Vascular intervention

Historic Highlights 

of 

Interventional 

Radiology

INTERVENTION RADIOLOGY 

Vascular intervention 

Nonvascular intervention 

- important to establish a good 

radiologist/patient relationship 

and to obtain informed consent

Father of 

IR 

PTA

Cardiac 

catheterization 

and angiographic 

techniques 

of 

future

“A A cardiac catheter can be more than a 

tool for passive means for diagnostic 

observation; used with imagination it 

can become an important surgical 

instrument”. 

June 1963

Catheters should 

replace scalpels

June 1963

5oth year anniversary of Congressus 

Radiologicus Cechoslovacus 

1963-2013 

Planting the seeds of Interventional Radiology 

by Charles T Dotter

INTERVENTION RADIOLOGY 

The procedure should be undertaken only 

if there is a clear clinical indication 

Any procedure should d be in the best 

interest of the patient 

The potential benefits of the procedure 

should d outweigh the risk

Analgesia and Sedatio 

Interventional techniques require patient 

co-operation. 

operation. 

The patient must be comfortable and pain 

free. 

The vast majority of work involves – sedation 

and analgesic techniques.

Interventional Suit Design

Following the procedure the patients 

recovery suite 

day ward

1953 I Seldiger: : Percutaneous 

catheterization 

1964 C Dotter: SFA recanalization 

(coaxial catheters) 

1974 A Grüntzig: Balloon catheter PTA

PTA 

- percutaneous transluminal angioplasty 

PTA increases the luminal diameter of a 

stenotic artery by causing plaque fracture, 

often with accompanying local intima- 

medial dissection.

January 16, 1964

Catheter therapy 

“Transluminal angioplasty” 

was born 

January 16, 1964

Balloon Angioplasty 

1975 

A. Grüntzig

PTA Mechanism 

Vessel wall permanent „overstretching“ 

Plaque remodelation/compression 

Intima/medie controlable 

dissection/rupture

PTA 

Indications (extremity PTA) 

1. Lifestyle-limiting limiting claudication. 

2. Critical ischemia (rest pain, ulcer, gangrene). 

3. To increase inflow or outflow prior to or after 

bypass surgery. 

4. Bypass graft stenosis. 

The balloon diameter should be equal to the adjacent 

normal vessel diameter.

PTA 

Contraindications (extremity PTA) 

Absolute 

1. Patient is medically unstable. 

2. Stenosis is not hemodynamically significant. 

3. Stenosis is immediately adjacent to an 

aneurysm. 

4. Ulcerative disease with evidence of distal 

embolization is present.

Team cooperation 

angiologist 

vascular surgeon 

interventional radiologist

STENTS 

•balloon-expandable 

•self-expandableexpandable 

Aim of stent implantation is to keep 

arterial lumen widely open with smooth 

surface. It prevents „recoil“,, but it does 

not prevent intimal hyperplasia or 

atherosclerosis progression.

Stent Design 

Stents (a form of scaffolding used to contain and reinforce the 

patency of a biological conduit) 

 

 

– plastic (hepatobiliary, urinary 

system) 

– metal (stainless steel, nitinol) 

balloon expandable 

self-expanding 

expanding 

(problems – thrombosis, intimal hyperplasia)

alloon-expandable 

stents

Balloon Expandable Stent 

1985 

J. Palmaz

Expandable Nitinol Coil Stent 

1983 

C. Dotter

Self-Expanding Medinvent Stent 

1985 

H. Wallsten 

Wallstent

Categories of catheter- 

based tools 

Access needles 

18-gauge 

21-gauge micro-puncture kit 

Sheats-4 4 Fr and greater 

Short straight (10-12 12 cm and 22-25 25 cm lengths) 

Long straight (90cm) 

Preshaped crossover sheaths (45-60)


based tools 

Wires-0.014 to 0.035 inches diameter (regular and exchange- 

lenght) 

Hydrophilic (e.g.glide wire) 

Nonhydrophilic (i.e., working wires) 

Starter (e.g., starter J-wire J 

or Bentson wire) 

Stiff (e.g., Amplatz, Cook, Inc., Bloomington, IN) 

Catheters 

Nonselective flush (e.g., straight, pigtail, Omni) 

Selective/end hole (e.g., angled glide, Bernstein, Cobra, 

Simmons) 

Infusion (e.g., multiside hole thrombolytic) 

Guide Catheters


based tools 

Balloons 

Compliant 

Noncompliant 

Cutting 

Cryo-balloons 

Stents 

Balloon-expandable 

Self-expanding 

expanding 

Coreved (i.e., stent grafts) 

Intravascular ultrasound (IVUS) 

Mechanical thrombolysis (e.g., Angiojet, Possis Medical, Minneapolis, MN 

Access or puncture site closure devices 

e.g., Angiojet, Possis Medical, Minneapolis, MN)

Levels of clinical evidence and 

Levels 

classification of 

recommendations 

Level A Evidence from multiple randomized trials or meta-analyses 

analyses 

Level B Evidence from single randomized trial or nonrandomized 

studies 

Level C Evidence from retrospective or case studies or case studies or 

from expert opinion

Levels of clinical evidence and 

Classification 

classification of 

recommendations 

Class I Treatment or procedur eis useful or effective (i.e., benefit far 

outweighas the risk and treatment should be performed) 

Class IIa 

Recommendation in favor or treatment or procedure 

being useful or effective (i.e., benefit outweighs the risk and it is 

reasonable to perform treatment) 

Class IIb 

Usefulness or effectiveness leas well established (i.e., 

benefit is equal to or greater than the risk and the procedure or o 

treatment may be considered) 

Class III 

Treatment or procedur eis not useful and may be 

harmful (i.e., risk outweighs the benefits and treatment should not 

be performed)

Categories of chronic limb 

ischemia 

Grade Category Clinical description Objective criteria 

0 0 Asymptomatic-no 

significant occlusive 

disease 

Normal treadmill/stress test 

1 Mild claudication Complete treadmill test; AP 

after test >50 mm Hg 

I 2 Moderate claudication Between categories 1 and 3 

3 Severe claudication Cannot complete treadmill 

test; AP after test

Categories of chronic limb 

ischemia 

Grade Category Clinical description Objective criteria 

II 4 Ischemia rest pain Resting AP

11,3 mm 

10,7 mm

ILIAC ARTERIES 

Indications: stenoses < 10 cm, 

occlusions < 5 cm 

Technical success rate > 95 % 

Primary patency rate (4 years FU) > 

75 % 

Complications < 5 % 

Routine procedure, thousands of patients followed 

up.

ILIAC ARTERIES 

PTA vs Surgery 

↓long-term patency ↑complications 

(mortality 2-72 

7 %) 

↓hospital stay ↑recovery 

price

Stent EXPRESS 

Vascular LD 

9 mm x 37 mm 

Stent EXPRESS 

Vascular LD 

8 mm x 37 mm

FEMOROPOPLITEAL ARTERIES 

Indications: stenoses/occlusions < 5- 

10cm 

Technical success rate > 90 % 

Primary patency (4years FU) 45-50 50 % 

Complications 5-85 

8 % 

Negative preventing factors: lesions over 10 cm, 

calcifications, artery diameter < 5 mm, poor run- 

off. 

Routine procedure, thousands of patients followed- 

up.

FEMOROPOPLITEAL 

ARTERIES 




price


ARTERIES 




price

INFRAPOPLITEAL ARTERIES 

PTA not generally accepted as a 

method of first choice 

Technical success rate > 90 % in 

selected patients 

Two-years limb salvage 70 % (! 

Does not correspond to the 

patency rate!) 

Publications: tens to hundreds of patients

INFRAPOPLITEAL 

ARTERIES 


No data available. PTA sometimes 

performed in patients who are not suitable 

candidates for surgery, or one method may 

support the other. Expensive, but 

potentially limb salvaging procedure.

PTA OF LOWER LIMBS ARTERIES 

Accepted method of arterial occlusive 

disease treatment. 

It should be performed by well 

trained specialists in dedicated cath- 

labs. 

It should not compete with vascular 

surgery, but should be it‘s s partner.

COMBINATION OF 


BYPASS AND 

INFRAPOPLITEAL PTA IN 

PATIENTS WITH 

CRITICAL LOWER LIMB 

ISCHEMIA

Infrapopliteal PTA 

Take home points 

Long and expensive procedure 

If successful, it can help to jeopardised 

limb salvage 

In some cases even partial 

revascularization can remove the 

symptoms 

Long-term patency unknown 

Long-term limb salvage 50 – 70 %

IKEM clinical c 

follow ow up 

No.of limbs followed 

L.salvage(secondary) 

1 year 469 380 81 % 

2 years 300 237 79 % 

3 years 184 140 76 % 

4 years 123 91 74 % 

5 years 78 55 71 %

Subintimal recanalization 

• Long occlusion 

(>10 cm) 

• Reentry 90 %. 

(A. Bolia, 1990 )

Case – SIR AFS + a. fibularis, ipsilateral access 

• 76-y.o, 7 years after FP BP, rest pain

5 mm 6 mm

CTA za 12 měsíců

CTA za 12 měsíců

CTA after 1 y

OUTBACK® LTD 

Re-Entry Catheter 

Cordis - 6, 5 F

PTRA 

Aim: to open stenotic/ occluded renal artery 

without causing any harm to the 

kidney perfusion and function. 

The effect of PTRA should be permanent.

PTRA: Approach 

Femoral artery most frequently used. 

Ipsilateral femoral artery preferred.

STENT IMPLANTATION 

● PTRA complication/failure 

● Occluded RA recanalization 

● Ostial RA stenosis 

● Asymmetric/ ulcerated stenosis 

● Solitary kidney

Stentgraft

Stentgraft 

A/V shunt pseudoaneurysm aneurysm

Aortic Stentgraft Follow-up

Type B aortic dissection

Enlargement of landing zones 

Hybrid repair: extended the limits of EVAR 

extra-anatomic rerouting or debranching procedure

Stentgraft

Stentgraft

Stentgraft

Catheter-directed 

thrombolysis 

A catheter is inserted and used to deliver 

the lytic agent directly into the thrombus, 

thus greatly improving the efficiency of 

clot lysis and provides access for 

adjunctive techniques such as angioplasty 

and stent placement.


thrombolysis

Peripheral Arterial Interventions 

= thrombolysis as the only option of 

primary treatment 

– pacients s with complete outflow tract 

occlusion 

– pacients with acute myocardial 

infarction

Acute critical ischemia 

 

percutaneous aspiration embolectomy


local thrombolytic 

therapy 

(accelerated form)

Pulse-spray pharmacomechanical 

thrombolysis 

22 mg rt-PA


thrombolysis as the only option of primary treatment 

– pacient 

with complete outflow tract occlusion

Pulse-spray pharmacomechanical 

thrombolysis

20 mg rt-PA


thrombolysis + PTA

20 mg rt-PA

veckebauer4bo 

veckebauer4co


thrombolysis + surgery

48 mg rt-PA

TREATMENT OF VENOUS 

THROMBOSIS

Deep vein thrombosis 

= DVT 

DVT is serious and potentially life 

threatening disease, often resulting 

in complications such as pulmonary 

embolism, phlegmasia cerulea dolens, 

and post-thrombotic syndrome.

DVT 

Risk factors: 

1. Surgery, esp. on legs / pelvis (orthopedic) 

2. Severe trauma 

3. Prolonged immobilization 

4. Malignancy 

5. Obesity 

6. Diabetes 

7. Pregnancy and for 8 – 12 weeks postpartum

DVT 

Risk factors: 

8. Oral contraceptives 

9. Decreased cardiac function 

10. Age > 40 years 

11. Varicose veins 

12. Previous DVT 

13. Patients with blood group A > blood group O 

14. Polycythemia 

15. Smoking

DVT 

Localization: 

1. Dorsal calf veins 

(± ascending thrombosis) 

2. Iliofemoral veins 

(± descending thrombosis) 

3. Peripheral + iliofemoral veins simultaneously

Diagnosis of suspected (symptomatic) 

acute DVT 

• Local symptoms due to obstruction 

(warmth, swelling, blanching of skin / blue leg, pain) 

• Duplex US or IPG 

• Venography or MRV (CTV)

Venous interventions 

Acute 

OCCLUSION 

Chronic

Therapy of DVT 

• Standard heparin therapy 

• Systemic thrombolysis 

• Surgical thrombectomy 

• Catheter-directed thrombolysis 

• Percutaneous mechanical thrombectomy 

• Combination of more techniques

Heparin therapy 

Only 10% of patients have spontaneous 

lysis of their DVT within 10 days of 

heparin therapy, and up to 40% of patients 

continue to have propagation of thrombus 

despite treatment with heparin. 

(Sherry S. Semin Intervent Radiol 4:331-337, 1985) 

(Krupski WC, et al. J Vasc Surg 12:467-475, 1990)

Thrombolytic therapy 

The resulting benefits would be expected to include: 

1) improved if not normalized venous circulatory 

hemodynamics, 

2) decreased circulatory burden on the superficial 

venous system with reduced varix formation, 

3) decreased collateral formation, 

4) reduced damage to the venous valves. 

(Savader SJ: Peripheral and central deep venous thrombosis. In Savader S, Trerotola SO 

(eds): Venous interventional radiology with clinical perspectives. New York,Thieme 

Medical Publishers, 1996)

DVT 

Indication 

1) Symptomatic iliofemoral thrombosis 

(≤ 10 days) 

2) Phlegmasia cerulea dolens

Catheter-directed thrombolysis for 

lower extremity DVT: Report of a 

national multicenter registry 

Mewissen MW, Seabrook GR, Meissner MH, et al. Radiology 211:39-49, 1999. 

The Venous Registry described treatment of 303 limbs in 287 

patients with acute and chronic lower extremity DVT treated with 

urokinase (mean, 7.8 million U and 53.4 hours), the overall complete 

and partial lysis rate was 83% with a 1-year patency rate of 60%. 

Patients with complete lysis had higher 1-year patency rate (79%). 

Iliofemoral thromboses fared significantly better than 

femoropopliteal thromboses (no iliac involvement) with 1-year 

patency rates of 79% and 64%, respectively.

Catheter-directed thrombolysis for 

lower extremity DVT: Report of a 

national multicenter registry 

Mewissen MW, Seabrook GR, Meissner MH, et al. Radiology 211:39-49, 1999. 

Complications 

Major bleeding ……………………….. 54 (11%) pts 

Pulmonary embolism ……………….. 6 (1%) pts 

Deaths …………………………………. 2 (


thrombolysis 

A catheter is inserted and used to deliver 

the lytic agent directly into the thrombus, 

thus greatly improving the efficiency of 

clot lysis and provides venous access for 

adjunctive techniques such as angioplasty 

and stent placement.

Recommendations for catheterdirect 

infusion rt-PA (Alteplase) 

(Actilyse; Boehringer Ingelheim Pharma KG, SRN) 

1) 0.5 →1.0 mg/h (0.12 → 2.0 mg/h) 

2) Total dose should not exceed 20 - 40 mg 

3) Delivery (pulsed spray vs. drip infusion) not crucial 

4) Concomitant heparin: 500 IU/h; PTT: 1.25 - 1.5 times 

control 

(Mazer MJ. Thrombolysis: Venous. Eds. Workshop Handout Book. Fairfax, VA: 

SCVIR, 2001; 585-606)

Inferior vena cava filters 

1. Free floating iliofemoral or IVC 

thrombus 

2. Recurrent PE despite adequate 

anticoagulation 

3. Mechanical thrombectomy

Catheter-directed thrombolysis 

Approach 

• Ipsilateral popliteal vein 

(posterior tibial vein, dual crossed popliteal vein 

access) 

• Internal jugular vein 

• Contralateral femoral vein

Case 

• 25 y.o. female 

• 11 days history of right l. limb edema 

• Oral contraceptives

43 mg rt-PA

Pulsed - spray technique 

(rt-PA) 

• 0.5 ml pulsed every 90 seconds 

• 0.5 ml pulsed every 3 minutes 

• 0.5 ml pulsed every 6 minutes 

= 2.0 mg/h 

= 1.0 mg/h 

= 0.5 mg/h 

(Mazer MJ. Thrombolysis: Venous. Eds. Workshop Handout Book. 

Fairfax, VA: SCVIR, 2001; 585-606) 

• pulse spray injector can be used

56 mg rt-PA

MRV follow-up 12 months

Following therapy 

• LMWH 

• Warfarin (INR 2 – 3, for 6 months) 

• Venous compression stocking

Percutaneous mechanical 

thrombectomy/ thrombolysis 

(PMT) 

Advantages 

1. Immediate clot removal with restoration 

of improved circulatory hemodynamics 

2. Rapid resolution of venous thrombosis in 

minutes 

3. Reduced expense versus thrombolytic or 

surgical thrombectomy 

4. Decreased room time versus thrombolytic 

therapy without the need for multiple 

follow-up venograms

Mechanical devices

Rotarex - fragmentation

Case 


• Acute (7 days) history of left l. limb edema 

• Oral contraceptives

Cavography 

Left iliofemoral 

thrombosis 

24 mm 

IVC calibration

Filter insertion 

9 mm PTD 

(2 passes)

Procedure pics

15 mm PTD 

(5 passes) 

After PTD + aspiration

Residual 

clots in 

filter

Residual clots in filter

Result after stents placement 

Smart stents 

(14 x 60 mm) 

(14 x 40 mm)

Final result after 5 mg rt-PA (bolus) 

application

Dialysis graft occlusion

Case 

- 2 days thrombosis VCI 

- intranetal trauma

3,8 mg rt-PA

4 mm x 6 cm

Chronic occlusion

Case 


• Leiden mutation, oral contraceptives, 

immobilization for knee distorsion, 

left iliofemoral thrombosis (1 year) 

• Left l. limb edema

Basic CEAP classification of 

chronic venous disease 

Clinical 

C 0 

no signs of venous disease 

C 1 

telangiectasias or reticular veins 

C 2 

varicose veins 

C 4 

pigmentation or eczema 

C 5 

healed venous ulcer 

C 6 

active venous ulcer 

Anatomy 

As superficial veins 

Ap perforator veins 

Ad deep veins 

Etiology 

Ec congenital 

Ep primary 

Ea secondary (post-trombotic) 

Pathopfysiology 

Pr reflux 

Po obstruction 

Pr,o reflux and obstruction

Balloon 5 mm 

Balloon 8 mm

Wallstent 14 x 60 mm 

Wallstent 12 x 90 mm

Chronic occlusion 


• left iliofemoral thrombosis (16 years) with 

PE 

• chronic l. limbs edema 

• varix and collateral formation

CTF

5 mm x 4, 6 cm

12 mm x 4 cm

Wallstent 14 mm x 6 cm

Wallstent 14 mm x 6 cm 

18 mm x 9 cm

Final result

ILIAC VEIN COMPRESSION 

SYNDROME 

= May-Thurner syndrome 

= Cockett´s syndrome 

Typ I 80 %

ILIAC VEIN COMPRESSION SYNDROME 

(Patel NH, et al. JVIR 2000; 11;1297-1302)

ILIAC VEIN COMPRESSION 

SYNDROME 

= May-Thurner syndrome, Cockett´s syndrome 

HISTORICAL BACKGROUND 

1851 Virchow, pelvic vein thrombosis occurs five times more 

frequently on the left side 

1957 May and Thurner, three types of ,,spurs“ (430 cadavers) 

1965 Cockett and Thomas, four variants of compression 

1991 Okrent, thrombolytic therapy and angioplasty for treating 

an acutely thrombosed left common iliac vein 

1994 Semba and Dake, catheter-directed thrombolysis and 

stents

Sinus stent 16 x 50 mm

Case 

Aplasia VCI 

lTL 1 mg rt-PA/h

20 mg rt-PA final result

CTF after 3 days

INFRAINGUINAL STENTS

Case 

Balloon 12 x 40 mm

Smart stent 14 x 60 mm

CONCLUSION 

Catheter-directed thrombolysis is effective 

and safe (lower dose of thrombolytic 

agent and heparin). 

Inferior vena cava filters are rarely 

necessary.

CONCLUSION 

Mechanical thrombectomy is a potential 

therapeutic option in patients with proximal DVT. 

PMT and catheter-directed thrombolysis reduce 

the required thrombolytic dose and infusion 

duration. 

Clinical experience with mechanical devices is 

quite limited at present, prospective randomized 

trials are necessary.

CONCLUSION 

Any hemodynamically significant residual 

occlusive disease in the IVC or iliac or 

proximal femoral venous segments should 

be treated with endovascular stent 

placement.

CONCLUSION 

The goal in the treatment of DVT is 

completing the procedure in a single day 

without to resort to a costly overnight 

admission to a Critical Care Unit, the best 

as an outpatient (LMWH).

Endovascular treatment 

of massive pulmonary embolism

Rationale for thrombus fragmentation 

Mechanical fragmentation and peripheral dispersion 

of clots is likely to reduce PAP and increase perfusion

Endovascular mechanical 

INDICATION 

fragmentation 

1) Patients with massive pulmonary embolism 

and with contraindication for thrombolysis 

2) Patients with massive pulmonary embolism 

after failure of thrombolysis

Pigtail Rotation Catheter 

Pigtail diameter 12 mm 

8 mm

PTD 

(Roček M, et al. Eur Radiol 1998; 8: 1683-1685)

Pulmonary artery stent 

placement 

žíle. 

(Koizumi J, et al. Cardiovasc Intervent Radiol 1998; 21:254-257)

TIPS – Transjugular intrahepatic 

porto-systemic shunt 

.

Experimental Transjugular 

Intrahepatic Portosystemic Shunt 

TIPS - 1969 

Rösch Hanafee Snow

Clinical TIPS 

1988 

G. Richter

TIPS 

IND 

- uncontrollable hematemesis secondary 

to liver disease 

- refractory ascites

TIPS

TIPS

TIPS + embolization

TIPS

TIPS

TIPS

Coils 

= many types and sizes are available. 

(Gianturco-Anderson-Wallace coils in the early1970´s) 

stainless steel coils 

platinum coils 

± wool, silk, Dacron 

permanent focal occlusion leaving 

the vessel distal to the coils patent

The ideal coil 

thrombogenic 

an easy, precise, rapid, safe, 

motion free deployment 

easy to see 

wide range of shapes and size 

no jamming 

easy reposition and remove 

an exchange-detachment system 

MRI compatible 

non-traumatic to the vessel 

cheap

non-detachable coils 

detachable coils 

Coils 

- electrically 

- hydrostatically 

- mechanically

Prior to performing 

an embolization 

the clinical situation must be reviewed. 

The endovascular approach can be helpful 

in patients with severe underlying 

coexistent morbidity and a high risk for 

surgery. 

The recovery time in patient treated 

endovasculary is substantially shorter.

Indications 

peripheral arterial and venous 

vasculature 

intracranial aneurysms 

neuro-vascular abnormalities 

(arterio-venous malformations, 

arterio-venous fistulae)

Matrix 2 360 o Detachable Coils 

Uniform Distribution, From Start to Finish 

•Four Softness Grades 

•Same Complex 360 Shape from Start-to-Finish 

Firm 360 Coils 

Standard 360 

SR Coils 

Soft 360 SR Coils 

UltraSoft 360 

SR Coils 

First Complex 

UltraSoft

Catheters 

Diagnostic catheters 

(4, 5 F, witout side holes) 

Coaxial systems (microcathetr) 

Balloon occlusion catheter

Peripheral Hydrocoil 

It is a platinum coil 

covered with an 

expandable hydrogel 

polymer offering 

unique mechanical 

occlusion. 

It is available in 2 

version pushable & 

detachable.

Peripheral Hydrocoil 

It is offering superior 

volume filling and 

packing density: 

• Up to 5 times more 

than conventional coils 

for 

the 0.018" system 

• Up to 4 times more 

volume filling than 

conventional coils for 

0.035" system 

Hydrocoils Platinum 

coils

Coiling complications 

dislodgement/migration 

malposition 

paradoxical embolization, insufficient 

embolization 

displacement from guiding catheter 

during deployment 

vessel damage 

jamming

OCCLUDERS 

Amplatzer septal occluder 

Amplatz vascular plugs 

other devices 

homemade occluders 

detachable balloons

Amplatzer vascular plugs 

- are designed to provide optimal 

embolization of peripheral veins and 

arteries through single device occlusion, 

full cross-sectional vessel coverage, 

controlled and precise deployment. 

AVP AVP II AVP III AVP IV

Amplatzer vascular plugs 

A single device frequently blocks a vessel 

that would have required many coils, 

which makes it a very efficient and costeffective 

alternative to coils or surgery. 

Plugs have the ability to recapture and 

reposition, if necessary.

65yo woman, 

she had 

hemodialysis 

cath before 

10 yrs. 

She had angina 

pectoris

efore 

after 

cause: hemodialysis cath placement 

imaging: CT 

treatment: Amplatzer plug 

result: excellent 

FU: CT

A-V V pulmonary malformation

A-V V pulmonary malformation 

after intervention

Vascular intervention

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