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Acute lung injury (ALI) and Acute respiratory distress syndrome ...

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Vt (ml/kg)<br />

9<br />

8<br />

7<br />

6<br />

Physiology of higher / lower PEEP<br />

Tidal volume<br />

Low PEEP<br />

High PEEP<br />

Pplat (mm Hg)<br />

28<br />

27<br />

26<br />

25<br />

24<br />

Pplat<br />

5<br />

16<br />

0 1 2 3 4 7<br />

PEEP<br />

23<br />

0.65<br />

0 1 2 3 4 7<br />

FIO2<br />

Low PEEP<br />

PEEP<br />

14<br />

12<br />

10<br />

FIO2<br />

0.60<br />

0.55<br />

0.50<br />

0.45<br />

High PEEP<br />

8<br />

0.40<br />

6<br />

0 1 2 3 4 7<br />

0 1 2 3 4 7<br />

Study day<br />

0.35<br />

N Engl J Med 2004; 351:327<br />

Study day

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