Acute lung injury (ALI) and Acute respiratory distress syndrome ...
Acute lung injury (ALI) and Acute respiratory distress syndrome ...
Acute lung injury (ALI) and Acute respiratory distress syndrome ...
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RCT of Steroids for persistent ARDS<br />
• ARDS x 7 d with LIS > 2.5<br />
• R<strong>and</strong>omized (2:1) to<br />
steroids vs. placebo<br />
– MPS 2 mg/kg load then<br />
– 2 mg/kg/d x 14 d then<br />
– 1 mg/kg/d x 7 d then<br />
– 0.5 mg/kg/d x 7 d etc to 32 d<br />
• Improvement = LIS by 1<br />
• If no improvement at 10d,<br />
crossed over<br />
Placebo 8<br />
2 died<br />
2 improved<br />
4 cross-overs<br />
24 r<strong>and</strong>omized<br />
MPS 16<br />
16<br />
Meduri U. JAMA 1998; 280:159
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