Acute lung injury (ALI) and Acute respiratory distress syndrome ...
Acute lung injury (ALI) and Acute respiratory distress syndrome ...
Acute lung injury (ALI) and Acute respiratory distress syndrome ...
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Mechanisms of ventilation induced<br />
<strong>lung</strong> <strong>injury</strong><br />
• Healthy animals developed <strong>lung</strong> <strong>injury</strong> if ventilated<br />
with PIP > 40 cm H 2 O “Barotrauma”<br />
– Kolobow Am Rev Resp Dis 135:312, 1987<br />
• Identical pressures did not cause <strong>injury</strong> if <strong>lung</strong><br />
expansion was restricted “Volutrauma”<br />
– Hern<strong>and</strong>ez J Appl Physiol 1989 66:2364<br />
• PEEP attenuated the <strong>injury</strong> of high pressure<br />
ventilation “Repetitive opening <strong>injury</strong>”<br />
– Webb Am Rev Resp Dis 1974; 110: 556
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