start of the study and gave their consent. Of the 543 subjects who were recruited, 382 non-diabetic subjects (70.3%) performed the 75 gram OGTT and 381 (99.7%) data were available for analysis. The sensitivity and specificity of the various levels of A1c (range from 5 till 6%) were determined against the results of the OGTT (gold standard) levels. Those with both sensitivity and specificity approaching 80% were deemed to have clinical potential as a cut-off point in the screening process. Results: Based on the OGTT, 22.8% (n=87) were diagnosed with type 2 diabetes. Subjects with diabetes had higher A1c levels than subjects without diabetes (6.8 ± 2.4% vs 5.3 ± 0.4%, p
Abnormal Glucose Tolerance In Tanjung Karang: The Burden Of Increasing Prevalence And Under-diagnosis Norlaila M, Nor Azmi K on behalf of the Malaysian Metabolic Syndrome Study (MSSM-UKM)* Objective: The aim of the study was to examine the prevalence of abnormal glucose tolerance among rural adult Malay population in Tanjung Karang following a standard 75 gram oral glucose tolerance test (OGTT). Methods: This was a cross sectional study of a rural population of five villages in Tanjung Karang. The survey was conducted from April till August of 2008, among Malaysians aged 18 and above. The subjects were randomly selected from households which were identified with the aid of the kirsh tables and the topographical charts of the district. Written consents were obtained prior to the face to face interviews using structured questionnaires, followed by laboratory tests. Of the 543 subjects who were screened, 435 subjects (80.1%) answered the questionnaires and 382 with no known history of diabetes mellitus (T2DM) (87.8%) completed the OGTT. Results: The prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and newly diagnosed T2DM following OGTT was 30.1%, 23.3% and 22.8% respectively. Taking into account those with known T2DM, 32.2% of the population has T2DM. Although OGTT yielded an additional 20.0% to the T2DM prevalence, still the majority of subjects with diabetes (62.1%) remained undiagnosed. This together with the fact that more than two-thirds of the population has an abnormal glucose tolerance (an independent risk factor for cardiovascular diseases) poses an enormous health burden to the population whose mean household income is far below that of national average (45.0% of subjects reported a monthly household income of RM500 or less). Conclusion: The health burden of abnormal glucose tolerance in Tanjung Karang is confounded by two main issues; that of increasing prevalence as well as under diagnosis of T2DM. * Norlaila M, Norasyikin AW, Suehazlyn Z, Wong Ming, Shahrul Azmin M, Noor Sharazat H, Wan Rosmaiza W, Shamita S, Norhaliza A, Nor Shaffinaz YA, Rabizah M, Kamarulzaman H, Nurul Hani M, Fadlin M, Amiliyaton K, Alawiyah O, Azhar I, Nor Azmi K. 4
Page 1 and 2: Vol 24, No 1 (SUPPLEMENT) ISSN 0857
Page 3 and 4: CLINICAL TRIALS AND STUDIES
Page 5: A Randomized Control Trial To Asses
Page 9 and 10: Binge Eating Behavior And The Prefe
Page 11 and 12: Gene Expression Profiling Associate
Page 13 and 14: Growth Hormone Deficiency And Cogni
Page 15 and 16: Prolonged QTc Interval Is Not Uncom
Page 17 and 18: Prevalence Of Glucose Intolerance I
Page 19 and 20: Role of Adrenal Venous Sampling in
Page 21 and 22: The Prevalence Of Metabolic Syndrom
Page 23 and 24: Treatment Outcome And Complications
Page 25 and 26: CASE REPORTS 22
Page 27 and 28: A Case Of Persistent Parathyroid Ca
Page 29 and 30: Bilateral Adrenal Hyperplasia In Mu
Page 31 and 32: Carney Complex: Cardiac Myxoma And
Page 33 and 34: McCune-Albright Syndrome Dr. Suhaim
Page 35 and 36: The Case Of A Troubled Patient, Tro
Page 37: TSH- Secreting Pituitary Macroadeno

JAFES-Booklet (English - pdf - 1103 Kb) - MEMS

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